Molecular & Structural Biology

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Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine have begun to unravel the mystery of how acidity influences a small protein called serum amyloid A (SAA).

28 Jul 2017

Molecule plays essential role in establishing proper neural wiring in the cerebellum

Researchers at Hokkaido University have found that the molecule "L-gutamate/L-aspartate transporter" (GLAST) plays an essential role in establishing and maintaining proper neural wiring of Purkinje cells in the cerebellum.

28 Jul 2017

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

How can six and half feet of DNA be folded into the tiny nucleus of a cell? Researchers funded by the National Institutes of Health have developed a new imaging method that visualizes a very different DNA structure, featuring small folds of DNA in close proximity.

27 Jul 2017

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

Antibiotic resistance of the bacterium Staphylococcus aureus is responsible for 11,300 deaths a year in the United States alone -- a figure that corresponds to half of all deaths caused by gram-positive resistant bacteria in that country.

26 Jul 2017

Molecular classification of gastric cancer subtypes could shape tailored treatment options

Molecular classification of the four distinct subtypes of gastric cancer could potentially shape tailored treatment options by helping to predict survival outcomes and patients' response to chemotherapy.

26 Jul 2017

Scientists find hints to a 'ghost' species of archaic humans in saliva

In saliva, scientists have found hints that a "ghost" species of archaic humans may have contributed genetic material to ancestors of people living in Sub-Saharan Africa today.

21 Jul 2017

Highly intricate visual system arises from simple blueprint present at birth, findings suggest

For decades, researchers have known that the primate brain is organized into "maps" for each of the different senses: one of the body for touch, one of the visual world for sight, one of tones for hearing.

19 Jul 2017

Unique 'Golden Hour' study details ultra-early immune response to trauma

Scientists from the University of Birmingham are carrying out pioneering research as part of a major £10 million study aimed at improving outcomes for patients who have suffered a traumatic injury.

19 Jul 2017

Researchers study molecular mechanisms responsible for Alzheimer's disease

Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex, formed in the brain at the early stages of Alzheimer's disease progression.

14 Jul 2017

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

The researchers from Harvard University, Seth L. Shipman, Jeff Nivala, Jeffrey D. Macklis and George M. Church, believe that their study is a major step forward to a "molecular recorder" that may someday make it possible to get read-outs, has published online their proof-of-concept on July 12, 2017, in the journal Nature.

14 Jul 2017

New technique reveals detailed structure of sweat glands

The basic structure of human sweat glands consists of a coiled secretory region deep in the skin and then a tube or duct that conveys the sweat to a pore at the skin surface.

10 Jul 2017

Novel technique analyzes sperm morphology and motility in embryo formation process

The research, presented at the European Society of Human Reproduction and Embryology annual conference, which ends today in Geneva, Switzerland, describes for the first time the use of an experimental technique that has made it possible to analyze the functioning of human sperm in contact with the cytoplasmic content of the eggs in vitro.

7 Jul 2017

Researchers discover how new molecular scissors unzip and cleave DNA with high accuracy

Researchers from the University of Copenhagen (Denmark), led by the Spanish researcher Guillermo Montoya, have discovered how Cpf1, new molecular scissors unzip and cleave DNA.

6 Jul 2017

Scientists provide detailed view of tau protein structures found in Alzheimer's disease

New research by scientists at the MRC Laboratory of Molecular Biology in the United Kingdom and Indiana University School of Medicine gives the most detailed view yet of tau protein structures found in Alzheimer's disease.

6 Jul 2017

Study indicates new element involved in genome instability

Genome instability is the main risk factor in the development of tumours in humans. Understanding how, where, when and why these mutations are produced in DNA is one of the great objectives of the global scientific community.

30 Jun 2017

Research provides new insights into how telomeres regulate cellular senescence

Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have further uncovered the secrets of telomeres, the caps that protect the ends of our chromosomes.

30 Jun 2017

Research presents crystal structure of enzyme implicated in cancer, neurodegenerative diseases

A Stony Brook University-led team of researchers has determined the structure of a key enzyme involved with cell growth regulation in cancer and neurodegenerative diseases, including Alzheimer's disease.

28 Jun 2017

Morgridge researchers reveal complex viral replication process in unprecedented detail

In the fight against the viruses that invade everyday life, seeing and understanding the battleground is essential. Scientists at the Morgridge Institute for Research have, for the first time, imaged molecular structures vital to how a major class of viruses replicates within infected cells.

27 Jun 2017

Researchers develop new technique to capture neuron activity

Many cognitive processes, such as decision-making, take place within seconds or minutes. Neuroscientists have longed to capture neuron activity during such tasks, but that dream has remained elusive -- until now.

27 Jun 2017

Researchers uncover three-dimensional structure of tetanus toxin protein

"Our discovery could be used to design new medicines", says Pål Stenmark, Associate Professor at the Department of Biochemistry and Biophysics, Stockholm University.

27 Jun 2017

Molecular & Structural Biology

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Molecule plays essential role in establishing proper neural wiring in the cerebellum

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

Molecular classification of gastric cancer subtypes could shape tailored treatment options

Scientists find hints to a 'ghost' species of archaic humans in saliva

Highly intricate visual system arises from simple blueprint present at birth, findings suggest

Unique 'Golden Hour' study details ultra-early immune response to trauma

Researchers study molecular mechanisms responsible for Alzheimer's disease

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

New technique reveals detailed structure of sweat glands

Novel technique analyzes sperm morphology and motility in embryo formation process

Researchers discover how new molecular scissors unzip and cleave DNA with high accuracy

Scientists provide detailed view of tau protein structures found in Alzheimer's disease

Study indicates new element involved in genome instability

Research provides new insights into how telomeres regulate cellular senescence

Research presents crystal structure of enzyme implicated in cancer, neurodegenerative diseases

Morgridge researchers reveal complex viral replication process in unprecedented detail

Researchers develop new technique to capture neuron activity

Researchers uncover three-dimensional structure of tetanus toxin protein

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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