Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Crealta to acquire all assets of Savient Pharmaceuticals

Savient Pharmaceuticals, Inc. ("Savient") announced that it has reached agreement on the terms of an acquisition agreement with Crealta Pharmaceuticals LLC ("Crealta") through which Crealta would acquire substantially all of the assets of Savient, including all KRYSTEXXA® assets, for gross proceeds of approximately $120.4 million.

11 Dec 2013

Experimental compound reduces joint inflammation in animal models of rheumatoid arthritis

An experimental compound synthesized and developed by scientists from the Florida campus of The Scripps Research Institute has the capacity to significantly reduce joint inflammation in animal models of rheumatoid arthritis, an autoimmune disease that affects more than two million Americans.

11 Dec 2013

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Bone homeostasis requires precise balance between deposition of new bone by osteoblasts and resorption of old bone by osteoclasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased osteoclast activity and formation, which allows bone resorption to outpace deposition.

9 Dec 2013

Two-armed approach to vascular risk prediction

People with different blood pressures in their left and right arms have an increased risk for cardiovascular events, even if they do not have hypertension, shows a population-based analysis.

9 Dec 2013

Janssen announces first-of-its-kind pediatric HIV treatment donation program

Janssen, the pharmaceutical companies of Johnson & Johnson, today announced a first-of-its-kind pediatric HIV treatment donation program to improve access to the company's approved HIV medicines for children and adolescents failing HIV treatment in sub-Saharan Africa.

9 Dec 2013

NYU Langone Medical Center researchers find link between gut bacteria and colorectal cancer

In one of the largest epidemiological studies of human gut bacteria and colorectal cancer ever conducted, a team of researchers at NYU Langone Medical Center has found a clear association between gut bacteria and colorectal cancer. The study, published today in the Journal of the National Cancer Institute, discovered that colorectal cancer patients had fewer beneficial bacteria and more harmful bacteria than people without the disease.

6 Dec 2013

Johns Hopkins researchers discover some cases of scleroderma likely to be initiated by cancer

The Scleroderma Research Foundation today reported that researchers at The Johns Hopkins University have discovered that some cases of scleroderma are likely to have been initiated by cancer.

6 Dec 2013

Scientists identify key factor for limiting inflammatory responses, particularly in skin

Sanford-Burnham scientists have identified the B and T Lymphocyte Attenuator (BTLA) inhibitory receptor as a key factor in limiting inflammatory responses, particularly in the skin. The study, published online today in Immunity, provides clarity on how T cells get fired up to protect against pathogens, and then cool down to restore immune homeostasis.

6 Dec 2013

Cancer triggers scleroderma, shows evidence

Johns Hopkins scientists have found evidence that cancer triggers the autoimmune disease scleroderma, which causes thickening and hardening of the skin and widespread organ damage.

6 Dec 2013

Manipulation of Wnt/B-catenin pathway provides therapeutic targets for hair loss, skin cancer

A pathway known for its role in regulating adult stem cells has been shown to be important for hair follicle proliferation, but contrary to previous studies, is not required within hair follicle stem cells for their survival, according to researchers with the Perelman School of Medicine at the University of Pennsylvania.

5 Dec 2013

CEL-SCI gets approval to start enrollment for Multikine Phase III study for head and neck cancer

Further advancing one of the largest Phase III trials for head and neck cancer in the world, CEL-SCI Corporation announced today that it has received approval from the Agency for Medicaments and Medical Devices of the government of Bosnia and Herzegovina to begin enrollment of subjects into the Phase III Head and Neck Cancer clinical trial of its investigational cancer immunotherapy treatment Multikine (Leukocyte Interleukin, Injection).

5 Dec 2013

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

The skeleton is constantly being remodelled by the breakdown of old bone by cells called osteoclasts and the formation of new bone by cells called osteoblasts. This coordinated activity is essential for maintaining healthy bone. However, excessive osteoclast activity leads to bone destruction in skeletal diseases such as osteoporosis, rheumatoid arthritis and cancer metastases in bone. A family of signaling enzymes known as phosphatidylinositol 3-kinases control diverse cell functions but, up until now, little was known about the function of specific PI3K isoforms in osteoclasts.

5 Dec 2013

IDSA released new guideline for vaccination of immunocompromised hosts

A new guideline released Thursday by the Infectious Diseases Society of America (IDSA) notes that most people with compromised immune systems are especially vulnerable to illness and should receive the flu shot and other vaccinations.

5 Dec 2013

CJR surgeons to perform free joint replacement surgeries on 17 patients

More than 2 million Americans suffer from debilitating hip, knee and joint conditions. Severe joint pain and arthritis can affect almost all aspects of an individual's life, often preventing them from working, enjoying the activities they love and performing simple, everyday tasks.

4 Dec 2013

Young athletes are more prone to hip impingement, say specialists

Hip pain is no longer reserved for older adults. More and more young, active people are developing this problem, which often requires surgery to repair.

4 Dec 2013

Patients with RA today have easier time with daily living than patients diagnosed two decades ago

New research reveals that patients with rheumatoid arthritis today have an easier time with daily living than patients diagnosed two decades ago. According to results of the study published in Arthritis Care & Research, a journal of the American College of Rheumatology, anxiety, depressed mood and physical disability have been cut in half over the last 20 years. Researchers believe a reduction in disease activity is partly responsible for this positive change.

3 Dec 2013

People who suffer with chronic pain face daily struggle with sense of self

People who suffer with chronic musculoskeletal pain face a daily struggle with their sense of self and find it difficult to prove the legitimacy of their condition.

3 Dec 2013

Researchers find evidence that gout clusters in families

It's historically known as 'the king of diseases and the disease of kings' and was long thought to be caused by an overindulgent lifestyle, but now scientists at The University of Nottingham have confirmed that 'gout' strongly runs in families.

3 Dec 2013

Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

A new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs.

3 Dec 2013

Hypertension organ risk revealed in Chinese patients

A study of Chinese patients warns of the risk for target organ damage from untreated hypertension, especially for younger patients.

2 Dec 2013

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Crealta to acquire all assets of Savient Pharmaceuticals

Experimental compound reduces joint inflammation in animal models of rheumatoid arthritis

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Two-armed approach to vascular risk prediction

Janssen announces first-of-its-kind pediatric HIV treatment donation program

NYU Langone Medical Center researchers find link between gut bacteria and colorectal cancer

Johns Hopkins researchers discover some cases of scleroderma likely to be initiated by cancer

Scientists identify key factor for limiting inflammatory responses, particularly in skin

Cancer triggers scleroderma, shows evidence

Manipulation of Wnt/B-catenin pathway provides therapeutic targets for hair loss, skin cancer

CEL-SCI gets approval to start enrollment for Multikine Phase III study for head and neck cancer

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

IDSA released new guideline for vaccination of immunocompromised hosts

CJR surgeons to perform free joint replacement surgeries on 17 patients

Young athletes are more prone to hip impingement, say specialists

Patients with RA today have easier time with daily living than patients diagnosed two decades ago

People who suffer with chronic pain face daily struggle with sense of self

Researchers find evidence that gout clusters in families

Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

Hypertension organ risk revealed in Chinese patients

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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