Gene News and Research

Latest Gene News and Research

BIA Separations selected to support AveXis’ gene therapy pipeline

BIA Separations, a leading biochromatography development and manufacturing company, today announced it is collaborating with AveXis, a Novartis company, to enhance the commercial purification process for its gene therapy pipeline, beginning with Zolgensma (onasemnogene abeparvovec-xioi), the first U.S. Food and Drug Administration-approved gene therapy indicated for the treatment of pediatric patients with spinal muscular atrophy (SMA) who are less than two years of age.

22 Jul 2019

Scientists confirm HIV theory by sequencing 53-year old tissue

Researchers have extracted a near-complete HIV-1 genome from the lymph node tissue of a man who has been embedded in wax since 1966.

22 Jul 2019

Chemists discover a whole new class of microbial recipes

Microbes are master chefs of the biomolecular world; collectively, they harbor the ability to produce a vast array of unknown substances, some of which may have therapeutic or other useful properties.

22 Jul 2019

Genetic similarities of deadly bone cancer between dogs and children revealed

A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a study published today by Tufts University and the Translational Genomics Research Institute, an affiliate of City of Hope.

21 Jul 2019

Study provides new insight into how changes in DNA methylation contribute to diseases

More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses.

19 Jul 2019

NIH researchers report largest genomic study of type 2 diabetes in sub-Saharan Africans

National Institute of Health researchers have reported the largest genomic study of type 2 diabetes in sub-Saharan Africans, with data from more than 5,000 individuals from Nigeria, Ghana and Kenya.

19 Jul 2019

Disruption of immune cell behavior may spur heart disease, heart failure

On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie.

From Johns Hopkins Medicine 19 Jul 2019

Group of genes linked to longer lifespan in fruit flies discovered

Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies, and co-authors from the Institute of biology of Komi Science Center of RAS, the Engelgard's Institute of molecular biology of RAS and Moscow Institute of Physics and Technology published a scientific article titled "Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity" in Nature Scientific Reports - the leading international multidisciplinary weekly journal.

19 Jul 2019

Study uncovers gene that hides tumor cells from immunotherapy

A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients.

19 Jul 2019

Alzheimer's gene may affect cognitive health before adulthood, study finds

The Apolipoprotein E (APOE) is a major cholesterol carrier that aids in lipid transport and injury repair in the brain. It packages cholesterol and other fats and moves them through the bloodstream. APOE polymorphic alleles are the major genetic factors for the risk of Alzheimer’s disease (AD).

19 Jul 2019

AEBP1 gene may play key role in the development and severity of liver disease

Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute, an affiliate of City of Hope.

18 Jul 2019

Study reveals how aggressive prostate cancer metastasizes by evading the immune system

Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system.

18 Jul 2019

Researchers identify brain somatic mutations linked to Alzheimer's disease

Researchers have identified somatic mutations in the brain that could contribute to the development of Alzheimer's disease. Their findings were published in the journal Nature Communications last week.

18 Jul 2019

Researchers develop a more precise version of CRISPR-Cas9 gene-editing system

A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model.

18 Jul 2019

Researchers reveal molecular cause for severe multi-organ disorder

Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare disease.

18 Jul 2019

Research team detects novel mechanism of inheritance

Non-Mendelian, oligogenic inheritance could bean unrecognized and important element for occurrence ofhereditary retinal degenerations (HRDs, comprising retinitis pigmentosa) which are caused by ultra-rare mutations and cause progressive blindness.

18 Jul 2019

Novel insight into microRNA function can be crucial for the development of gene therapy

Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei.

18 Jul 2019

Light at last: why do more women develop Alzheimer’s disease?

Alzheimer’s disease (AD) is a leading cause of dementia in many older people, but it seems to affect twice as many women as men. Scientists have long tried to find out why this is so, and why it seems to follow a fast-track course in women.

18 Jul 2019

Human genotype determines if a given Alzheimer's drug will be effective

University at Buffalo researchers have determined that a human gene present in 75 % of the population is a key reason why a class of drugs for Alzheimer's disease seemed promising in animal studies only to fail in human studies.

18 Jul 2019

New research could help design algae that produces fuels and cleanup chemicals

It's a case of grand larceny that could lead to new fuels and cleanup chemicals. Ten species of red algae stole about 1 percent of their genes from bacteria to cope with toxic metals and salt stress in hot springs, according to a study in the journal eLife.

18 Jul 2019