Gene News and Research

Latest Gene News and Research

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

31 Oct 2025

Massive cross-ancestry study explains why obesity risks differ around the world

A massive cross-ancestry genetic study involving over 839,000 adults identified 13 genes linked to obesity, including five never before associated with the condition. The findings highlight how global genetic diversity can uncover new biological pathways and potential treatment targets for obesity.

31 Oct 2025

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

Researchers discovered that bowhead whales achieve extraordinary longevity and cancer resistance through highly efficient and precise DNA repair mechanisms. A whale-specific protein, CIRBP, enhances genome stability even in human cells, revealing a potential pathway to strengthen DNA repair and slow aging.

30 Oct 2025

First-of-its-kind resource created to identify people with genetic risk for elevated 'bad' cholesterol

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource to identify those with a genetic risk for elevated 'bad' cholesterol -- a major contributor to heart disease.

30 Oct 2025

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

30 Oct 2025

Reducing ketone levels and increasing exercise capacity could help manage diabetic ketoacidosis

A researcher at the University of Houston finds management of diabetic ketoacidosis may center around reducing ketone levels in diabetic patients and increasing exercise capacity for better health outcomes.

30 Oct 2025

Understanding the role of m6A methylation in acute lung injury pathogenesis

Acute lung injury (ALI) is a critical clinical condition characterized by diffuse inflammation of the lung parenchyma and intractable hypoxemia, typically caused by factors, such as trauma, pneumonia, shock, and sepsis.

30 Oct 2025

Does fasting earlier in the day improve metabolism? This study says no

In a randomized crossover trial of 31 women with overweight, early and late time-restricted eating (TRE) produced no improvement in insulin sensitivity or cardiometabolic markers under isocaloric conditions. Both schedules, however, shifted internal circadian clocks, highlighting that meal timing affects biological rhythms more than metabolic outcomes.

30 Oct 2025

Research identifies biomarkers in blood to fine-tune breast cancer interventions

Doctors may be able to spare patients unnecessarily aggressive breast cancer treatments by collecting and testing cancer cells in patients' blood, research from the University of Michigan and the University of Kansas suggests.

30 Oct 2025

Rapamycin shows promise in treating cold tumors with specific gene mutation

Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have achieved complete and durable remissions for thousands of people with end-stage metastatic cancers.

29 Oct 2025

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

A systematic review published today in Psychedelics by Mr. James Gattuso and colleagues at the Florey Institute of Neuroscience and Mental Health synthesizes clinical and preclinical evidence on psilocybin's effects on obsessive-compulsive behaviors, revealing consistent therapeutic potential across human patients and validated animal models.

29 Oct 2025

Unlocking memory: The role of epigenetics in memory expression

Our experiences leave traces in the brain, stored in small groups of cells called "engrams". Engrams are thought to hold the information of a memory and are reactivated when we remember, which makes them very interesting to research on memory and age- or trauma-related memory loss.

29 Oct 2025

Fruit flies illuminate the role of Alzheimer's disease risk genes

Scientists have identified hundreds of genes that may increase the risk of developing Alzheimer's disease but the roles these genes play in the brain are poorly understood.

29 Oct 2025

New genetic marker may improve the ability to predict life-threatening reactions to gout medication

A newly identified genetic marker may significantly improve the ability to predict life-threatening reactions to the gout medication allopurinol in U.S. patients.

29 Oct 2025

Understanding age-related changes in T cells and vaccine response

As flu season approaches and public health officials roll out their annual push for vaccination, Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them.

29 Oct 2025

MAGIC: A powerful tool to understand the origin of cancer

The human body relies on precise genetic instructions to function, and cancer begins when these instructions get scrambled.

29 Oct 2025

Harnessing bioinformatics to fast-track the discovery of spinal cord injury drug

Spinal cord injury (SCI) remains a major unmet medical challenge, often resulting in permanent paralysis and disability with no effective treatments.

29 Oct 2025

Specialized type of cardiac fibroblasts can actively worsen heart failure

Heart failure (HF) is one of the leading causes of death and disability worldwide, affecting millions of people and placing an enormous burden on healthcare systems.

29 Oct 2025

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Peripheral afferent neurons - nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord) - are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

29 Oct 2025

Heart ‘blueprint’ offers insights into fetal development and congenital defects

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development.

29 Oct 2025

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Gene News and Research

Latest Gene News and Research

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

Massive cross-ancestry study explains why obesity risks differ around the world

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

First-of-its-kind resource created to identify people with genetic risk for elevated 'bad' cholesterol

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Reducing ketone levels and increasing exercise capacity could help manage diabetic ketoacidosis

Understanding the role of m6A methylation in acute lung injury pathogenesis

Does fasting earlier in the day improve metabolism? This study says no

Research identifies biomarkers in blood to fine-tune breast cancer interventions

Rapamycin shows promise in treating cold tumors with specific gene mutation

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

Unlocking memory: The role of epigenetics in memory expression

Fruit flies illuminate the role of Alzheimer's disease risk genes

New genetic marker may improve the ability to predict life-threatening reactions to gout medication

Understanding age-related changes in T cells and vaccine response

MAGIC: A powerful tool to understand the origin of cancer

Harnessing bioinformatics to fast-track the discovery of spinal cord injury drug

Specialized type of cardiac fibroblasts can actively worsen heart failure

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Heart ‘blueprint’ offers insights into fetal development and congenital defects

eBook: Using iPSCs models for human disease research and drug discovery eBook

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre