Crohn's Disease

Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

What is Crohn's Disease?

Crohn’s disease is a disease that leads to severe inflammation of the lining of the digestive system.

Crohn's Disease Cause

History of Crohn's Disease

Crohn's Disease Symptoms

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

Intestinal Mycoplasma and Crohn's Disease

Latest Crohn's Disease News and Research

Research uncovers alternative inflammatory pathway in rheumatoid arthritis treatment

The class of anti-inflammatory drugs known as TNF-inhibitors has brought relief to many sufferers of rheumatoid arthritis, but they don't work for up to 4 of every 10 patients.

30 Jan 2026

Discovery explains why people with IBD have higher risk of colorectal cancer

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone marrow—may help explain why people with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer, according to a preclinical study by Weill Cornell Medicine investigators.

22 Jan 2026

Pregnant individuals with inflammatory bowel disease show heightened vaginal inflammation

Pregnant individuals with inflammatory bowel disease (IBD) have higher levels of pro-inflammatory immune molecules, known as cytokines, in their vaginal mucosa than their healthy counterparts, according to a new study published January 14, 2026 in the open-access journal PLOS One by Ana Maldonado-Contreras of University of Massachusetts Chan Medical School, U.S., and colleagues.

14 Jan 2026

Short-term, calorie-restrictive diet improves Crohn’s disease symptoms

A Stanford Medicine-led study finds a short-term, calorie-restrictive diet significantly improved symptoms.

13 Jan 2026

Blood test opens the doors to early diagnosis and prevention of Crohn's disease

Sinai Health researchers have shown a blood test that can predict Crohn's disease years before symptoms appear, opening the doors to early diagnosis and potentially prevention.

12 Jan 2026

Research points to major healthcare access challenges faced by young adults with IBD

The Crohn's & Colitis Foundation today revealed compelling new research pointing to major healthcare access challenges and financial burdens disproportionately affecting young adults with Inflammatory Bowel Disease (IBD).

6 Jan 2026

Study demonstrates significant changes in gut bacteria at the onset of IBD

Patients experience significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a new international study has found - offering new hope for earlier diagnosis and future treatments.

23 Dec 2025

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

This narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.

11 Dec 2025

Toxin-secreting gut bacterium emerges as a driver of ulcerative colitis

A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study. The findings suggest potential for new treatment strategies.

20 Nov 2025

AGA issues updated guidance for pharmacologic treatment of moderate-to-severe Crohn's disease

The American Gastroenterological Association (AGA) has released a comprehensively updated clinical guideline on the pharmacological management of moderate-to-severe Crohn's disease.

20 Nov 2025

Study links common Epstein-Barr virus to autoimmune lupus

One of humanity's most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus or, colloquially, lupus, Stanford Medicine investigators and their colleagues have found.

12 Nov 2025

New method brings hope for personalized treatment of inflammatory bowel disease

Patients with inflammatory bowel disease often have to wait a long time to find the right medicine. But the methods of a large interdisciplinary research team offer hope.

5 Nov 2025

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Study reveals that group B [FeFe]-hydrogenase is the primary enzyme driving fermentative hydrogen production in the healthy human gut, mainly through Bacteroides species. These genes are significantly depleted in Crohn’s disease, indicating a metabolic shift and altered hydrogen cycling dominated by respiratory bacteria

27 Oct 2025

Hydrogen plays a bigger role in gut function than previously thought

Farts are causing a stink in the research world, but in a positive way.

23 Oct 2025

UCLA scientists uncover the role of DGRs in structuring the infant gut microbiome

Everywhere you go, you carry a population of microbes in your gastrointestinal tract that outnumber the human cells making up your body.

10 Oct 2025

AI serves as a tool to fight drug resistance and accelerate new antibiotic development

Researchers at McMaster University and the Massachusetts Institute of Technology (MIT) have made two scientific breakthroughs at once: they not only discovered a brand-new antibiotic that targets inflammatory bowel diseases (IBD), but also successfully used a new type of AI to predict exactly how the drug works. To their knowledge, this a global first for the AI.

3 Oct 2025

Pioneering initiative launched to connect data from IBD registries around the world

The Crohn's & Colitis Foundation and an international consortium of leading IBD researchers, today announced the launch of the Global IBD Registry (GLIDE), a pioneering initiative designed to securely connect data from inflammatory bowel disease (IBD) registries around the world.

23 Sep 2025

Early diagnosis and modern therapies improve Crohn’s disease prognosis

Crohn's disease, a type of inflammatory bowel disease (IBD), impacts millions worldwide. The disease is chronic and highly unpredictable, manifesting symptoms such as abdominal pain, diarrhea — sometimes with blood — and severe fatigue.

13 Sep 2025

Mushrooms deliver nutrition medicine and sustainability solutions in one package

This Food Science & Nutrition review highlights mushrooms as nutrient-rich functional foods packed with bioactive compounds that support human health. It explores their therapeutic, industrial, and environmental applications, from disease prevention and drug discovery to bioremediation and bioenergy.

8 Sep 2025

New insights into pathogenic T cells offer hope for Crohn's disease treatment

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

4 Sep 2025

Crohn's Disease

Overview

Crohn's Disease Cause

History of Crohn's Disease

Crohn's Disease Symptoms

Feature Articles

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

Intestinal Mycoplasma and Crohn's Disease

Latest Crohn's Disease News and Research

Research uncovers alternative inflammatory pathway in rheumatoid arthritis treatment

Discovery explains why people with IBD have higher risk of colorectal cancer

Pregnant individuals with inflammatory bowel disease show heightened vaginal inflammation

Short-term, calorie-restrictive diet improves Crohn’s disease symptoms

Blood test opens the doors to early diagnosis and prevention of Crohn's disease

Research points to major healthcare access challenges faced by young adults with IBD

Study demonstrates significant changes in gut bacteria at the onset of IBD

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

Toxin-secreting gut bacterium emerges as a driver of ulcerative colitis

AGA issues updated guidance for pharmacologic treatment of moderate-to-severe Crohn's disease

Study links common Epstein-Barr virus to autoimmune lupus

New method brings hope for personalized treatment of inflammatory bowel disease

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Hydrogen plays a bigger role in gut function than previously thought

UCLA scientists uncover the role of DGRs in structuring the infant gut microbiome

AI serves as a tool to fight drug resistance and accelerate new antibiotic development

Pioneering initiative launched to connect data from IBD registries around the world

Early diagnosis and modern therapies improve Crohn’s disease prognosis

Mushrooms deliver nutrition medicine and sustainability solutions in one package

New insights into pathogenic T cells offer hope for Crohn's disease treatment

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

Crohn's Disease

Overview

Feature Articles

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

Intestinal Mycoplasma and Crohn's Disease

Latest Crohn's Disease News and Research

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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