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Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis

For nearly 60 years, Pyrazinamide (PZA) has been used in conjunction with other medications to treat tuberculosis (TB), but scientists did not fully understand how the drug killed TB bacteria. PZA plays a unique role in shortening the duration of current TB therapy to six months and is used frequently to treat multi-drug resistant TB.

12 Aug 2011

Mylan introduces generic version of Uroxatral for benign prostatic hyperplasia

Mylan Inc. today announced that its subsidiary Mylan Pharmaceuticals Inc. has shipped Alfuzosin Hydrochloride Extended-release Tablets, 10 mg.

12 Aug 2011

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia.

12 Aug 2011

NSAIDs like ibuprofen slow the spread of breast cancers

Published online on Aug. 7, 2011, the journal Nature Medicine reports that non-steroidal anti-inflammatory drugs including ibuprofen reduce the severity of postpartum breast cancers in animal models.

12 Aug 2011

Endothelial progenitor cells may repair leaky blood-brain barrier

University of South Florida Department of Neurosurgery and Brain Repair faculty members have received a $2.6 million grant from the National Institutes of Health to investigate the potential for cells derived from human bone marrow to benefit post-stroke patients by repairing the blood-brain barrier.

12 Aug 2011

Pregnant women lack enough vitamin D despite use of prenatal supplements

Pregnant women taking prenatal supplements may not be getting enough vitamin D, shows a new Vancouver-based study led by the Child & Family Research Institute at BC Children's Hospital that was published in the Canadian Journal of Public Health.

12 Aug 2011

Researchers discover key reason why pyrazinamide shortens duration of TB therapy

Pyrazinamide has been used in combination with other drugs as a first-line treatment for people with tuberculosis (TB) since the 1950s, but exactly how the drug works has not been well understood.

12 Aug 2011

FDA assigns PDUFA action date for review of Affymax peginesatide NDA

Affymax, Inc. today announced that the U.S. Food and Drug Administration has assigned a Prescription Drug User Fee Act (PDUFA) action date of March 27, 2012 for the review of the investigational agent peginesatide New Drug Application.

12 Aug 2011

Nephros submits new 510(k) application with FDA for clearance of hemodiafiltration system

Nephros, Inc., a medical device company developing and marketing filtration products for therapeutic applications, infection control, and water purification, today announced that on August 11, 2011 it filed a 510(k) application with the Food and Drug Administration (FDA) for clearance of its hemodiafiltration system.

12 Aug 2011

Anticoagulation service improves quality of care for patients treated with warfarin

A pharmacist-directed anticoagulation service improves the coordination of care from the hospital to an outpatient clinic for patients treated with the anticoagulant drug warfarin, according to a Henry Ford Hospital study.

11 Aug 2011

Higher protein intake helps postmenopausal obese women lose more weight

Dieting postmenopausal women who want to avoid losing muscle as they lose fat should pay attention to a new University of Illinois study. Adding protein throughout the day not only holds hunger pangs at bay so that dieters lose more weight, it keeps body composition-the amount of fat relative to muscle-in better proportion.

11 Aug 2011

PUFA intake linked to reduced risk of heart failure, kidney disease and preterm delivery

Omega-3 polyunsaturated fats (PUFAs) found in seafood may reduce arterial stiffness and improve heart function in chronic heart failure, according to new research. These fats, better known as EPA and DHA, may also help in the immediate aftermath of a stroke.

11 Aug 2011

BCG vaccine can help immune system recognise cancer cells as 'foreign'

Scientists have found a potential new mechanism to stimulate the body's own ability to fight cancer using Baculillus Calmette-Guerin (BCG) - the germ commonly used to inoculate against tuberculosis.

11 Aug 2011

Merck receives Oliver Wight Class A certification

Pharmaceutical and chemical giant Merck KGaA has been awarded Class A certification by Oliver Wight after dramatic improvements in service levels and a €15 million reduction in inventory, at its Darmstadt pharmaceutical production facility.

11 Aug 2011

Pharma IQ to launch Compound Management and Integrity Online event

Pharma IQ is pioneering new compound management discussion platform with launch of the first ever compound management event - Compound Management and Integrity Online event, which will take an innovative form of 11 online session over the course of 5 weeks, beginning 31st of October 2011.

11 Aug 2011