Inflammatory Bowel Disease News and Research

Latest Inflammatory Bowel Disease News and Research

Vitamin D may help shape how the immune system responds to gut bacteria in IBD patients

Vitamin D supplementation may help shape how the immune system responds to gut bacteria in people with inflammatory bowel disease (IBD), according to a Mayo Clinic–led study published in Cell Reports Medicine.

26 Mar 2026

Whole wheat diets may reduce the risk of inflammatory bowel disease

Enriching the diet with wheat fiber protects mice against intestinal inflammation, according to a study published by researchers in the Institute for Biomedical Sciences (IBMS) at Georgia State University.

25 Mar 2026

IGFBP1 identified as potential biomarker for IBD monitoring in elderly patients

A recent study published in Current Molecular Pharmacology highlights the potential of insulin-like growth factor binding protein 1 (IGFBP1) as a monitoring biomarker for disease activity in elderly patients with inflammatory bowel disease (IBD).

24 Mar 2026

Machine learning speeds up AMP discovery for treating ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent intestinal inflammation, abdominal pain and diarrhea.

23 Mar 2026

How one antibiotic dose can reshape your gut microbiome for years

Long-term registry-linked analysis of nearly 15,000 adults shows that antibiotic use is associated with persistent changes in gut microbiome diversity and composition for up to 4–8 years. These effects vary by antibiotic class, with clindamycin, fluoroquinolones, and flucloxacillin showing the strongest and most sustained associations.

17 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

New collaboration explores familial inflammatory bowel disease in Saudi Arabia

Mount Sinai and King Saud University Medical City in Riyadh, Saudi Arabia, today announced a three-year collaboration aimed at better understanding why inflammatory bowel disease (IBD) runs in some Saudi families, and how that knowledge can lead to risk ascertainment, earlier diagnosis and more personalized treatment options.

3 Mar 2026

New research initiative aims to predict and prevent diseases before they start

What if doctors could tell you a disease was coming years before you felt a single symptom-and stop it in its tracks? That is the goal of a sweeping new research initiative launched by the Icahn School of Medicine at Mount Sinai in collaboration with the Uniformed Services University of the Health Sciences (USU) and the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF).

2 Mar 2026

Forecasting disease intensity through genomic risk

Approximately 60,000 Danes live with chronic inflammatory bowel disease. Some experience limited discomfort, while others go through a debilitating disease course involving surgery and a stoma. Add to this the fear of leaving home due to urgent toilet needs.

2 Mar 2026

Tick-derived protein discovery can advance treatment for inflammatory diseases

When the immune system detects a harmful or foreign agent it triggers an inflammatory response small proteins called chemokines direct immune cells to the site of the injury or infection, resulting in the invader being inactivated.

27 Feb 2026

Routine terminal ileum intubation and biopsy: A standard practice for colonoscopy completion

Terminal ileum intubation is considered the completion step of colonoscopy and is usually performed to assess the ileum.

27 Feb 2026

Distinct gut toxicity patterns emerge with targeted cancer treatments

A new paper was published in Volume 13 of Oncoscience on February 6, 2026, titled "Gastrointestinal toxicity of targeted cancer therapies in the United States: Clinicopathologic patterns, FDA safety frameworks, and implications for national patient protection."

20 Feb 2026

Blood markers can indicate people at risk of developing ulcerative colitis

Researchers at örebro University have identified blood markers that can indicate who is at risk of developing ulcerative colitis - a chronic inflammatory bowel disease - later in life.

20 Feb 2026

Developmental ANGPTL4 deficiency protects mice from colitis and tumors

A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development triggers a long-lasting reprogramming of the immune system that protects against intestinal inflammation.

18 Feb 2026

AI tool can accurately predict colorectal cancer risk in UC-LGD patients

People with ulcerative colitis (UC), a chronic inflammatory bowel disease, are up to four times more likely to develop colorectal cancer than the general population.

17 Feb 2026

Dysplasia grade predicts colorectal cancer risk in people with IBD

People with inflammatory bowel disease (IBD) and precancerous colorectal lesions are much more likely to develop colorectal cancer, a new study shows.

16 Feb 2026

Stress hormones rewire immune system during periods of food scarcity

When food is scarce, stress hormones direct the immune system to operate in "low power" mode to preserve immune function while conserving energy, according to researchers at Weill Cornell Medicine.

10 Feb 2026

Time-restricted feeding reduces disease activity and inflammation in Crohn's patients

A new randomized controlled study funded by the Crohn's & Colitis Foundation found that time-restricted feeding-a form of intermittent fasting-significantly reduced symptomatic disease activity and systematic inflammation in adults with Crohn's disease and overweight or obesity.

9 Feb 2026

Ulcerative proctitis not linked to increased rectal cancer risk

People with ulcerative proctitis, a milder and more limited form of ulcerative colitis, are not at higher risk of developing rectal cancer than the general population.

5 Feb 2026