Molecular & Structural Biology

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Tiny SARS-CoV-2 protein may have big implications for future COVID-19 treatments

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

9 Apr 2021

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.

9 Apr 2021

Researchers identify nonelectrical cells that transition the brain from plasticity to stability

Researchers exploring the developing central nervous system of fruit flies have identified nonelectrical cells that transition the brain from highly plastic into a less moldable, mature state.

8 Apr 2021

Mutations to autism-associated gene cause a cascade of problems in developing mouse brains

Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average brain size, and, eventually, autism-like behaviors, a new study from Scripps Research, Florida, finds.

8 Apr 2021

Researchers discover unique regenerative property of cells in the early human embryo

Pioneering research led by experts from the University of Exeter's Living Systems Institute has provided new insight into formation of the human embryo.

8 Apr 2021

Mouse model provides new understanding about Folling Disease

In Norway, all newborn children are tested for 25 rare genetic diseases through the Newborn Screening program, and the most common of these is phenylketonuria (abbreviated to PKU), known as Folling Disease.

7 Apr 2021

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions.

7 Apr 2021

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife.

6 Apr 2021

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre have discovered how certain proteins ensure the repair of errors introduced into the DNA during its replication.

6 Apr 2021

Researchers generate a precise map of basal ganglia connectivity

Thousands of our daily activities, from making coffee to taking a walk to saying hello to a neighbor, are made possible through an ancient collection of brain structures tucked away near the center of the cranium.

5 Apr 2021

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others.

5 Apr 2021

Study sheds new light on the evolution of mammalian brain size

A new study has revealed a surprising lack of support for widely-held explanations of why some mammals evolve larger brains than expected for their body size.

1 Apr 2021

Protein could be key to blocking the most common bacterial cause of food poisoning

Washington State University researchers have discovered a protein that could be key to blocking the most common bacterial cause of human food poisoning in the United States.

30 Mar 2021

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

A study conducted at the University of Campinas in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines.

30 Mar 2021

Researchers create novel light sensor from algae's rhodopsins

The unicellular green alga Chlamydomonas reinhardtii has already given research a massive boost: One of its light sensors, channelrhodopsin-2, founded the success of optogenetics about 20 years ago.

30 Mar 2021

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Why do some people with cold sores around their lips experience painful lesions, while others have no symptoms at all, yet still spread the virus? A new study conducted at Penn State finds that these differences could be due to variations in the way certain strains of herpes simplex (HSV-1) -- the virus that causes cold sores, as well as genital herpes -- activate gene expression in neurons.

29 Mar 2021

Molecular & Structural Biology

Tiny SARS-CoV-2 protein may have big implications for future COVID-19 treatments

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

Researchers identify nonelectrical cells that transition the brain from plasticity to stability

Mutations to autism-associated gene cause a cascade of problems in developing mouse brains

Researchers discover unique regenerative property of cells in the early human embryo

Mouse model provides new understanding about Folling Disease

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Scientists use cryo-electron microscopy to unravel how 'guardian' of the genome works

Researchers generate a precise map of basal ganglia connectivity

Discovering DNA methylation from bacteria and microbiome using nanopore technology

Study sheds new light on the evolution of mammalian brain size

Protein could be key to blocking the most common bacterial cause of food poisoning

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

Researchers create novel light sensor from algae's rhodopsins

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

Researchers identify neural circuit involved in reciprocally regulating weight gain and depression

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Research sheds light on a new neuroprotective mechanism to control damage following brain injury

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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