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Magnetic nanochain detonates chemo barrage inside tumors

Medicine-toting nanochains slip into tumors and explode a chemotherapy drug into hard-to-reach cores of cancer, engineers and scientists at Case Western Reserve University report.

19 Apr 2012

Researchers, advocates meet in Sydney to discuss state of microbicide, HIV prevention research

"Three decades after the full onset of the global HIV tragedy, science appears to finally be developing preventative measures, including microbicides that would thwart infections in the first place, according to individuals at" the biennial International Microbicides Conference in Sydney, the Asia Sentinel writes.

19 Apr 2012

New passive vaccine reverses dangerous symptoms of cocaine overdose

Scientists are reporting development and successful testing in laboratory mice of a substance that shows promise for becoming the first antidote for cocaine toxicity in humans. According to a report in ACS' journal Molecular Pharmaceutics, the new so-called "passive vaccine" reversed the motor impairment, seizures and other dangerous symptoms of a cocaine overdose, which claims thousands of lives each year among users of the illicit drug.

19 Apr 2012

Supreme Court rules generic drug makers can challenge branded drug companies' wording in patent applications

The U.S. Supreme Court handed a victory to generic-drug companies Tuesday, ruling they can file certain legal counterclaims against brand-drug companies in an effort to get their cheaper copycat medicines on the market. The court, in an opinion written by Justice Elena Kagan, ruled unanimously that generic-drug makers should be allowed to challenge the way brand-name manufacturers describe their patents to the Food and Drug Administration.

19 Apr 2012

First specific antidote for cocaine toxicity

Scientists at The Scripps Research Institute have shown that an injectable solution can protect mice from an otherwise lethal overdose of cocaine. The findings could lead to human clinical trials of a treatment designed to reverse the effects of cocaine in case of emergency. Cocaine is involved in more than 400,000 emergency-room visits and about 5,000 overdose deaths each year in the United States.

19 Apr 2012

Half of young adult tobacco smokers also have used marijuana in the last 30 days

Half of young adult tobacco smokers also have smoked marijuana in the last 30 days, according to a recent Facebook-based survey conducted by UCSF researchers, indicating a greater prevalence of marijuana and tobacco co-use among smokers age 18-25 than previously reported.

19 Apr 2012

GSK, Epizyme and Constellation to develop next generation of epigenetic drugs for cancer

Scientific insights that expand on the teachings of Mendel, Watson and Crick, and underpinnings of the Human Genome Project are moving drug companies along the path to development of new medicines based on deeper insights into how factors other than the genetic code influence health and disease. That's the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society (ACS), the world's largest scientific society.

19 Apr 2012

Ecstasy and speed-using grade ten students more likely to develop depression

A five year study conducted with thousands of local teenagers by University of Montreal researchers reveals that those who used speed (meth/ampthetamine) or ecstasy (MDMA) at fifteen or sixteen years of age were significantly more likely to suffer elevated depressive symptoms the following year. "Our findings are consistent with other human and animal studies that suggest long-term negative influences of synthetic drug use," said co-author Fr-d-ric N. Bri-re of the School Environment Research Group at the University of Montreal.

19 Apr 2012

Merck wins New Jersey FOSAMAX litigation

Merck, known outside the United States and Canada as MSD, today said a state court jury in New Jersey found in its favor in the Sessner v. Merck case, rejecting the claims of a woman who blamed her jaw-related problems on her FOSAMAX use.

19 Apr 2012

Link between hypertension drug adherence and total costs of care

Although adherence to hypertension medications was significantly associated with lower hospitalization rates, the total costs of care are higher for adherent patients than for patients who were deemed "non-adherent," according to a new study from pharmacy benefit manager Prime Therapeutics that will be presented this week at the Academy of Managed Care Pharmacy (AMCP)'s 24th Annual Meeting & Expo in San Francisco.

19 Apr 2012

Cruciferous vegetables protect and improve breast cellular health

Broccoli, cabbage, leafy greens, cauliflower-your mother insisted they were good for you while you defiantly pushed them around your plate. Perhaps you didn't believe they were all that good for you. If they're so great, why don't they taste better? Turns out your mother was right. These cruciferous vegetables have a profound influence on the health of your body's cells. In fact, a recent study by Vanderbilt University's Ingram Center showed that a diet full of cruciferous vegetables protects and improves breast cellular health.

19 Apr 2012

1 in 5 Australians expect antibiotics for coughs and colds: New NPS campaign

The survey also revealed a plethora of misconceptions when it comes to antibiotics with only half of respondents knowing that bacteria are becoming resistant to antibiotics. Only 40% knew antibiotics should not be taken for viruses and many (40%) did not know that taking antibiotics when they’re not needed contributes to antibiotic resistance. More than half did not know resistance increases when you don’t complete the course as directed and in general, the youth audience had less knowledge.

18 Apr 2012

USP convenes pharmaceutical supply chain integrity workshop

The increasing globalization of the drug supply presents a host of public health challenges: theft and diversion of medicines, growth of illegal Internet pharmacies and insertion of adulterated medicines or ingredients into the supply chain.

18 Apr 2012

Levodopa-carbidopa intestinal gel better than standard oral form to treat advanced Parkinson's disease

A levodopa-carbidopa intestinal gel (LCIG) works better than standard oral levodopa-carbidopa in reducing "off" time in patients with advanced Parkinson's disease.

18 Apr 2012

Early intervention of biologic therapies improves outcome for Crohn's disease

A large-scale study of medical claims data shows that introducing sophisticated biologic therapies early in the course of treatment for Crohn's disease improves response to medication and reduces the need for surgery.

18 Apr 2012

NSCLC drug regimen approved in 2006 does not improve survival for older patients

Analysis of a drug regimen approved by the F.D.A. in 2006 for the treatment of non-small cell lung cancer (bevacizumab added to the standard chemotherapy regimen carboplatin and paclitaxel) finds Medicare insured patients age 65 years and older who received this regimen did not have improved survival compared to patients who received the standard treatment of carboplatin and paclitaxel alone, according to a study in the April 18 issue of JAMA.

18 Apr 2012

Bevacizumab added to chemotherapy for NSCLC does not improve survival in elderly patients

Adding the drug bevacizumab (Avastin) to the standard chemotherapy regimen for non-small cell lung cancer (NSCLC) - an approach approved by the FDA in 2006 - did not lead to significantly increase survival rates for patients over the age of 65 enrolled in Medicare, a new study by Dana-Farber Cancer Institute researchers has found.

18 Apr 2012

Study supports tolerability of low-dose aripiprazole as an antidepressant therapy-augmenting agent

In the current issue of Psychotherapy and Psychosomatics there is a negative study on the use of aripiprazole in depression.

18 Apr 2012

Fibrates to treat high cholesterol may affect kidney health

Older patients taking a common cholesterol medication should be cautious of the impact on their kidney health. In a new study by Dr. Amit Garg, Scientist at the Lawson Health Research Institute and the Institute for Clinical Evaluative Sciences (ICES), and colleagues, one in 10 new older fibrate users experienced a 50 per cent increase in their serum creatinine.

18 Apr 2012

Allied Healthcare announces Coridon license to vector technology

Allied Healthcare Group (ASX: AHZ) has announced an update on the progress of Coridon, its investment company founded by Professor Ian Frazer and working on developing the next generation of vaccines. Included in these activities, Cordon has entered into a license agreement with Nature Technology Corporation (NTC) and has contracted VGXI Inc. in the US for production of clinical material for the Phase I study scheduled to begin later this year.

17 Apr 2012

Pharmaceutical News

Magnetic nanochain detonates chemo barrage inside tumors

Researchers, advocates meet in Sydney to discuss state of microbicide, HIV prevention research

New passive vaccine reverses dangerous symptoms of cocaine overdose

Supreme Court rules generic drug makers can challenge branded drug companies' wording in patent applications

First specific antidote for cocaine toxicity

Half of young adult tobacco smokers also have used marijuana in the last 30 days

GSK, Epizyme and Constellation to develop next generation of epigenetic drugs for cancer

Ecstasy and speed-using grade ten students more likely to develop depression

Merck wins New Jersey FOSAMAX litigation

Link between hypertension drug adherence and total costs of care

Cruciferous vegetables protect and improve breast cellular health

1 in 5 Australians expect antibiotics for coughs and colds: New NPS campaign

USP convenes pharmaceutical supply chain integrity workshop

Levodopa-carbidopa intestinal gel better than standard oral form to treat advanced Parkinson's disease

Early intervention of biologic therapies improves outcome for Crohn's disease

NSCLC drug regimen approved in 2006 does not improve survival for older patients

Bevacizumab added to chemotherapy for NSCLC does not improve survival in elderly patients

Study supports tolerability of low-dose aripiprazole as an antidepressant therapy-augmenting agent

Fibrates to treat high cholesterol may affect kidney health

Allied Healthcare announces Coridon license to vector technology

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

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