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TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's blood vessels.

30 Apr 2025

Researchers identify blood biomarkers linked to Long COVID symptoms

Researchers at Karolinska Institutet have identified biomarkers in the blood associated with symptoms of long COVID, particularly severe respiratory disorders.

30 Apr 2025

Researchers tie childhood vitamin D shortfalls to adult heart disease

Low childhood levels of 25-hydroxyvitamin D were linked to a significantly higher risk of early adult-onset atherosclerotic cardiovascular disease (ASCVD). The association remained even after accounting for conventional childhood risk factors and persisted across multiple analyses.

30 Apr 2025

Study links impaired synaptic pruning to autism

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of behavior or interests.

30 Apr 2025

Clusterin identified as key marker for aging in blood stem cells

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological mechanisms of aging.

30 Apr 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

What’s missing in plant-based nutrition research? A new review explains

A new scoping review reveals major inconsistencies in how plant-based diet diversity is defined, measured, and linked to health outcomes in high-income countries. The findings highlight a critical need for standard definitions and validated assessment tools in future research.

30 Apr 2025

NR2F1 promotes cataract formation by activating STAT3 pathway

Cataracts are a prevalent ocular condition characterized by a progressive decline in vision, ultimately leading to blindness.

30 Apr 2025

Extreme temperatures drive people toward high-fat diets, study finds

Short-term exposure to extreme temperatures alters dietary patterns by increasing fat intake, even when total calorie consumption remains stable. This shift, driven by physiological appetite regulation, raises the risk of high-fat diets and diet-related diseases, especially among vulnerable groups.

30 Apr 2025

New protein target offers hope for treating high blood pressure and aortic aneurysms

Oxidative stress can occur when our cells are exposed to harmful molecules called "reactive oxygen species" over time. These reactive oxygen species can damage cells and are found in important disease states, such as high blood pressure and aortic aneurysms.

30 Apr 2025

Machine learning provide new insights into how the brain responds to heroin use

Object recognition software is used by law enforcement to help identify suspects, by self-driving cars to navigate roadways and by many consumers to unlock their cell phones or pay for their morning coffee.

30 Apr 2025

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Folic acid plays a dual role in breast cancer depending on dose and context. While moderate intake may reduce risk, high levels or genetic variants disrupting metabolism may promote tumor progression via altered DNA methylation.

30 Apr 2025

Single DNA mutation disrupts tumor suppressor pathways in blood cancer

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key tumor-suppressing pathways, opening up new avenues for blood cancer treatment.

30 Apr 2025

Mindfulness-based therapy found to decrease opioid cravings and improve emotional health

Researchers from the University of California San Diego have found that Mindfulness-Oriented Recovery Enhancement (MORE) can help rewire the brain's response to natural healthy pleasure, leading to improved mood, greater attention to positive experiences and reduced opioid cravings.

30 Apr 2025

Curcumin shows promise for treating obesity, inflammation, and neurodegenerative diseases

Researchers explore the medicinal role of curcumin in the treatment and prevention of neuroinflammation and metabolic disorders.

30 Apr 2025

New antiviral compounds show broad protection against COVID-19 variants

Novel Mpro inhibitors exhibit broad activity against SARS-CoV-2 and other coronaviruses.

30 Apr 2025

Brain damage linked to increased impulsivity and social influence

People who have damage to a specific part of their brains are more likely to be impulsive, and new research has found that damage also makes them more likely to be influenced by other people.

29 Apr 2025

Better sleep, BMI, and glucose control lower female infertility odds

A new study using NHANES data found that higher Life’s Crucial 9 (LC9) scores, reflecting better cardiovascular and mental health, were linked to lower odds of female infertility. However, adding depression to the LE8 framework did not significantly improve its predictive value.

29 Apr 2025

Even small workouts can help protect the aging brain

Good fitness can reduce the risk of dementia and promote healthy brain aging. This recognition should be included in updated health recommendations, say researchers behind the new review.

29 Apr 2025

Study connects low birth weight to reduced adult physical activity

Poorer gross motor skills, such as the ability to walk quickly, run, or jump, may explain some of the correlation between being born prematurely and the tendency to engage less in physical activity.

29 Apr 2025