Molecular & Structural Biology

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Understanding why respiratory infections are more common in the winter

Researchers investigate the role of extracellular vesicles in the innate nasal mucosal response to several respiratory viruses.

6 Dec 2022

Study predicts persistent cross-species SARS-CoV-2 variant infectivity

Scientists believe bats first transmitted SARS-CoV-2 to humans in December 2019, and while the virus has since evolved into several variants such as delta and omicron, a new study indicates the virus is still highly transmissible between mammals.

5 Dec 2022

Researchers use loop-seq technology to decipher the mechanical code of DNA

A new study has deciphered the mechanical code of DNA to reveal previously unknown ways in which nature encodes biological information in DNA sequence.

5 Dec 2022

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

The German Research Foundation (DFG) has approved the establishment and funding of the Collaborative Research Center/Transregio (CRC/TRR) 355 "Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments".

2 Dec 2022

Study implicates a specific type of brain cell as key player underlying the impact of stressors

More than 70% of adults will experience at least one traumatic experience, such as a life-threatening illness or accident, violent assault or natural disaster, in their lifetimes and nearly a third will experience four or more, according to global data.

1 Dec 2022

Study reveals key details of how DREADD technology highjacks neuronal activity

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance abuse, epilepsy, and others.

30 Nov 2022

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Researchers at the University of California, Irvine have discovered that removal of cilia from the brain's striatum region impaired time perception and judgment, revealing possible new therapeutic targets for mental and neurological conditions including schizophrenia, Parkinson's and Huntington's diseases, autism spectrum disorder, and Tourette syndrome.

30 Nov 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

CSU engineers introduce a better way to perform mosquito-tracking for disease applications

West Nile, Zika, dengue and malaria are all diseases spread by bites from infected mosquitoes. To track the threat of such diseases over large populations, scientists need to know where the mosquitoes are, where they've been, and where they might go.

30 Nov 2022

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

Gross anatomy reveals three-dimensional shapes of pathology at a large scale. Histology, in contrast, reveals the microscopic anatomy of biological structures. But that magnification comes at a cost - histology shows only two-dimensional shapes because it studies small, flat slices of stained tissue.

29 Nov 2022

MicroRNAs play a key role in the development of complex brains

Cephalopods like octopuses, squids and cuttlefish are highly intelligent animals with complex nervous systems.

25 Nov 2022

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now.

24 Nov 2022

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

With the continuous emergence of new variants and the risk of new strains of the virus, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge.

23 Nov 2022

MYC proteins form hollow spheres that shield the genome of cancer cells

MYC genes and their proteins play a central role in the emergence and development of almost all cancers. They drive the uncontrolled growth and altered metabolism of tumour cells. And they help tumours hide from the immune system.

23 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Researchers make an incredible discovery about mammalian brains

In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery.

23 Nov 2022

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Dr. Benjamin Rotstein and collaborators unveil an operationally simple method to prepare carbon isotope-labeled versions of drugs and diagnostics.

22 Nov 2022

New family of adeno-associated viral vectors found to be better at delivering genetic cargo

Gene therapies can treat, even potentially cure, certain genetic diseases, but it is challenging to deliver the treatments to the parts of the body where they are needed.

22 Nov 2022

Unique resource for identifying new biomarkers of environmental exposures in early life

Researchers now have a unique resource for identifying new biomarkers of environmental exposures in early life and understanding their health effects.

22 Nov 2022

Molecular & Structural Biology

Understanding why respiratory infections are more common in the winter

Study predicts persistent cross-species SARS-CoV-2 variant infectivity

Researchers use loop-seq technology to decipher the mechanical code of DNA

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

Study implicates a specific type of brain cell as key player underlying the impact of stressors

Study reveals key details of how DREADD technology highjacks neuronal activity

Removal of cilia from the brain's striatum impairs time perception and judgment, study finds

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

New guidelines for designing synthetic molecules that block interaction between two proteins

CSU engineers introduce a better way to perform mosquito-tracking for disease applications

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

MicroRNAs play a key role in the development of complex brains

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

MYC proteins form hollow spheres that shield the genome of cancer cells

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Researchers make an incredible discovery about mammalian brains

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

New family of adeno-associated viral vectors found to be better at delivering genetic cargo

Unique resource for identifying new biomarkers of environmental exposures in early life

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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