Molecular & Structural Biology

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In vivo imaging reveals how anti-CD20 antibodies guide the immune system to attack tumors

Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called "immunotherapies." But how do these antibodies function within the tumor? And how can we hope to improve their efficacy?

22 Feb 2021

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Coronaviruses exploit our cells so they can make copies of themselves inside us. After they enter our cells, they use our cell machinery to make unique tools of their own that help them generate these copies.

22 Feb 2021

Study reveals mechanism for translation of maternally inherited mitochondrial genome

An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome.

22 Feb 2021

Researchers uncover 'hotspots' on the Spike protein that are critical for SARS-CoV-2 infection

The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics.

22 Feb 2021

Neurons activated by visual stimulus keep more active during subsequent sleep, study shows

When you slip into sleep, it's easy to imagine that your brain shuts down, but University of Michigan research suggests that groups of neurons activated during prior learning keep humming, tattooing memories into your brain.

22 Feb 2021

Novel vectors reduce the risks associated with ocular gene therapies

Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development.

22 Feb 2021

Rest during holidays has a restorative effect on DNA changes in shift workers with sleep disorder

Long-term sleep deprivation is detrimental to health, increasing the risk of psychiatric and somatic disorders, such as depression and cardiovascular diseases.

22 Feb 2021

Researchers study how the methylation of proteins affects different mitochondrial processes

Disorders of the cells' energy supply can cause a number of serious diseases, but also seem to be connected to aging.

20 Feb 2021

Study provides new information about the structure of prion proteins

Prion diseases are a group of rapidly progressive, fatal and infectious neurodegenerative disorders affecting both humans and animals: Bovine Spongiform Encephalopathy (BSE) or 'mad cow' disease is one of the most famous since in 1996 scientists found that the agent responsible for the disease in cows, is the same agent responsible for the so-called variant Creutzfeldt-Jakob Disease (vCJD), a disease affecting humans.

20 Feb 2021

Study: Longevity gene protects brain stem cells from the harmful effects of stress

A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators.

20 Feb 2021

Researchers discover first evidence of protein folding driven by liquid-liquid phase separation

Scientists have discovered the first evidence of protein folding driven by liquid-liquid phase separation, a phenomenon in which fluids form into microscopic droplets and separate inside cells -- like drops of oil in water.

20 Feb 2021

Meta-study provides an overall picture of the neural basis of sign language

The ability to speak is one of the essential characteristics that distinguishes humans from other animals. Many people would probably intuitively equate speech and language.

20 Feb 2021

Transforming immune killer T-cells into 'super soldiers' to fight against cancer

Creating "super soldiers" of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.

20 Feb 2021

Researchers find new way to enhance the sensitivity of electrochemical micro-sensors

A team led by researchers at the New York University Tandon School of Engineering have found a new way of enhancing the performance of electrochemical micro-sensors.

20 Feb 2021

3D microscopy analysis provides accurate recreation of human glioblastoma’s features

Researchers at the Institut de Neurociències obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis

19 Feb 2021

Researchers develop new tool to decipher cellular conversations

An interdisciplinary team of biologists and mathematicians at the University of California, Irvine has developed a new tool to help decipher the language cells use to communicate with one another.

18 Feb 2021

Researchers use high-resolution imaging to observe HIV infection process in the cell nucleus

Scientists at EMBL Heidelberg and at the Zentrum für Infektiologie at Heidelberg University Hospital have succeeded for the first time in imaging HIV during transport into the nucleus of an infected cell.

18 Feb 2021

Modified therapeutic molecule enhances stroke treatment

A research team from the Institut national de la recherche scientifique (INRS) has improved the protective effect of a molecule against ischemic stroke, which is caused by an interruption of blood flow to the brain.

18 Feb 2021

Novel hydrogel slowly releases RNA nanovaccines to shrink tumors

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer.

17 Feb 2021

Researchers identify molecular link between inflammatory signaling molecule and a main oncogene

A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signaling molecule and one of the main oncogenes.

17 Feb 2021

Molecular & Structural Biology

In vivo imaging reveals how anti-CD20 antibodies guide the immune system to attack tumors

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Study reveals mechanism for translation of maternally inherited mitochondrial genome

Researchers uncover 'hotspots' on the Spike protein that are critical for SARS-CoV-2 infection

Neurons activated by visual stimulus keep more active during subsequent sleep, study shows

Novel vectors reduce the risks associated with ocular gene therapies

Rest during holidays has a restorative effect on DNA changes in shift workers with sleep disorder

Researchers study how the methylation of proteins affects different mitochondrial processes

Study provides new information about the structure of prion proteins

Study: Longevity gene protects brain stem cells from the harmful effects of stress

Researchers discover first evidence of protein folding driven by liquid-liquid phase separation

Meta-study provides an overall picture of the neural basis of sign language

Transforming immune killer T-cells into 'super soldiers' to fight against cancer

Researchers find new way to enhance the sensitivity of electrochemical micro-sensors

3D microscopy analysis provides accurate recreation of human glioblastoma’s features

Researchers develop new tool to decipher cellular conversations

Researchers use high-resolution imaging to observe HIV infection process in the cell nucleus

Modified therapeutic molecule enhances stroke treatment

Novel hydrogel slowly releases RNA nanovaccines to shrink tumors

Researchers identify molecular link between inflammatory signaling molecule and a main oncogene

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

Evolving spectrophotometry for modern biopharma workflows

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