Rotavirus vaccine saved 65,000 hospitalizations and $278 million in healthcare costs: Study

The latest research shows that since the 2006 introduction of routine inoculation against rotavirus -- a leading cause of diarrhea in infants and young children -- almost 65,000 fewer American children have been hospitalized and about $278 million in healthcare costs have been saved.

The vaccine prevents rotavirus infection which is a common and easily transmitted pathogen. The new study, from a team at the U.S. Centers for Disease Control and Prevention (CDC), found that there were 89 percent fewer rotavirus-specific hospitalizations in children who had gotten the vaccine compared to unvaccinated children.

Study’s senior author, Dr. Umesh Parashar, a medical epidemiologist and team leader of the viral gastroenteritis team at the CDC in Atlanta said, “Diarrhea caused by rotavirus is one of the most common illnesses in children. It's usually self-limited and treated at home, but before the vaccine was introduced, the virus was responsible for about 200,000 emergency room visits and 400,000 physician office visits a year.”

Before 2006 vaccinations the virus was associated with 20 to 60 deaths a year in children under 5 in the United States - although that figure was much higher in developing countries. “In the U.S., with good access to healthcare, we can prevent the worse outcomes from diarrheal illness. Globally, there are about a half a million deaths caused by this pathogen,” Parashar added. Results of the study are published in the Sept. 22 issue of the New England Journal of Medicine.

Rotavirus vaccine was first available in 1998. However, it was quickly withdrawn from the market when otherwise healthy babies began to develop a condition known as intussusception. This condition causes the bowel to fold into itself, much like a telescope, triggering an often life-threatening bowel obstruction. The vaccine was withdrawn from the market in 1999, when the CDC linked these cases with the administration of the vaccine. The CDC estimated that for every 10,000 doses of vaccine, about one to two cases of intussusceptions occurred.

However, rotavirus itself is a risk factor for developing intussusception, according to information from the CDC, and to infectious disease specialist, Dr. Marian Michaels, from Children's Hospital of Pittsburgh, Penn.

Michaels said that before the current, safer versions of the rotavirus vaccine came to market, studies including tens of thousands of children were done. “This was really something people took very seriously. They wanted to make sure that we first cause no harm,” she said. So, since 2006, two new versions of rotavirus vaccine have been introduced.

Parashar said the current study didn't look at rates of intussusception, but research in Latin America and Australia has found that the incidence there was approximately one or two per 100,000 babies vaccinated. The study estimated that if this finding applied to the United States and all infants in the country were vaccinated, there would be an additional 50 cases of intussusception and additional health care costs of about $500,000, in contrast to the tens of thousands of hospitalizations prevented and millions of dollars saved by vaccinating against rotavirus. “The most important thing is that this vaccine decreases the risk of a child getting rotavirus, and possibly needing hospitalization because of dehydration. The benefits of this vaccine outweigh the risks,” said Michaels.

Parashar and his colleagues compared 2007-2009 data from U.S. insurance databases against similar data from 2001 through 2006, to assess trends in rotavirus hospitalizations, ER visits and physician-office visits over time. By the end of 2008, 73 percent of children had gotten at least one dose of rotavirus vaccine, 64 percent of children between one and two years of age had at least the initial dose of the vaccine, and 8 percent of children between two and four years old had at least one dose. Parashar said the vaccine needs to be given before children are eight months old.

The researchers found that hospitalization rates for diarrhea went down as much as 33 percent after introduction of the vaccine. For rotavirus-specific hospitalizations, the rate went down as much as 75 percent, according to the study. When the researchers compared vaccinated and unvaccinated children, they found the rate of rotavirus-specific hospitalizations were 89 percent less for vaccinated children. The number of ER visits were about 48 percent lower for vaccinated children, and physician office visits were around 12 percent lower for children who received the vaccine.

Greg Yapalater, a New York City pediatrician in private practice, is not ready to endorse the rotavirus vaccine, yet. “With any new vaccine, I need to see a good safety profile and there are still some cases of intussusception,” he said. “I am concerned.” He is taking a watch-and-wait approach before recommending that infants receive the rotavirus vaccine. “I don't vaccinate against something that could cause dehydration if there is a chance the vaccine could cause a condition that is life-threatening,” he says. “I love the concept of the vaccine, but need to see a better safety profile.”

Parashar concluded, “Rotavirus is the most common cause of severe diarrheal illness. The vaccine can prevent and reduce the disease burden substantially.” “

The CDC recommends that infants get vaccinated for rotavirus. There are two available rotavirus vaccines. The RotaTeq vaccine is given in three doses at ages 2 months, 4 months, and 6 months. The Rotarix vaccine is given as two doses at 2 months and 4 months.

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2018, August 23). Rotavirus vaccine saved 65,000 hospitalizations and $278 million in healthcare costs: Study. News-Medical. Retrieved on August 06, 2020 from https://www.news-medical.net/news/20110926/Rotavirus-vaccine-saved-65000-hospitalizations-and-24278-million-in-healthcare-costs-Study.aspx.

  • MLA

    Mandal, Ananya. "Rotavirus vaccine saved 65,000 hospitalizations and $278 million in healthcare costs: Study". News-Medical. 06 August 2020. <https://www.news-medical.net/news/20110926/Rotavirus-vaccine-saved-65000-hospitalizations-and-24278-million-in-healthcare-costs-Study.aspx>.

  • Chicago

    Mandal, Ananya. "Rotavirus vaccine saved 65,000 hospitalizations and $278 million in healthcare costs: Study". News-Medical. https://www.news-medical.net/news/20110926/Rotavirus-vaccine-saved-65000-hospitalizations-and-24278-million-in-healthcare-costs-Study.aspx. (accessed August 06, 2020).

  • Harvard

    Mandal, Ananya. 2018. Rotavirus vaccine saved 65,000 hospitalizations and $278 million in healthcare costs: Study. News-Medical, viewed 06 August 2020, https://www.news-medical.net/news/20110926/Rotavirus-vaccine-saved-65000-hospitalizations-and-24278-million-in-healthcare-costs-Study.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
You might also like... ×
GAMA Healthcare adds four new hires to its expanding Science and Innovation team