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Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

17 Jan 2017

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

A team of researchers from Australia and France have uncovered new insights into how to prolong the lifespan of the body's disease-fighting natural killer (NK) cells.

17 Jan 2017

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Standard chemotherapy is a blunt force instrument against cancer - and it's a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body.

17 Jan 2017

Talking therapy strengthens connections in the brains of people with psychosis, study shows

A new study from King's College London and South London and Maudsley NHS Foundation Trust has shown for the first time that cognitive behaviour therapy strengthens specific connections in the brains of people with psychosis, and that these stronger connections are associated with long-term reduction in symptoms and recovery eight years later.

17 Jan 2017

Analgesic effects of opioids can be mediated via immune cells

Opioids are the most powerful painkillers. Researchers at the Charité - Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells.

17 Jan 2017

Diminishing levels of GABA may play role in age-related cognitive decline

Diminishing levels of GABA, the primary inhibitory neurotransmitter in the brain, may play a role in cognitive decline as we age, according to a study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

17 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

Synthesized steroid prevents lethal protein buildup in animal model of Parkinson's disease

A synthesized steroid mirroring one naturally made by the dogfish shark prevents the buildup of a lethal protein implicated in some neurodegenerative diseases, reports an international research team studying an animal model of Parkinson's disease.

17 Jan 2017

Ludwig study uncovers ancient cellular response that underlies spread of aggressive skin cancer

Each day, more than 1,600 people die from cancer in the US, and 450 in the UK, mostly because the disease has spread beyond a stage when surgery is an effective cure and has become resistant to therapy. Despite decades of research, understanding why cancer cells become invasive has remained shrouded in mystery.

17 Jan 2017

Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

Investigators at the University of Utah have identified distinct differences in the hearts of advanced heart failure patients who have defied the odds and showed signs of recovery from the disease. Published online in the journal Circulation, the new findings could help clinicians identify the best candidates for cardiac recovery therapies.

17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Researchers find explanation for link between persistent infection and long-term immunity

Many infectious diseases are one and done; people get sick once and then they are protected from another bout of the same illness.

17 Jan 2017

Yale researchers discover how tick-borne bacteria cause infection

Before infecting humans, tick-borne bacteria or viruses first have to get past a tick's defenses to colonize it.

17 Jan 2017

Naturally-occurring compound can inhibit early formation of toxins linked to Parkinson's Disease

A naturally-occurring compound has been found to block a molecular process thought to underlie Parkinson's Disease, and to suppress its toxic products, scientists have reported.

17 Jan 2017

Knowledge bank approach could help find best treatment option for AML patients

An international collaboration led by clinical researchers at the Wellcome Trust Sanger Institute has shown proof-of-concept that truly personalised therapy will be possible in the future for people with cancer.

17 Jan 2017

Every meal triggers short-term inflammatory responses in healthy individuals

When we eat, we do not just take in nutrients - we also consume a significant quantity of bacteria. The body is faced with the challenge of simultaneously distributing the ingested glucose and fighting these bacteria.

17 Jan 2017

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

16 Jan 2017

Functional deficits caused by mini-strokes can last longer than previously thought

Evidence overwhelmingly supports a link between cognitive decline and cerebrovascular diseases such as atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Not only do individuals with cerebrovascular diseases have a much higher incidence of cortical microinfarcts (mini-strokes), but post-mortem histological and in vivo radiological studies also find that the burden of microinfarcts is significantly greater among people with vascular cognitive impairment and dementia (VCID) than in age-matched, non-demented individuals.

16 Jan 2017

Spectroscopy and computer help RUB scientists gain new insights into workings of protein switches

Using a combination of infrared spectroscopy and computer simulation, researchers at Ruhr-Universität Bochum have gained new insights into the workings of protein switches.

16 Jan 2017

Researchers discover underlying cause for formation of granulomas

Granulomas are tissue nodules of immune cells that occur in diseases such as tuberculosis and sarcoidosis and can damage many organs.

16 Jan 2017

Medical Science News

Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

Research offers new clues to prolong lifespan of the body's disease-fighting NK cells

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Talking therapy strengthens connections in the brains of people with psychosis, study shows

Analgesic effects of opioids can be mediated via immune cells

Diminishing levels of GABA may play role in age-related cognitive decline

Epigenetic changes drive successful metastases of pancreatic cancer cells

Synthesized steroid prevents lethal protein buildup in animal model of Parkinson's disease

Ludwig study uncovers ancient cellular response that underlies spread of aggressive skin cancer

Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Researchers find explanation for link between persistent infection and long-term immunity

Yale researchers discover how tick-borne bacteria cause infection

Naturally-occurring compound can inhibit early formation of toxins linked to Parkinson's Disease

Knowledge bank approach could help find best treatment option for AML patients

Every meal triggers short-term inflammatory responses in healthy individuals

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Functional deficits caused by mini-strokes can last longer than previously thought

Spectroscopy and computer help RUB scientists gain new insights into workings of protein switches

Researchers discover underlying cause for formation of granulomas

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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