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CHOP to study antibiotic delivery to children after hospitalization for serious bacterial infection

The Children's Hospital of Philadelphia (CHOP) was awarded nearly $2M in research funding from the Patient-Centered Outcomes Research Institute (PCORI) to study antibiotic delivery to children returning home after hospitalization for a severe bacterial infection.

16 Jan 2013

Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Researchers at the National Institutes of Health (NIH) and Oregon Health & Science University (OHSU) have found that an experimental vaccine elicits antibodies that can protect nonhuman primates from Ebola virus infection.

16 Jan 2013

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Parkinson's experts across the world have been reporting a remarkable phenomenon - many patients treated with drugs to increase the activity of dopamine in the brain as a therapy for motor symptoms such as tremors and muscle rigidity are developing new creative talents, including painting, sculpting, writing, and more.

16 Jan 2013

Pfizer’s Quillivant XR now available in the U.S. for treatment of ADHD

Pfizer Inc. today announced that Quillivant XR (methylphenidate hydrochloride) CII for extended-release oral suspension is now available in the U.S. for the treatment of attention deficit hyperactivity disorder (ADHD).

16 Jan 2013

Diospyrin inactivates a drug target for tuberculosis in new way

A compound from the South African toothbrush tree inactivates a drug target for tuberculosis in a previously unseen way.

16 Jan 2013

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Increased NEK2 gene expression linked to increased drug resistance, faster cancer growth, and poorer patient outcome - The finding may improved diagnostic and prognostic tools for cancer care and could lead to improved cancer therapies

16 Jan 2013

Children with chronic medical conditions more likely to use alternative medicine

Children who regularly see specialists for chronic medical conditions are also using complementary medicine at a high rate, demonstrates recently published research from the University of Alberta and the University of Ottawa.

15 Jan 2013

Multidisciplinary team work on proactive approach to flu vaccine design

An internationally recognized expert in viruses, Robert W. Finberg, MD, the Richard M. Haidack Professor of Medicine and chair and professor of medicine at the University of Massachusetts Medical School, is lead investigator on a $12 million project to develop new ways of predicting how the influenza virus changes and evolves in response to anti-viral drugs and the human immune system. This approach has promise for becoming a pivotal tool in creating a more effective vaccine against the virus.

11 Jan 2013

Additional insights into workings of ALVAC vaccine against HIV

Four years ago, a potential HIV vaccine showed promise against the virus that causes AIDS, but it fell short of providing the broad protection necessary to stem the spread of disease.

11 Jan 2013

Fiscal cliff boosts clinical data registries, but cuts some health care payments

CQ HealthBeat reports on a provision of the fiscal cliff law intended to encourage physicians to submit data to registries that could be a tool to promote better quality care. The Medicare NewsGroup analyzes another provision that changes how payments are calculated for end stage renal disease drugs.

11 Jan 2013

UCSF teams to study new ways to reduce childhood mortality and disease in developing nations

Two UCSF teams have received a total of $16 million from the Bill & Melinda Gates Foundation to study new ways to significantly reduce childhood mortality and disease in developing nations.

11 Jan 2013

Melanomas that develop resistance to vemurafenib also become addicted to the drug

Researchers in California and Switzerland have discovered that melanomas that develop resistance to the anti-cancer drug vemurafenib (marketed as Zelboraf), also develop addiction to the drug, an observation that may have important implications for the lives of patients with late-stage disease.

11 Jan 2013

Cholera could be contained in Haiti by vaccinating less than half the population

Cholera could be contained in Haiti by vaccinating less than half the population, University of Florida researchers suggest in a paper to be published Thursday in the journal Scientific Reports.

11 Jan 2013

FDA requires sleep drugs that contain zolpidem to lower recommended doses

The U.S. Food and Drug Administration today announced it is requiring the manufacturers of Ambien, Ambien CR, Edluar and Zolpimist, widely used sleep drugs that contain the active ingredient zolpidem, to lower current recommended doses. Ambien and Ambien CR are also available as generics.

11 Jan 2013

New guidelines to help fast track radiation oncology drug development

Researchers from the translational research program of the National Cancer Institute and the Radiation Therapy Oncology Therapy Group have developed new guidelines to help fast track the clinical development of targeted cancer drugs in combination with radiation therapy.

11 Jan 2013

Patients at high-risk for recurrent C. difficile with unnecessary antibiotic use

The impact of antibiotic misuse has far-reaching consequences in healthcare, including reduced efficacy of the drugs, increased prevalence of drug-resistant organisms, and increased risk of deadly infections. A new study featured in the February issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, found that many patients with Clostridium difficile infection (C. difficile) are prescribed unnecessary antibiotics, increasing their risk of recurrence of the deadly infection.

10 Jan 2013

LM11A-31 effective at improving limb movement after spinal cord injury in mice

An experimental oral drug given to mice after a spinal cord injury was effective at improving limb movement after the injury, a new study shows.

10 Jan 2013

Mutation that causes sickle cell anemia may offer new way to treat drug-resistant cancers

The genetic mutation that causes sickle cell anemia also turns red blood cells into potent tumor killers and may offer a new way to treat cancers that are resistant to existing treatments, according to research published January 9, 2013 in the open access journal PLOS ONE by David S. Terman of Jenomic Research Institute and colleagues from Duke University and other institutions.

10 Jan 2013

MSF, DNDi analysis shows increased investment in NTDs but low number of new therapy approvals

"Over the past decade, neglected diseases have attracted increased attention and larger investments in research," but "a new analysis by Medecins Sans Frontieres (MSF) and the Drugs for Neglected Diseases Initiative (DNDi) finds that the rate of approvals for new compounds over the past decade is roughly the same as it was during the previous two-and-a-half decades, when the diseases received little attention," Nature Medicine reports.

10 Jan 2013

Fingolimod could potentially eliminate or reduce progression of colitis-associated cancer

After uncovering a mechanism that promotes chronic intestinal inflammation and the development of colorectal cancer, scientists from Virginia Commonwealth University Massey Cancer Center have found that fingolimod, a drug currently approved for the treatment of multiple sclerosis, could potentially eliminate or reduce the progression of colitis-associated cancer (CAC).

10 Jan 2013

Pharmaceutical News

CHOP to study antibiotic delivery to children after hospitalization for serious bacterial infection

Experimental vaccine elicits antibodies that can protect against Ebola virus infection

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Pfizer’s Quillivant XR now available in the U.S. for treatment of ADHD

Diospyrin inactivates a drug target for tuberculosis in new way

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Children with chronic medical conditions more likely to use alternative medicine

Multidisciplinary team work on proactive approach to flu vaccine design

Additional insights into workings of ALVAC vaccine against HIV

Fiscal cliff boosts clinical data registries, but cuts some health care payments

UCSF teams to study new ways to reduce childhood mortality and disease in developing nations

Melanomas that develop resistance to vemurafenib also become addicted to the drug

Cholera could be contained in Haiti by vaccinating less than half the population

FDA requires sleep drugs that contain zolpidem to lower recommended doses

New guidelines to help fast track radiation oncology drug development

Patients at high-risk for recurrent C. difficile with unnecessary antibiotic use

LM11A-31 effective at improving limb movement after spinal cord injury in mice

Mutation that causes sickle cell anemia may offer new way to treat drug-resistant cancers

MSF, DNDi analysis shows increased investment in NTDs but low number of new therapy approvals

Fingolimod could potentially eliminate or reduce progression of colitis-associated cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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