Molecular & Structural Biology

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Researchers discover unique regenerative property of cells in the early human embryo

Pioneering research led by experts from the University of Exeter's Living Systems Institute has provided new insight into formation of the human embryo.

8 Apr 2021

Mouse model provides new understanding about Folling Disease

In Norway, all newborn children are tested for 25 rare genetic diseases through the Newborn Screening program, and the most common of these is phenylketonuria (abbreviated to PKU), known as Folling Disease.

7 Apr 2021

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions.

7 Apr 2021

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife.

6 Apr 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Researchers generate a precise map of basal ganglia connectivity

Thousands of our daily activities, from making coffee to taking a walk to saying hello to a neighbor, are made possible through an ancient collection of brain structures tucked away near the center of the cranium.

5 Apr 2021

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others.

5 Apr 2021

Study sheds new light on the evolution of mammalian brain size

A new study has revealed a surprising lack of support for widely-held explanations of why some mammals evolve larger brains than expected for their body size.

1 Apr 2021

Protein could be key to blocking the most common bacterial cause of food poisoning

Washington State University researchers have discovered a protein that could be key to blocking the most common bacterial cause of human food poisoning in the United States.

30 Mar 2021

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

A study conducted at the University of Campinas in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines.

30 Mar 2021

Researchers create novel light sensor from algae's rhodopsins

The unicellular green alga Chlamydomonas reinhardtii has already given research a massive boost: One of its light sensors, channelrhodopsin-2, founded the success of optogenetics about 20 years ago.

30 Mar 2021

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Why do some people with cold sores around their lips experience painful lesions, while others have no symptoms at all, yet still spread the virus? A new study conducted at Penn State finds that these differences could be due to variations in the way certain strains of herpes simplex (HSV-1) -- the virus that causes cold sores, as well as genital herpes -- activate gene expression in neurons.

29 Mar 2021

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

University of Birmingham researchers are working to isolate and extract the COVID-19 encounter complex in a form that is stable enough for identification of target sites for future anti-viral drugs.

27 Mar 2021

Researchers identify neural circuit involved in reciprocally regulating weight gain and depression

Research has found that obesity and mental disorders such as depression and anxiety seem to often go hand in hand.

26 Mar 2021

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Leigh syndrome is the most severe mitochondrial disease in children. It causes severe muscle weakness, movement defects, and intellectual disabilities.

26 Mar 2021

Research sheds light on a new neuroprotective mechanism to control damage following brain injury

When the brain suffers injury or infection, glial cells surrounding the affected site act to preserve the brain's sensitive nerve cells and prevent excessive damage.

26 Mar 2021

Salk joins a long list of recipients included in The Conrad Prebys Foundation’s inaugural grant cycle

Salk Professor Thomas Albright has been awarded $1 million and Assistant Professor Edward Stites awarded $500,000 by The Conrad Prebys Foundation as part of its inaugural round of grants.

26 Mar 2021

Scientists reveal molecular mechanisms involved in eliminating unwanted body cells

Scientists at the Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have revealed molecular mechanisms involved in eliminating unwanted cells in the body.

26 Mar 2021

Scientists describe the mechanisms that regulate embryonic stem cells

Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best possible state for their use in regenerative medicine.

26 Mar 2021

Researchers characterize a potential therapeutic target to weaken COVID-19

When invaded by a virus, our body cells launch an alert to neighboring cells to increase their antiviral defenses to prevent the infection from spreading.

24 Mar 2021

Molecular & Structural Biology

Researchers discover unique regenerative property of cells in the early human embryo

Mouse model provides new understanding about Folling Disease

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Researchers generate a precise map of basal ganglia connectivity

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Study sheds new light on the evolution of mammalian brain size

Protein could be key to blocking the most common bacterial cause of food poisoning

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

Researchers create novel light sensor from algae's rhodopsins

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

Researchers identify neural circuit involved in reciprocally regulating weight gain and depression

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Research sheds light on a new neuroprotective mechanism to control damage following brain injury

Salk joins a long list of recipients included in The Conrad Prebys Foundation’s inaugural grant cycle

Scientists reveal molecular mechanisms involved in eliminating unwanted body cells

Scientists describe the mechanisms that regulate embryonic stem cells

Researchers characterize a potential therapeutic target to weaken COVID-19

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

Evolving spectrophotometry for modern biopharma workflows

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