Molecular & Structural Biology

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MGH researchers uncover new clues about X chromosome inactivation

Researchers at Massachusetts General Hospital have uncovered new clues that add to the growing understanding of how female mammals, including humans, "silence" one X chromosome.

15 Mar 2021

Random cellular changes play vital role in longevity beyond genetics and environment

A new model of aging takes into account not only genetics and environmental exposures but also the tiny changes that randomly arise at the cellular level.

13 Mar 2021

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

An enzyme called MARK2 has been identified as a key stress-response switch in cells in a study by researchers at Johns Hopkins Bloomberg School of Public Health.

11 Mar 2021

Researchers unveil new technique for observing metabolic processes in real time

Magnetic resonance imaging (MRI) is already widely used in medicine for diagnostic purposes. Hyperpolarized MRI is a more recent development and its research and application potential has yet to be fully explored.

11 Mar 2021

Unbalanced progesterone may cause preterm or prolonged labor in some pregnant women

New research by the National Institutes of Health found that unbalanced progesterone signals may cause some pregnant women to experience preterm labor or prolonged labor.

11 Mar 2021

Princeton researchers elucidate how hepatitis B virus establishes chronic infection

Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV).

11 Mar 2021

Study reveals how lung alveolus forms at cellular level

Researchers from Children's Hospital of Philadelphia have determined what happens at a cellular level as the lung alveolus forms and allows newborns to breathe air.

11 Mar 2021

Research shows how humans have sensitive and accurate sense of touch

Fingerprints may be more useful to us than helping us nab criminal suspects: they also improve our sense of touch. Sensory neurons in the finger can detect touch on the scale of a single fingerprint ridge, according to new research published in JNeurosci.

11 Mar 2021

Mosquito protein study could lead to therapeutics against deadly viruses

The mosquito protein AEG12 strongly inhibits the family of viruses that cause yellow fever, dengue, West Nile, and Zika and weakly inhibits coronaviruses, according to scientists at the National Institutes of Health (NIH) and their collaborators.

10 Mar 2021

Researchers shed light on T-cell receptor activation in response to infection

Immune cells specialize to ensure the most efficient defense against viruses and other pathogens. Researchers at the University of Basel have shed light on this specialization of T cells and shown that it occurs differently in the context of an acute and a chronic infection.

10 Mar 2021

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.

9 Mar 2021

Princeton researchers discover previously unknown organelle that plays role in bone metastasis

Some of Princeton's leading cancer researchers were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body -- metastasis -- turned up evidence of liquid-liquid phase separations: the new field of biology research that investigates how liquid blobs of living materials merge into each other, similar to the movements seen in a lava lamp or in liquid mercury.

9 Mar 2021

Inhibition of complement disrupts neurodegeneration, improves cognitive function in TBI patients

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven neuroinflammation.

9 Mar 2021

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria.

5 Mar 2021

A small sensor can be used for rapid detection of RNA and DNA

In less than a second, a small sensor used in brain chemistry research can detect the key molecules that provide the genetic instructions for life, RNA, and DNA, a new study from American University shows

5 Mar 2021

Study demonstrates the impact of 'reverse antibiotic' on gram-negative bacteria

Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy.

5 Mar 2021

Structural insights into glycine transporter open new avenues to find effective psychiatric drugs

Glycine can stimulate or inhibit neurons in the brain, thereby controlling complex functions. Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain.

4 Mar 2021

Molecular & Structural Biology

MGH researchers uncover new clues about X chromosome inactivation

Random cellular changes play vital role in longevity beyond genetics and environment

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

Researchers unveil new technique for observing metabolic processes in real time

Unbalanced progesterone may cause preterm or prolonged labor in some pregnant women

Princeton researchers elucidate how hepatitis B virus establishes chronic infection

Study reveals how lung alveolus forms at cellular level

Research shows how humans have sensitive and accurate sense of touch

Mosquito protein study could lead to therapeutics against deadly viruses

Researchers shed light on T-cell receptor activation in response to infection

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

Princeton researchers discover previously unknown organelle that plays role in bone metastasis

Inhibition of complement disrupts neurodegeneration, improves cognitive function in TBI patients

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

A small sensor can be used for rapid detection of RNA and DNA

Study demonstrates the impact of 'reverse antibiotic' on gram-negative bacteria

Structural insights into glycine transporter open new avenues to find effective psychiatric drugs

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Analytical Mass Spectrometry: How Did We Get Here, Where are We Going?

Study reveals how cells build 'mini-muscles' underneath their nucleus

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

Evolving spectrophotometry for modern biopharma workflows

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