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Long-term Warfarin use may increase dementia rates in AF patients

A new study of more than 10,000 patients treated long term with the blood thinner, Warfarin, reveals higher rates of dementia for patients with atrial fibrillation versus non-AF patients

5 May 2016

Study shows short-term statin treatment does not benefit heart surgery patients

Giving daily doses of statins for a few days before and after heart surgery does not prevent heart muscle damage or the development of atrial fibrillation (AF), according to an international clinical trial led by the University of Oxford and funded by the British Heart Foundation.

5 May 2016

Perfect nano-capsules for targeted drug delivery may become possible in future

By now, the research is quite fundamental. However, one of the authors, Igor Potemkin argues that the creation of the perfect nano-capsules for targeted drug deliverywould be possibleon the basis of the reported system in the nearest years, and the production will be relatively cheap.

5 May 2016

Older women at increased risk of receiving inappropriate prescription medicines, study shows

Nearly one in three British Columbia women over age 65 received inappropriate prescription medicines in 2013, according to a University of British Columbia study. One in four men of the same age received similar prescriptions.

5 May 2016

Antiviral therapies equal survival rate of HCV-related cirrhosis patients with general population

The survival rate of patients with hepatitis C virus-related cirrhosis who respond well to antiviral therapies equals that of the general population, say investigators in the Journal of Hepatology.

5 May 2016

Michigan researchers use 'kidney on a chip' device to measure effect of drug doses on kidney cells

University of Michigan researchers have used a "kidney on a chip" device to mimic the flow of medication through human kidneys and measure its effect on kidney cells.

5 May 2016

Bayer-new phase 3 liver cancer data

Bayer has announced that a Phase III trial evaluating its oncology compound Stivarga® (regorafenib) tablets for the treatment of patients with unresectable hepatocellular carcinoma (HCC) has met its primary endpoint of a statistically significant improvement in overall survival. The study, called RESORCE, evaluated the efficacy and safety of regorafenib in patients with HCC whose disease has progressed after treatment with sorafenib. The safety and tolerability were generally consistent with the known profile of regorafenib. Detailed efficacy and safety analyses from this study are expected to be presented at an upcoming scientific congress.

4 May 2016

Finding treatments for rare diseases: an interview with Dr Richard Thompson

It is estimated that around 400 rare diseases have licenced treatments, and a large proportion of these are a consequence of orphan drug legislation, which has helped to incentivise the production of drugs for small patient populations.

4 May 2016

Study evaluates effects of corticosteroids along with anti-tuberculosis drugs in tuberculous meningitis

The Cochrane Infectious Diseases Group have carried out a review update to evaluate the effects of corticosteroids being used alongside anti-tuberculosis medication to treat people suffering from tuberculous meningitis.

4 May 2016

Researchers find gene variants that predict adverse effects of hyperthyroidism drugs

Researchers and doctors at Uppsala University, along with Swedish and international collaboration partners, have found gene variants that predict the risk of a serious adverse reaction to drugs used for the treatment of hyperthyroidism. The results are published in The Lancet Diabetes & Endocrinology.

4 May 2016

Study estimates 30% of outpatient oral antibiotic prescription in the U.S as inappropriate

An estimated 30 percent of outpatient oral antibiotic prescriptions in the U.S. in 2010-2011 may have been inappropriate, findings that support the need for establishing a goal for outpatient antibiotic stewardship, according to a study appearing in the May 3 issue of JAMA.

4 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Scientists identify novel way of synthesising promising new antibiotic

A novel way of synthesising a promising new antibiotic has been identified by scientists at the University of Bristol. By expressing the genes involved in the production of pleuromutilin in a different type of fungus, the researchers were able to increase production by more than 2,000 per cent.

4 May 2016

Diabetes risk linked to increased dosage, duration and timing of steroids

Glucocorticoid (or steroid) therapy, prescribed to around half of patients with rheumatoid arthritis, is a known risk factor for developing diabetes. A study from The University of Manchester has found how the risk of diabetes increases in relation to the dosage, duration and timing of steroids.

4 May 2016

High doses of Imodium to self-treat opioid addictions could be extremely dangerous

The over-the-counter anti-diarrhea medication Imodium, or its key ingredient loperamide, is increasingly being abused by people attempting to self-treat their opioid addiction, with sometime fatal results.

4 May 2016

Study assesses effect of chemoradiotherapy on survival of locally advanced pancreatic cancer patients

In a study appearing in the May 3 issue of JAMA, Pascal Hammel, M.D., of Beaujon Hospital, Clichy, France and colleagues assessed whether chemoradiotherapy improves overall survival of patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine-based induction chemotherapy, and assessed the effect of erlotinib on survival. Gemcitabine and erlotinib are drugs used to treat cancer.

4 May 2016

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Aging takes its toll on the brain, and the cells of the hippocampus--a brain region with circuitry crucial to learning and memory--are particularly vulnerable to changes that can lead to Alzheimer's disease or cognitive decline. With the hope of counteracting the changes that can lead to these two conditions, researchers at Rockefeller University and their colleagues have begun examining the effects of a drug known to affect this circuitry.

4 May 2016

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report.

3 May 2016

Study opens door for new opportunities in finding antidotes to nerve agent sarin

The nerve agent sarin causes a deadly overstimulation of the nervous system that can be stopped if treated with an antidote within minutes of poisoning. Today, a ground-breaking study has been published in PNAS, which in detail describes how such a drug works. Researchers at the Swedish Defence Research Agency, Umea University and in Germany are behind the study.

3 May 2016

Flu vaccinations for pregnant women reduce newborn’s influenza risk during first six months of life

Babies whose moms get flu vaccinations while pregnant have a significantly reduced risk of acquiring influenza during their first six months of life, a new study shows, leading the authors to declare that the need for getting more pregnant women immunized is a public health priority.

3 May 2016

Pharmaceutical News

Long-term Warfarin use may increase dementia rates in AF patients

Study shows short-term statin treatment does not benefit heart surgery patients

Perfect nano-capsules for targeted drug delivery may become possible in future

Older women at increased risk of receiving inappropriate prescription medicines, study shows

Antiviral therapies equal survival rate of HCV-related cirrhosis patients with general population

Michigan researchers use 'kidney on a chip' device to measure effect of drug doses on kidney cells

Bayer-new phase 3 liver cancer data

Finding treatments for rare diseases: an interview with Dr Richard Thompson

Study evaluates effects of corticosteroids along with anti-tuberculosis drugs in tuberculous meningitis

Researchers find gene variants that predict adverse effects of hyperthyroidism drugs

Study estimates 30% of outpatient oral antibiotic prescription in the U.S as inappropriate

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Scientists identify novel way of synthesising promising new antibiotic

Diabetes risk linked to increased dosage, duration and timing of steroids

High doses of Imodium to self-treat opioid addictions could be extremely dangerous

Study assesses effect of chemoradiotherapy on survival of locally advanced pancreatic cancer patients

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Study opens door for new opportunities in finding antidotes to nerve agent sarin

Flu vaccinations for pregnant women reduce newborn’s influenza risk during first six months of life

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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