Molecular & Structural Biology

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Study offers explanation for why people's responses to the same drug vary widely

Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.

1 Oct 2020

Direction and type of the force acting on a cell can alter gene expression

Tissues and cells in the human body are subjected to a constant push and pull - strained by other cells, blood pressure and fluid flow, to name a few.

1 Oct 2020

Scientists map genetic networks that control the biology of regulatory T cells

Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they're not needed.

1 Oct 2020

Researchers unravel new mechanism of cell survival in chronic lymphocytic leukemia

Researchers at The Wistar Institute unraveled a mechanism employed by chronic lymphocytic leukemia (CLL) cells for their survival.

30 Sep 2020

Researchers identify the target structures for T-cell response against SARS-CoV-2

Our immune system can efficiently fend off viral diseases. Two types of immune cells play an important role in this process: The T-cells, which firstly can directly destroy virus-infected cells and secondly enable the formation of efficient, virus-neutralizing antibodies by B-cells.

30 Sep 2020

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from replicating.

30 Sep 2020

Neanderthal gene variant linked to higher risk of developing severe COVID-19

A study published in Nature shows that a segment of DNA that causes their carriers to have an up to three times higher risk of developing severe COVID-19 is inherited from Neandertals. The study was conducted by researchers at Karolinska Institutet and Max Planck Institute for Evolutionary Anthropology.

30 Sep 2020

Study reveals unexpected mechanisms involved in working memory

Working memory: it's how you make a mental shopping list without forgetting the milk, or memorize a number just long enough to write it down.

29 Sep 2020

EPFL scientists measure the molecular footprint of aging

EPFL scientists have measured the molecular footprint that aging leaves on various mouse and human tissues. Using the data, they have identified likely regulators of this central process.

29 Sep 2020

Newly discovered genetic factor allows adult skin to regenerate like a newborn's

A newly identified genetic factor allows adult skin to repair itself like the skin of a newborn babe. The discovery by Washington State University researchers has implications for better skin wound treatment as well as preventing some of the aging process in skin.

29 Sep 2020

Computer model sheds light on how brain circuits might be altered in psychiatric diseases

Scientists have built a computer 'brain circuit', or artificial neural network, that mirrors human decision-making processes and sheds light on how circuits might be altered in psychiatric diseases, a new study published today in eLife reports.

29 Sep 2020

Induction of acute senescence may be a necessary process in hemorrhagic shock

It's called senescence, when stressed cells can no longer divide to make new cells, and it's considered a factor in aging and in some diseases.

29 Sep 2020

Study unravels how lysosomal damage response pathways prevent kidney injury

Human cells need to work like well-oiled machines to keep our bodies running as they should. Waste products such as misfolded proteins, damaged cellular components, and carbohydrates get in the way and must be quickly disposed of.

28 Sep 2020

A new generation of microelectrode-array chips for recording nerve cell impulses

ETH researchers have developed a new generation of microelectrode-array chips for measuring nerve impulses, enabling studies of how thousands of nerve cells interact with each other.

28 Sep 2020

Evolutionary and heritable axes shape the organization of brain structure

Every region has its place in the brain. However, it has been unclear why brain regions are located where they are.

28 Sep 2020

Epigenetic changes in the brain drive late-onset Alzheimer's disease

New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics.

28 Sep 2020

Researchers gain deep insights into the structure of birds’ brains

Some birds can perform amazing cognitive feats – even though their forebrains seem to just consist of lumps of grey cells, while mammalian forebrains harbour a highly complex neocortex.

26 Sep 2020

Researchers develop a stable nano-carrier for medications

Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells.

25 Sep 2020

New optical switch to precisely control the lifespan of genetic 'copies'

A novel optical switch makes it possible to precisely control the lifespan of genetic "copies". These are used by the cell as building instructions for the production of proteins.

25 Sep 2020

Study identifies potential drug target for dangerous E. coli infections

Escherichia coli, known as E. coli, are bacteria which many people associate with causing mild food poisoning, but some types of E. coli can be fatal.

25 Sep 2020

Molecular & Structural Biology

Study offers explanation for why people's responses to the same drug vary widely

Direction and type of the force acting on a cell can alter gene expression

Scientists map genetic networks that control the biology of regulatory T cells

Researchers unravel new mechanism of cell survival in chronic lymphocytic leukemia

Researchers identify the target structures for T-cell response against SARS-CoV-2

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Neanderthal gene variant linked to higher risk of developing severe COVID-19

Study reveals unexpected mechanisms involved in working memory

EPFL scientists measure the molecular footprint of aging

Newly discovered genetic factor allows adult skin to regenerate like a newborn's

Computer model sheds light on how brain circuits might be altered in psychiatric diseases

Induction of acute senescence may be a necessary process in hemorrhagic shock

Study unravels how lysosomal damage response pathways prevent kidney injury

A new generation of microelectrode-array chips for recording nerve cell impulses

Evolutionary and heritable axes shape the organization of brain structure

Epigenetic changes in the brain drive late-onset Alzheimer's disease

Researchers gain deep insights into the structure of birds’ brains

Researchers develop a stable nano-carrier for medications

New optical switch to precisely control the lifespan of genetic 'copies'

Study identifies potential drug target for dangerous E. coli infections

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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