Gene News and Research

Latest Gene News and Research

DiffInvex identifies key genes driving chemotherapy resistance

Just as species adapt over generations, our body's cells accumulate DNA changes throughout life. Most are harmless, yet a few "driver" mutations give a cell a competitive edge and can spark cancer.

13 May 2025

New treatment approach boosts survival rates for patients with aggressive, inherited breast cancers

A new treatment approach significantly improves survival rates for patients with aggressive, inherited breast cancers, according to Cambridge researchers.

13 May 2025

Simple oral swab test could revolutionize IVF success rates

About 15 per cent of all couples of reproductive age are involuntarily childless. A major reason why so many need assisted reproduction is that nowadays more and more people are putting off starting a family.

13 May 2025

‘Cell line atlas’ can help better understand biliary tract cancer biology

Advanced biliary tract cancer (BTC) includes cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. BTC is a rare and aggressive group of cancers, carrying one of the worst prognoses in all of oncology.

12 May 2025

Exploring the role of RNA binding proteins and circular RNAs in cancer

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology.

12 May 2025

Review spotlights MYC as a multidimensional therapeutic target in cancer

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional therapeutic target.

12 May 2025

RANBP2 identified as key regulator in the progression of multiple solid tumors

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

12 May 2025

Mitochondrial DNA editing offers new hope for neurodegenerative disease treatment

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs).

12 May 2025

HER3 reemerges as a key driver of cancer progression and therapy resistance

A new publication shines a spotlight on HER3, a long-overlooked member of the ErbB receptor family, revealing its critical role in cancer progression and resistance to therapy.

12 May 2025

Blood-based biomarkers predict therapy failure in prostate cancer patients

New research has identified specific blood-based biomarkers that can predict the failure of prostate cancer treatment in both hormone-sensitive and castration-resistant patients.

12 May 2025

Researchers uncover how Entamoeba histolytica evades the immune system

The single-celled parasite Entamoeba histolytica infects 50 million people each year, killing nearly 70,000. Usually, this wily, shape-shifting amoeba causes nothing worse than diarrhea.

12 May 2025

Scientists link specific gene variants to post-vaccine myocarditis and pericarditis

A genome-wide association study in Sweden identified rare genetic variants near the SCAF11 and LRRC4C genes that may be linked to heart inflammation following COVID-19 mRNA vaccination. The findings shed light on potential biological pathways driving vaccine-associated myocarditis and pericarditis, particularly among younger individuals.

11 May 2025

New human ovaroid model offers insight into infertility and differences in sex development

A new model of tiny human ovary organoids, or ovaroids, has been developed from stem cells, according to research presented at the first Joint Congress between the European Society of Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE).

11 May 2025

Newly identified gene mutation causes severe form of Fanconi anemia

Fanconi anemia is an aggressive, life-threatening disorder. Most individuals living with this rare genetic condition, characterized by bone marrow failure and cancer predisposition, survive into adulthood only with bone marrow transplantation and regular cancer screening.

11 May 2025

Targeting METTL3 may offer new hope for oral cancer treatment

A new research paper was published in Oncotarget, Volume 16, on May 8, 2025, titled "METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis."

11 May 2025

Machine learning model guides smarter gene selection in newborn screening

More than a decade ago, researchers launched the BabySeq Project, a pilot program to return newborn genomic sequencing results to parents and measure the effects on newborn care.

10 May 2025

Unlocking the mechanism behind marine bacterium’s ability to clean up oil spills

The marine bacterium Alcanivorax borkumensis feeds on oil, multiplying rapidly in the wake of oil spills, and thereby accelerating the elimination of the pollution, in many cases.

10 May 2025

Gum disease bacterium linked to increased risk of atrial fibrillation

Tempted to skip the floss? Your heart might thank you if you don't. A new study from Hiroshima University (HU) finds that the gum disease bacterium Porphyromonas gingivalis (P. gingivalis) can slip into the bloodstream and infiltrate the heart.

10 May 2025

Why your baby’s first steps may be written in their DNA

Researchers identified 11 genetic loci linked to the age at which infants start walking, revealing that this milestone is influenced by thousands of common genetic variants. These genetic factors also correlate with brain development, cognitive traits, and neurodevelopmental conditions like ADHD.

8 May 2025

St. Jude Children's scientists use brain organoids to study rare encephalopathy

While extremely rare, encephalopathy (a condition affecting brain function) triggered by mutations in the UBA5 gene has devastating impacts, with affected individuals reaching few developmental milestones and experiencing frequent and early-onset seizures.

8 May 2025