Chromosome News and Research

Latest Chromosome News and Research

Pollution exposure during pregnancy can cause chromosomal abnormalities in fetal tissues

A new study of newborns in New York City reveals that prenatal exposure to combustion-related urban air pollutants alters the structure of chromosomes (the carriers of genes) of babies in the womb.

23 Feb 2005

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome. Cells with the abnormal chromosome make a protein that encourages aberrant growth and division. Patients with CML can be treated with a drug called imatinib or interferon alfa.

20 Feb 2005

Separating chromosomes improves genetic test results

A new process that helps unmask genetic mutations by separating chromosomes so they can be studied individually may improve the diagnostic yield of some genetic tests, according to findings of a Colon Cancer Family Registry study published today in the Journal of the American Medical Association.

16 Feb 2005

Novel genetic test helps detect mutations that may be missed by conventional DNA test

Researchers have identified a genetic test that when used with DNA testing would detect a higher number of genetic mutations in colorectal cancer patients, according to a study in the February 16 issue of JAMA, a theme issue on medical applications of biotechnology.

15 Feb 2005

Angiogenesis inhibitor molecules defend against the development and spread of cancer

Research led by investigators at Beth Israel Deaconess Medical Center (BIDMC) helps explain how a group of angiogenesis inhibitor molecules serve as an important defense mechanism against the development and spread of cancer, offering key insights into why cancerous tumors grow at different rates among different individuals.

15 Feb 2005

Exposure of expectant mothers to urban air pollution may alter the structure of babies' chromosomes while in the womb

A new study of 60 newborns in New York City reveals that exposure of expectant mothers to combustion-related urban air pollution may alter the structure of babies' chromosomes while in the womb.

15 Feb 2005

New primate-specific gene family that spans about 10% of human chromosome 2

A team of scientists led by Peer Bork, Ph.D., Senior Bioinformatics Scientist at the European Molecular Biology Laboratory, report today in the journal Genome Research that they have identified a new primate-specific gene family that spans about 10% of human chromosome 2.

13 Feb 2005

Experimental drug Revlimid showing promise as treatment for myelodysplastic syndrome (MDS)

Alan List, M.D., leader of the Hematologic Malignancies Program at the H. Lee Moffitt Cancer Center & Research Institute, recently conducted a phase I/II trial of the experimental drug Revlimid showing promise as an innovative way to treat patients with myelodysplastic syndrome (MDS), a form of pre-leukemia.

10 Feb 2005

Level of immune cell DNA in the blood might help predict success of stem cell transplantation

Measuring the quantity of a certain type of immune cell DNA in the blood could help physicians predict whether a bone marrow stem cell transplant will successfully restore a population of infection-fighting cells called T lymphocytes in a child.

7 Feb 2005

Short girls with underlying disease are not being diagnosed

Twice as many boys as girls are referred to medical specialists for evaluation of short stature or poor growth, according to a new study.

7 Feb 2005

Gene used in brain development can cause childhood brain cancers

A gene that's normally silenced after contributing to brain development was found to be expressed in cells from medulloblastoma, the most common form of pediatric brain malignancy in children, scientists report in an article published in the February 1 issue of the journal Cancer Research.

3 Feb 2005

Do genes play a role in determining whether a man is gay or heterosexual?

In the first-ever study combing the entire human genome for genetic determinants of male sexual orientation, a University of Illinois at Chicago researcher has identified several areas that appear to influence whether a man is heterosexual or gay.

31 Jan 2005

Genetic defect leads to electrical instability and mechanical pump failure

In genetic mapping of a large family with several members affected by a type of heart failure called dilated cardiomyopathy (DCM), the Mayo Clinic team found a defect in a gene on chromosome 3 called SCN5A.

26 Jan 2005

High blood pressure risk in African-Americans linked to genetics

National health records have shown that African-Americans are more prone to high blood pressure than Caucasians, but pinning down the roots of that difference has proven elusive. Now, researchers at the Stanford University School of Medicine have narrowed down the search for genes that contribute to this difference in disease risk.

24 Jan 2005

Study provides insight into strategies for telomere-based molecular cancer therapeutics

A new study published in the January issue of Cancer Cell provides exciting new information about how to boost the effectiveness of a promising cancer treatment that targets telomeres in an attempt to interfere with the ability of a cancer cell to continuously divide.

17 Jan 2005

Missing sequence of the human Y chromosome may contain genes controlling stature and tumor development

Scientists have reported in the journal Genome Research that they have successfully cloned and characterized a previously intractable DNA sequence: a 554-kilobase-pair genomic segment near the centromere of the human Y chromosome. This sequence contains eight putatively active genes that could be implicated in sex-associated height differences and gonadal tumor development.

16 Jan 2005

Using models to understand malaria

Malaria is one of the world's major killers. More than 500 million people live in epidemic regions and some 2 million - mostly children - die each year. And each year, drug resistance increases in the malarial parasite, Plasmodium falciparum, and the search for new treatments becomes more desperate.

12 Jan 2005

Corticosteroids can be beneficial in the treatment of Duchenne muscular dystrophy

Corticosteroids can be beneficial in the treatment of Duchenne muscular dystrophy and can be offered as a treatment option, according to the American Academy of Neurology and the Child Neurology Society in a new practice guideline published in the January 11 issue of Neurology, the scientific journal of the American Academy of Neurology.

10 Jan 2005

Plant research may help understand cancer

The development of cancer is a complex process with a number of different causes. The root problem is loss of control in the cell division process. A fundamental biological process, cell division can be studied in many organisms.

10 Jan 2005

Novel Structure Proteins (NSP) could help predict the possibility of tumor growth in a patient

A new family of genes called Novel Structure Proteins (NSP) discovered by researchers in the Sbarro Institute for Cancer Research and Molecular Medicine in Temple University’s College of Science and Technology could have the potential for predicting the possibility of tumor growth in a patient.

9 Jan 2005

Chromosome News and Research

Latest Chromosome News and Research

Pollution exposure during pregnancy can cause chromosomal abnormalities in fetal tissues

Vaccine that boosts the immune response could improve the effect of conventional treatment for patients with chronic myeloid leukaemia

Separating chromosomes improves genetic test results

Novel genetic test helps detect mutations that may be missed by conventional DNA test

Angiogenesis inhibitor molecules defend against the development and spread of cancer

Exposure of expectant mothers to urban air pollution may alter the structure of babies' chromosomes while in the womb

New primate-specific gene family that spans about 10% of human chromosome 2

Experimental drug Revlimid showing promise as treatment for myelodysplastic syndrome (MDS)

Level of immune cell DNA in the blood might help predict success of stem cell transplantation

Short girls with underlying disease are not being diagnosed

Gene used in brain development can cause childhood brain cancers

Do genes play a role in determining whether a man is gay or heterosexual?

Genetic defect leads to electrical instability and mechanical pump failure

High blood pressure risk in African-Americans linked to genetics

Study provides insight into strategies for telomere-based molecular cancer therapeutics

Missing sequence of the human Y chromosome may contain genes controlling stature and tumor development

Using models to understand malaria

Corticosteroids can be beneficial in the treatment of Duchenne muscular dystrophy

Plant research may help understand cancer

Novel Structure Proteins (NSP) could help predict the possibility of tumor growth in a patient

This International Women’s Day, Meet the Scientist Changing Women’s Healthcare

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Chromosome News and Research

Latest Chromosome News and Research

This International Women’s Day, Meet the Scientist Changing Women’s Healthcare

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

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