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New insight on ability of certain PAH-derived lesions to evade DNA repair machinery

A person doesn't have to go far to find a polycyclic aromatic hydrocarbon (PAH). These carcinogen precursors are inhaled through automobiles exhaust during the morning commute, are present in a drag of cigarette smoke, and are part of any barbequed meal.

4 Nov 2012

Mass. adopts stricter rules, penalties for compounding pharmacies

The emergency regulations will allow the state to monitor contamination and the volume of medicines being made.

3 Nov 2012

Blog series on global AIDS blueprint interviews NIH investigator

As part of its "Blueprint" series discussing the creation of a U.S. global AIDS blueprint called for by Secretary of State Hillary Clinton in July, the Center for Global Health Policy's "Science Speaks" blog features an interview with Rochelle Walensky, a member of Cost-Effectiveness of Preventing AIDS Complications (CEPAC) and the Office of AIDS Research Advisory Council at the NIH/DHS Panel on Antiretroviral Guidelines for Adults and Adolescents.

3 Nov 2012

November issue of WHO Bulletin available online

The November issue of the WHO Bulletin features an editorial examining the need for a new model for pharmaceutical research, a public health news roundup, a research article examining parental perceptions surrounding polio immunization activities in Karachi, Pakistan, and a paper on the use of evidence to support healthy public policy, among others.

3 Nov 2012

Legislation planned to tighten oversight of compounding pharmacies

Rep. Edward J. Markey, D-Mass., will introduce legislation requiring compounding pharmacies to meet the sterility, record-keeping and manufacturing standards faced by large drug makers.

3 Nov 2012

WHO reports on global diphtheria-tetanus-pertussis vaccination efforts

"Four in five children (83 percent) worldwide received the recommended three doses of diphtheria-tetanus-pertussis (DTP) vaccine during infancy in 2011, according to new data released in the Morbidity and Mortality Weekly Report and in the WHO Weekly Epidemiological Record (WER)," a WHO media note reports.

3 Nov 2012

Bristol-Myers Squibb welcomes decision by NICE to recommend Yervoy for advanced melanoma

Today, Bristol-Myers Squibb is pleased to welcome the decision by The National Institute for Health and Clinical Excellence (NICE) to recommend Yervoy (ipilimumab) for the treatment of previously-treated advanced (unresectable or metastatic) melanoma within the Final Appraisal Determination (FAD).

3 Nov 2012

Data from four Phase 2 trials of AMG 145 to be presented at AHA Scientific Sessions 2012

Amgen will present data from four Phase 2 trials of AMG 145, an investigational fully human monoclonal antibody directed against PCSK9, a protein that reduces the liver's ability to remove low density lipoprotein cholesterol, or "bad" cholesterol from the blood, at the upcoming American Heart Association Scientific Sessions 2012.

3 Nov 2012

MED1 plays a central role in mediating tamoxifen resistance in breast cancer

A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease.

3 Nov 2012

FDA expands Janssen’s Xarelto use to reduce risk of DVT and PE

The U.S. Food and Drug Administration today expanded the approved use of Xarelto (rivaroxaban) to include treating deep vein thrombosis (DVT) or pulmonary embolism (PE), and to reduce the risk of recurrent DVT and PE following initial treatment.

3 Nov 2012

Study results show ongoing comparison of prescription drug costs between US and UK

In the United States, the cost paid for statins (drugs to lower cholesterol) in people under the age of 65 who have private insurance continues to exceed comparable costs paid by the government in the United Kingdom by more than three fold.

3 Nov 2012

NICE decides to recommend Bristol-Myers Squibb’s YERVOY for treatment of advanced melanoma

Bristol-Myers Squibb Company is pleased to announce that today the National Institute of Health and Clinical Excellence (NICE) has decided to recommend YERVOY (ipilimumab), which is approved in the European Union for the treatment of previously-treated metastatic (advanced) melanoma, within the Final Appraisal Determination (FAD).

3 Nov 2012

Adding angiogenesis inhibitor to anti-HER2 drugs extends survival in mice with breast cancer

Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases. In their report published online in PNAS Plus, Massachusetts General Hospital (MGH) investigators report the first preclinical study combining antiangiogenic and anti-HER2 drugs in an animal model of brain metastatic breast cancer.

3 Nov 2012

Physicists to bring to market new drug-discovery tool using genetic sequencing

Today physicists at Wake Forest University and NanoMedica, their biotechnology company partner, received a $700,000 grant from the National Institutes of Health to bring to market a new drug-discovery tool using next-generation genetic sequencing.

3 Nov 2012

Scientists identify biomarker associated with tamoxifen resistance in women with breast cancer

Scientists have identified a molecular 'flag' in women with breast cancer who do not respond or have become resistant to the hormone drug tamoxifen.

From The University of Manchester 3 Nov 2012

Compounding pharmacies rarely get tough punishments; Another firm recalls drugs

USA Today examines how officials have dealt with charges of misconduct at the pharmacies in the past. Meanwhile, a compounding pharmacy, which is owned by the same company that owned the plant linked to the meningitis outbreak, is recalling its products after an FDA review.

2 Nov 2012

XJB-5-131 compound suppresses symptoms of Huntington's in mice

There's new hope in the fight against Huntington's disease. A group of researchers that includes scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

2 Nov 2012

MH6 vaccine shows promise in treating meth addiction

Scientists at The Scripps Research Institute (TSRI) have performed successful tests of an experimental methamphetamine vaccine on rats. Vaccinated animals that received the drug were largely protected from typical signs of meth intoxication.

2 Nov 2012

Antipsychotic drugs associated with increased mortality among people with schizophrenia

Results of a Johns Hopkins study suggest that individuals with schizophrenia are significantly more likely to live longer if they take their antipsychotic drugs on schedule, avoid extremely high doses and also regularly see a mental health professional.

2 Nov 2012

New data: 4 in 5 children received recommended doses of DTP vaccine during infancy in 2011

Four in five children (83%) worldwide received the recommended three doses of diphtheria-tetanus-pertussis (DTP) vaccine during infancy in 2011, according to new data released in the Morbidity and Mortality Weekly Report and in the WHO Weekly Epidemiological Record (WER).

2 Nov 2012

Pharmaceutical News

New insight on ability of certain PAH-derived lesions to evade DNA repair machinery

Mass. adopts stricter rules, penalties for compounding pharmacies

Blog series on global AIDS blueprint interviews NIH investigator

November issue of WHO Bulletin available online

Legislation planned to tighten oversight of compounding pharmacies

WHO reports on global diphtheria-tetanus-pertussis vaccination efforts

Bristol-Myers Squibb welcomes decision by NICE to recommend Yervoy for advanced melanoma

Data from four Phase 2 trials of AMG 145 to be presented at AHA Scientific Sessions 2012

MED1 plays a central role in mediating tamoxifen resistance in breast cancer

FDA expands Janssen’s Xarelto use to reduce risk of DVT and PE

Study results show ongoing comparison of prescription drug costs between US and UK

NICE decides to recommend Bristol-Myers Squibb’s YERVOY for treatment of advanced melanoma

Adding angiogenesis inhibitor to anti-HER2 drugs extends survival in mice with breast cancer

Physicists to bring to market new drug-discovery tool using genetic sequencing

Scientists identify biomarker associated with tamoxifen resistance in women with breast cancer

Compounding pharmacies rarely get tough punishments; Another firm recalls drugs

XJB-5-131 compound suppresses symptoms of Huntington's in mice

MH6 vaccine shows promise in treating meth addiction

Antipsychotic drugs associated with increased mortality among people with schizophrenia

New data: 4 in 5 children received recommended doses of DTP vaccine during infancy in 2011

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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