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Scientists identify new antibiotic substances in Russian Brown frog's skin

Following up on an ancient Russian way of keeping milk from going sour - by putting a frog in the bucket of milk - scientists have identified a wealth of new antibiotic substances in the skin of the Russian Brown frog. The study appears in ACS' Journal of Proteome Research.

13 Dec 2012

Doctors should use different therapies when treating older and younger patients with CLL

Doctors should use different therapies when treating older and younger patients with chronic lymphocytic leukemia, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James).

13 Dec 2012

New way to effectively make designer drugs that hit collections of protein targets simultaneously

An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.

13 Dec 2012

Opioids already in the body can enhance malignant tendencies of human cancer cells

A study led by University of Chicago researcher Patrick A. Singleton, Ph.D. and published in the journal Anesthesiology has shown that, even without the addition of further opioids such as morphine, opioids already in the body can enhance the malignant tendencies of human cancer cells.

13 Dec 2012

Heartbeat Experts announces increased revenue and expanded clients in emerging markets

Heartbeat Experts, the global leader in stakeholder management solutions for the life sciences industry, announced today increased revenue and expanded clients across Brazil, Russia, China, India and Korea. Heartbeat Experts' reported combined revenue from these markets grew 50% in the third quarter of 2012.

13 Dec 2012

GM604 target regulates over 4,000 genes: Genervon

Genervon scientists have confirmed that the target of GM604 regulates over 4,000 genes. More significantly, it modifies ALS disease progression by modulating at least 30 significant ALS related genes. It does this through at least 8 pathways, potentially more, and up to 22 biological processes.

13 Dec 2012

TSEC strategy can benefit postmenopausal women

Investigators at Wake Forest Baptist Medical Center have concluded research on a new postmenopausal hormone therapy that shows promise as an effective treatment for menopausal symptoms and the prevention of osteoporosis without increasing the risk for heart disease or breast cancer.

13 Dec 2012

Responsible Opioid Prescribing eBook from FSMB Foundation

The Federation of State Medical Boards (FSMB) Foundation announced today its publication of an eBook edition of "Responsible Opioid Prescribing: A Clinician's Guide" for Kindles, Nooks, iPads and other popular platforms.

13 Dec 2012

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

Takeda Global Research & Development Center, Inc., (Takeda) and H. Lundbeck A/S (Lundbeck) jointly announced today that the U.S. Food and Drug Administration (FDA) has accepted for filing their submission of a New Drug Application (NDA) for vortioxetine for the treatment of major depressive disorder (MDD) in adult patients.

13 Dec 2012

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for treatment because these patients are highly responsive to ALK-specific kinase inhibitors such as crizotinib.

From NanoString Technologies 13 Dec 2012

Viewpoints: Pelosi says higher Medicare age 'doesn't work;' Marketplace's clout could lower seniors' drug costs

In the talks to avert the fiscal cliff, the idea of raising the Medicare age is central to the Republican proposal. There's just one critical problem: It doesn't work. It doesn't have public support. It's unfair. And it doesn't lower health expenditures. Such a proposal is a reflection of the broader Republican plan: an assault on the middle class, seniors -- and our future.

12 Dec 2012

TKI-resistant human leukemia stem cells are the source of genomic instability

An international team of scientists, led by researchers from Temple University School of Medicine, has found that a source of mounting genomic chaos, or instability, common to chronic myeloid leukemia (CML) may lie in a pool of leukemia stem cells that are immune to treatment with potent targeted anticancer drugs.

12 Dec 2012

Review describes current state of lung cancer care

A review in the December issue of the journal Archives of Pathology & Laboratory Medicine by Paul Bunn Jr, MD, University of Colorado Cancer Center investigator and past president of ASCO, IASLC and AACI describes the current state of lung cancer care.

12 Dec 2012

FDA grants Orphan Drug designation to Milo Biotechnology's AAV1-FS344 inhibitor

Milo Biotechnology today announced its AAV1-FS344 has been granted Orphan Drug designation from the FDA's Office of Orphan Products Development for treatment of Becker and Duchenne muscular dystrophy. AAV1-FS344 is a gene therapy-delivered myostatin inhibitor that increases muscle strength.

12 Dec 2012

Drugs that bind to specific serotonin receptors can improve and impair female sexual function

Drugs that bind to specific serotonin receptors in the brain can both improve and impair female sexual function in non-human primates.

12 Dec 2012

Industry sponsored clinical trials present a more favourable picture of reported findings

Studies reporting the results of industry sponsored clinical trials present a more favourable picture of the effects of drugs and medical devices than those reporting on non-industry sponsored trials, according to a new Cochrane systematic review. The researchers call for a rethink of the way that industry bias is handled in medical guidelines and reviews.

12 Dec 2012

New collaborative model for drug discovery can ensure antibiotics are not lost to resistance

Noting "multidrug-resistant organisms are showing up in top-flight hospitals" around the world, Carl Nathan, chair of the department of microbiology and immunology at Weill Cornell Medical College, writes in this New York Times opinion piece, "What makes the rapid loss of antibiotics to drug resistance particularly alarming is that we are failing to make new ones."

12 Dec 2012

Low prices for life-saving products may increase perception of risk among consumers

Consumers assume their risk of getting a serious illness is higher when medications are cheaper because they believe that prices for life-saving products are based on need and not profit, according to a new study in the Journal of Consumer Research.

12 Dec 2012

Blocking myeloid-derived suppressor cells after lymphopenia improves adoptive T-cell therapy

Researchers at the Moffitt Cancer Center have found that delayed tumor growth and enhanced survival of mice bearing melanoma were possible by blocking the reconstitution of myeloid-derived suppressor cells and Tregs (suppressors of anti-tumor activity) after total body irradiation had eliminated them. Blocking myeloid-derived suppressor cells and regulatory T-cell reconstitution improved adoptive T-cell therapy, an immunotherapy designed to suppress tumor activity.

12 Dec 2012

Drugs for Neglected Diseases receives UNITAID grant for paediatric HIV programme

The Drugs for Neglected Diseases initiative welcomes the announcement by UNITAID to grant up to USD 17.3 million to the organization for its paediatric HIV programme.

12 Dec 2012

Pharmaceutical News

Scientists identify new antibiotic substances in Russian Brown frog's skin

Doctors should use different therapies when treating older and younger patients with CLL

New way to effectively make designer drugs that hit collections of protein targets simultaneously

Opioids already in the body can enhance malignant tendencies of human cancer cells

Heartbeat Experts announces increased revenue and expanded clients in emerging markets

GM604 target regulates over 4,000 genes: Genervon

TSEC strategy can benefit postmenopausal women

Responsible Opioid Prescribing eBook from FSMB Foundation

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

Viewpoints: Pelosi says higher Medicare age 'doesn't work;' Marketplace's clout could lower seniors' drug costs

TKI-resistant human leukemia stem cells are the source of genomic instability

Review describes current state of lung cancer care

FDA grants Orphan Drug designation to Milo Biotechnology's AAV1-FS344 inhibitor

Drugs that bind to specific serotonin receptors can improve and impair female sexual function

Industry sponsored clinical trials present a more favourable picture of reported findings

New collaborative model for drug discovery can ensure antibiotics are not lost to resistance

Low prices for life-saving products may increase perception of risk among consumers

Blocking myeloid-derived suppressor cells after lymphopenia improves adoptive T-cell therapy

Drugs for Neglected Diseases receives UNITAID grant for paediatric HIV programme

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

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