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DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

The active ingredient in an over-the-counter skin cream might do more than prevent wrinkles. Scientists have discovered that the drug, called kinetin, also slows or stops the effects of Parkinson's disease on brain cells.

16 Aug 2013

Scientists uncover potential drug target for effective therapy against bacterial disease brucellosis

UC Davis scientists have uncovered a potential drug target for the development of an effective therapy against the debilitating, chronic form of the bacterial disease brucellosis, which primarily afflicts people in Mediterranean and Middle Eastern countries.

16 Aug 2013

Researchers develop new method that creates libraries of drug candidates, accelerate drug discovery

James Bond had his reasons for ordering his martinis "shaken, not stirred." Similarly, drug manufacturers need to make sure the molecules in a new drug are arranged in an exact manner, lest there be dire consequences. Specifically, they need to be wary of enantiomers, mirror-image molecules composed of the same atoms, but arranged differently.

16 Aug 2013

Preventive antibiotics for HIV patients lower risk of TB or death

As part of the largest international research effort ever made to combat tuberculosis, a team of Johns Hopkins and Brazilian experts has found that preventive antibiotic therapy for people with HIV lowers this group's chances of developing TB or dying.

16 Aug 2013

Neurologists appear unaware of serious safety risks associated with anti-epilepsy drugs

A study by Johns Hopkins researchers shows that a fifth of U.S. neurologists appear unaware of serious drug safety risks associated with various anti-epilepsy drugs, potentially jeopardizing the health of patients who could be just as effectively treated with safer alternative medications.

16 Aug 2013

A*STAR's SIgN discovers new strategy to develop universal dengue vaccine

A new strategy that cripples the ability of the dengue virus to escape the host immune system has been discovered by A*STAR's Singapore Immunology Network. This breakthrough strategy opens a door of hope to what may become the world's first universal dengue vaccine candidate that can give full protection from all four serotypes of the dreadful virus.

14 Aug 2013

Coalition with Innovative Life Sciences delivers best medicine in oncology for cancer patients

GenoSpace, PathGroup and the IP & Science business of Thomson Reuters today announced an innovative initiative to develop and deliver a best-in-class personalized medicine service in oncology, the result of which will enable physicians to make more precise therapeutic recommendations for cancer patients.

13 Aug 2013

Preclinical study reveals pomalidomide shows promising results for treatment of CNS lymphoma

A drug recently approved for use in multiple myeloma is now being tested for its ability to fight central nervous system (CNS) lymphoma, a deadly cancer of the immune system that can affect the brain, spinal cord and fluid, and eyes.

13 Aug 2013

Perrigo Company and Teva Pharmaceutical launch generic equivalent to temozolomide

Teva Pharmaceutical Industries Ltd. and Perrigo Company today announced the launch of the generic equivalent to Temodar (temozolomide).

13 Aug 2013

FDA: New drug Tivicay approved to treat HIV-1 infection

The U.S. Food and Drug Administration today approved Tivicay (dolutegravir), a new drug to treat HIV-1 infection. Tivicay is an integrase strand transfer inhibitor that interferes with one of the enzymes necessary for HIV to multiply.

13 Aug 2013

Bacterial strains that delay cell division might be used to design drugs that stop division entirely

In 1958 a group of scientists working in Denmark made the striking observation that bacterial cells are about twice as large when they are cultured on a rich nutrient source than when they are cultured on a meager one.

13 Aug 2013

Brand-name and generic drug makers take fight to states

The battle concerns state notification laws that would require pharmacists to notify doctors and patients when they substitute generic versions of drugs derived from living organisms known as biologics.

12 Aug 2013

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

3-N-butylphthalide, a green botanical medicine, is a successfully synthesized and stable chemical drug used for the treatment of ischemic stroke that has independent intellectual property rights in China.

12 Aug 2013

Celgene's pomalidomide gets approval in UK for multiple myeloma

Celgene confirmed today that Pomalidomide Celgene▼ (pomalidomide), a new oral blood cancer therapy, has been granted Marketing Authorisation by the European Medicines Agency and is now available in the UK and Ireland.

9 Aug 2013

Drug-related emergency department visits increase among younger adults

A new report by the Substance Abuse and Mental Health Services Administration shows that some drug-related emergency department visits increased by 300 percent -- from 5,605 visits in 2005 to 22,949 visits in 2011. These visits, made by adults aged 18 to 34, were related to the nonmedical use of central nervous system stimulants. On average, about 30 percent of these visits also involved alcohol.

9 Aug 2013

Eisai's investigational compound receives orphan drug designation for cutaneous t-cell lymphoma

Eisai Inc. announced today that the U.S. Food and Drug Administration has granted orphan drug designation to its investigational compound (E7777) for cutaneous t-cell lymphoma. E7777 is designed to have an improved purity profile and manufacturing process.

9 Aug 2013

Investigational malaria vaccine offers protection against malaria infection in healthy adults

An investigational malaria vaccine has been found to be safe, to generate an immune system response, and to offer protection against malaria infection in healthy adults, according to the results of an early-stage clinical trial published Aug. 8 in the journal Science.

9 Aug 2013

Probiotic supplements have no effect on the incidence of diarrhoea in elderly patients

Probiotic supplements given to elderly patients on antibiotics appear to have no effect on the incidence of diarrhoea, a common and sometimes life-threatening side effect of using antibiotics for many elderly patients, according to a new study published in The Lancet.

9 Aug 2013

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

Janssen-Cilag International NV announced today that the European Commission has approved the use of VELCADE (bortezomib) as induction therapy (a first therapeutic option) in combination with dexamethasone or thalidomide and dexamethasone. This licence extension will apply to adult patients with previously-untreated multiple myeloma who are eligible for high-dose chemotherapy with haematological stem cell transplantation.

8 Aug 2013

Pharmaceutical News

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

Kinetin stops the effects of Parkinson's disease on brain cells, say scientists

Scientists uncover potential drug target for effective therapy against bacterial disease brucellosis

Researchers develop new method that creates libraries of drug candidates, accelerate drug discovery

Preventive antibiotics for HIV patients lower risk of TB or death

Neurologists appear unaware of serious safety risks associated with anti-epilepsy drugs

A*STAR's SIgN discovers new strategy to develop universal dengue vaccine

Coalition with Innovative Life Sciences delivers best medicine in oncology for cancer patients

Preclinical study reveals pomalidomide shows promising results for treatment of CNS lymphoma

Perrigo Company and Teva Pharmaceutical launch generic equivalent to temozolomide

FDA: New drug Tivicay approved to treat HIV-1 infection

Bacterial strains that delay cell division might be used to design drugs that stop division entirely

Brand-name and generic drug makers take fight to states

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

Celgene's pomalidomide gets approval in UK for multiple myeloma

Drug-related emergency department visits increase among younger adults

Eisai's investigational compound receives orphan drug designation for cutaneous t-cell lymphoma

Investigational malaria vaccine offers protection against malaria infection in healthy adults

Probiotic supplements have no effect on the incidence of diarrhoea in elderly patients

Janssen receives EC approval to use VELCADE as induction therapy in patients with multiple myeloma

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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