Gene News and Research

Latest Gene News and Research

Study shows how early-life epigenetic 'memory' can influence adult brain inflammation

Why do some people remain healthy through childhood yet become more vulnerable to brain disorders such as dementia later in life? A KAIST (President Kwang Hyung Lee) -led team has uncovered a key part of the answer: a developmental 'switch' in astrocytes—the brain's most abundant support cells that shapes how strongly the brain's immune system reacts in adulthood.

25 Sep 2025

Antidepressant fluoxetine alters brain energy use and boosts neural plasticity

A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain "loosen up" and adapt during depression treatment.

25 Sep 2025

Lysosomal activity in worms linked to transgenerational extension of lifespan

In the Wang Lab, it's not unusual for worms to live for a long time. HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing an enzyme in the lysosomes of the roundworm C. elegans, they can extend the worm's life by up to 60 percent.

25 Sep 2025

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.

25 Sep 2025

Study uncovers how lymphatic endothelial cells assist in generating robust immune memory

A study published today in Nature Communications describes how lymphatic endothelial cells assist in generating robust immune memory, offering new insights into how the immune system functions.

25 Sep 2025

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular carcinoma.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025

Stem cell treatment could help millions of people with end-stage kidney disease

More than 4 million people worldwide have end-stage kidney disease that requires hemodialysis, a treatment in which a machine filters waste from the blood.

24 Sep 2025

Loss of Trp53 gene affects immune responses in ovarian cancer

A new research paper was published in Volume 16 of Oncotarget on September 22, 2025, titled "Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma."

24 Sep 2025

Lifespan study reveals age-specific biological changes in Down Syndrome

In a groundbreaking new study published in Nature Communications, researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado Anschutz discovered important differences in the physiological changes observed in over 300 individuals with Down syndrome across the lifespan.

24 Sep 2025

Reversing age-related vision loss with retinal lipid therapy

Changes in vision are often a common sign of aging. If you sit in a dimly lit restaurant with anyone over the age of 60, you'll likely hear the person say, "Hold on - let me pull out my cell phone. I need more light to read the menu!" But what if we could reverse age-related visual decline?

24 Sep 2025

How food choices and cooking methods drive brain inflammation and disease

Researchers reviewing evidence in NeuroSci show how dietary AGEs and their interaction with RAGE drive oxidative stress, inflammation, and neurodegeneration. They highlight how cooking methods and diet choices could lower AGE burden and protect brain health, while calling for rigorous clinical trials.

24 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

Researchers identify protein crucial for tick-borne encephalitis virus to infect human cells

Researchers at Karolinska Institutet, together with international colleagues, have identified a protein that is crucial for the TBE virus to infect human cells.

24 Sep 2025

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – from acne and psoriasis, to rheumatoid arthritis and inflammatory bowel disease.

24 Sep 2025

Genomic study reveals colonial and Indigenous contributions to modern South Africans

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Gene News and Research

Latest Gene News and Research

Study shows how early-life epigenetic 'memory' can influence adult brain inflammation

Antidepressant fluoxetine alters brain energy use and boosts neural plasticity

Lysosomal activity in worms linked to transgenerational extension of lifespan

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

Study uncovers how lymphatic endothelial cells assist in generating robust immune memory

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Genetic modification enhances "living drugs" for blood cancers

Stem cell treatment could help millions of people with end-stage kidney disease

Loss of Trp53 gene affects immune responses in ovarian cancer

Lifespan study reveals age-specific biological changes in Down Syndrome

Reversing age-related vision loss with retinal lipid therapy

How food choices and cooking methods drive brain inflammation and disease

Scientists outline how future therapies could change type 1 diabetes care

Researchers identify protein crucial for tick-borne encephalitis virus to infect human cells

Scientists show for the first time how fibroblasts go 'rogue' in different diseases

Genomic study reveals colonial and Indigenous contributions to modern South Africans

Research highlights how the gut microbiome can affect epigenetics

Scientists study how nanoplastics transfer across generations

NIH funds USC team to develop a selective Alzheimer’s drug for APOE4 carriers

New screening method boosts efficiency and accuracy of CAST genome editing

eBook: Using iPSCs models for human disease research and drug discovery eBook

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics