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Mcl-1 inhibition blocks cell survival in ER+ breast cancers

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

26 Nov 2019

Splicing factor enhances ability of triple negative breast cancers to grow and metastasize

If your DNA is a cookbook, a single gene is a recipe. But it's a flexible recipe that if edited one way can make a pie; edited another way can make a cake. And that difference can mean cancer, as a team of researchers who looked at those gene editors writes in the 26 November issue of Cell Reports.

26 Nov 2019

California’s working mothers get stronger support for workplace lactation

Katie Woody's firstborn, Oliver, struggled from birth to latch onto her breast, so she had little choice but to pump her milk and feed it to him from a bottle.

26 Nov 2019

Opioid use during pregnancy alters the baby's brain

During pregnancy, everything taken in by the mother crosses the placenta. Opioid use during pregnancy is tied to changes in the baby’s brain, a new study found.

25 Nov 2019

Women may be preferentially underdiagnosed for obstructive sleep apnea

Obstructive sleep apnea (OSA) has been considered a predominantly male disease. While more women have been diagnosed with OSA in recent years, the numbers remain disproportionate, with 3-to-5 times more men than women receiving an OSA diagnosis.

25 Nov 2019

HIV diagnosis falls to a record low in NYC, finds report

Reporting of new cases of HIV started in 2001 and since then there has been a steady rise and stability of numbers. In 2018 for the first time in nearly two decades, researchers have reported number of new cases to be below 2,000 over the year. This is a record 67 percent decline in the numbers since 2001, says the report. Further the decline in the numbers has been seen in nearly all age groups between 2017 and 2018.

25 Nov 2019

Women treated for early-stage breast cancer may develop invasive breast cancer

New research in the November 2019 issue of JNCCN—Journal of the National Comprehensive Cancer Network examines the implications of invasive breast cancer after breast-conserving treatment for ductal carcinoma in situ (aka DCIS, a form of non-invasive breast cancer) and which factors could impact overall survival.

25 Nov 2019

Nanotechnology could help address pre-eclampsia which affects 10 million women

University of South Australia biomedical engineer Dr. Marnie Winter has been awarded US$100,000 from the world's largest private foundation to help better understand and tackle a condition which kills 76,000 women and 500,000 babies each year.

25 Nov 2019

Environmental stress weakens women's ability to adapt to climate change

New research led by the University of East Anglia suggests that male migration and poor working conditions for women combine with institutional failure or poverty to hamper women's ability to adapt to climate variability and change in Asia and Africa.

25 Nov 2019

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

25 Nov 2019

Breast-conserving treatment may be a viable alternative to mastectomy, study suggests

Approximately 10% of breast cancer patients treated with lumpectomy (breast-conserving surgery [BCS]) and whole-breast radiation (WBI) will have a subsequent in-breast local recurrence of cancer (IBTR) when followed long term.

22 Nov 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019