Dopamine News and Research

Latest Dopamine News and Research

Merck Serono starts second phase III trial of Safinamide in advanced Parkinson's

Merck Serono announced today the initiation of the SETTLE study. This study will evaluate the efficacy and safety of a dose range of safinamide (50-100 mg once daily) as add-on therapy to a stable dose of levodopa, in mid- to late-stage Parkinson's disease patients with motor fluctuations compared to placebo.

7 May 2009

Potential molecular target for new schizophrenia treatments

A study on schizophrenia has implicated machinery that maintains the flow of potassium in cells and revealed a potential molecular target for new treatments. Expression of a previously unknown form of a key such potassium channel was found to be 2.5 fold higher than normal in the brain memory hub of people with the chronic mental illness and linked to a hotspot of genetic variation.

5 May 2009

oct3 protein key to Parkinson's, drug addiction

Scientists have identified a protein that appears not only to be central to the process that causes Parkinson's disease but could also play a role in muting the high from methamphetamine and other addictive drugs.

4 May 2009

New idea for Parkinson's treatment

In a study that reveals the clearest picture to date of neuron death in Parkinson's disease, researchers at Columbia University Medical Center have found that a trio of culprits acting in concert is responsible for killing the brain cells.

29 Apr 2009

Brain works best when cells keep right rhythms

It is said that each of us marches to the beat of a different drum, but new Stanford University research suggests that brain cells need to follow specific rhythms that must be kept for proper brain functioning.

26 Apr 2009

MicroRNA may link smoking risk gene to neurobiology of addiction

During the past several years, significant progress has been made in identifying susceptibility genes for nicotine dependence through genetic linkage and association analyses.

23 Apr 2009

Discovery of key processes in the brain that control perception of emotional events

Research performed by Nicole Lauzon and Dr. Steven Laviolette of the Schulich School of Medicine & Dentistry at The University of Western Ontario has found key processes in the brain that control the emotional significance of our experiences and how we form memories of them.

20 Apr 2009

Laughter improves health

The connection between the body, mind and spirit has been the subject of conventional scientific inquiry for some 20 years.

20 Apr 2009

Wrist acupuncture prevents postoperative nausea and vomiting

Up to 80 percent of patients who have surgery complain of nausea and vomiting afterwards, but stimulating an acupoint in their wrists can help reduce these symptoms, finds a new evidence review.

14 Apr 2009

Dopamine agonists trigger destructive behaviors

A new study conducted at Mayo Clinic reports that one in six patients receiving therapeutic doses of certain drugs for Parkinson's disease develops new-onset, potentially destructive behaviors, notably compulsive gambling or hypersexuality.

9 Apr 2009

Obesity and overweight linked to greater risk of restless legs syndrome

A new study shows both obesity and a large belly appear to increase the risk of developing restless legs syndrome (RLS), a common sleep disorder characterized by an irresistible urge to move your legs.

6 Apr 2009

Researchers find direct link between bursting activity of midbrain dopamine neurons and behavior

Researchers are one step closer to understanding the neurobiology that allows people to successfully learn motivated behaviors by associating environmental cues with rewarding outcomes, according to a study published yesterday in the Proceedings of the National Academy of Sciences ' online Early Edition.

6 Apr 2009

Schizophrenia could be caused by faulty signalling in the brain

In the biggest study of its kind, scientists looking in detail at brain samples donated by people with the condition have identified 49 genes that work differently in the brains of schizophrenia patients compared to controls.

2 Apr 2009

Blocking hunger hormone helps fight cocaine addiction

UC Irvine pharmacological researchers have discovered that blocking a hormone related to hunger regulation can limit cocaine cravings.

1 Apr 2009

CSHL neuroscientists propose project to comprehensively map mammalian brain circuits

Thirty-seven scientists from Cold Spring Harbor Laboratory (CSHL) and 20 other major research institutions in the U.S. and Europe have issued a major challenge to the neuroscience community.

1 Apr 2009

Eli Lilly announces inconclusive study results for mGlu2/3 in acute schizophrenia

Eli Lilly and Company has announced inconclusive Phase II clinical trial results from Study HBBI investigating LY2140023 monohydrate, also known as mGlu2/3, for the treatment of patients suffering from acute schizophrenia.

29 Mar 2009

Non-invasive brain scanning technique may trace development of Parkinson's disease

While finding a biomarker for Parkinson's disease that would let physicians screen for or track its progression remains an elusive goal, a team led by a University of Illinois at Chicago neuroscientist has shown that a non-invasive brain scanning technique offers promise.

24 Mar 2009

Experimental Parkinson's therapy may have robust weight-loss effect

A growth factor used in clinical experiments to rescue dying brain cells in Parkinson patients may cause unwanted weight loss if delivered to specific areas of the brain, according to University of Florida researchers in the March online edition of Molecular Therapy.

24 Mar 2009

p11 protein may lead to faster acting antidepressants

Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by current drugs.

23 Mar 2009

FDA approves Symbyax for treatment-resistant depression

The U.S. Food and Drug Administration (FDA) has approved a new indication for Symbyax (olanzapine and fluoxetine HCl capsules), Eli Lilly and Company has announced.

23 Mar 2009

Dopamine News and Research

Latest Dopamine News and Research

Merck Serono starts second phase III trial of Safinamide in advanced Parkinson's

Potential molecular target for new schizophrenia treatments

oct3 protein key to Parkinson's, drug addiction

New idea for Parkinson's treatment

Brain works best when cells keep right rhythms

MicroRNA may link smoking risk gene to neurobiology of addiction

Discovery of key processes in the brain that control perception of emotional events

Laughter improves health

Wrist acupuncture prevents postoperative nausea and vomiting

Dopamine agonists trigger destructive behaviors

Obesity and overweight linked to greater risk of restless legs syndrome

Researchers find direct link between bursting activity of midbrain dopamine neurons and behavior

Schizophrenia could be caused by faulty signalling in the brain

Blocking hunger hormone helps fight cocaine addiction

CSHL neuroscientists propose project to comprehensively map mammalian brain circuits

Eli Lilly announces inconclusive study results for mGlu2/3 in acute schizophrenia

Non-invasive brain scanning technique may trace development of Parkinson's disease

Experimental Parkinson's therapy may have robust weight-loss effect

p11 protein may lead to faster acting antidepressants

FDA approves Symbyax for treatment-resistant depression

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Dopamine News and Research

Latest Dopamine News and Research

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

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