Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is an ongoing or chronic health problem that causes inflammation and swelling in the digestive tract. The irritation causes bleeding sores called ulcers to form along the digestive tract. This in turn can cause crampy, abdominal pain and severe bloody diarrhea.

What is Ulcerative Colitis?

Ulcerative colitis is a chronic condition that affects the large intestines, particularly the colon. It is classified as one of the two inflammatory bowel diseases along with Crohn’s disease.

Ulcerative Colitis Causes

Genetics of Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease (IBD) in Pregnancy

Dysbiosis and the Microbiome

Mesentery: a new organ?

FODMAP Research

Inflammatory Bowel Disease and Colorectal Cancer

Short-Chain Fatty Acids (SCFAs)

Latest Inflammatory Bowel Disease News and Research

Associations between gut microbes and Alzheimer’s disease

Researchers reviewed existing data on the role of the gut microbiome in Alzheimer’s disease (AD) pathogenesis.

24 Jul 2024

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

Western diets linked to increased risk of IBD and colorectal cancer

Western diets pose a greater risk of Inflammatory Bowel Disease (IBD) and colorectal cancer, according to a milestone review of what people eat around the world.

18 Jul 2024

Gut microbiome health crucial to survival after solid organ transplants

'Unhealthy' gut microbiome patterns are linked to a heightened risk of death after a solid organ transplant, finds research published online in the journal Gut.

9 Jul 2024

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

In the gut, dozens of strains of bacteria exert different effects on the immune system that in turn impact our health – fending off pathogens, helping digest food and maybe even influencing behavior. But pinpointing which bacteria exert which effects has been challenging.

4 Jul 2024

Researchers discover rare types of helper T cells associated with immune disorders

Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical Sciences (IMS) and Kyoto University in Japan and IFOM ETS in Italy have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma.

4 Jul 2024

New light-activated method targets cancer and inflammatory cells with precision

A new method of precisely targeting troublesome cells for death using light could unlock new understanding of and treatments for cancer and inflammatory diseases, University of Illinois Urbana-Champaign researchers report.

1 Jul 2024

New method developed to map mechanistic connections between diseases

Tampere University researchers developed a method to map mechanistic connections between diseases, revealing deeper associations beyond traditional classifications based on affected organs and symptoms.

28 Jun 2024

New study casts doubt on lipid-lowering strategies for IBD prevention

A new study has illuminated the connection between inflammatory bowel disease (IBD) and lipid profile. IBD is a chronic condition that causes inflammation in the intestines. Abnormal lipid factor levels such as cholesterol in IBD patients have been observed in previous studies, but whether this association is causal remained unclear.

28 Jun 2024

WEHI study reveals new methods in detecting necroptosis

Fully automated diagnostic techniques, including liquid handling robots, are poised to improve the lives of millions of people living with inflammatory diseases worldwide.

24 Jun 2024

Challenges in treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a rare progressive liver disease that damages bile ducts and significantly increases the risk of bile duct cancer, particularly a type called cholangiocarcinoma (CCA).

20 Jun 2024

New research sheds light on IL-23's role in chronic inflammatory bowel diseases

Scientists at Weill Cornell Medicine discovered a previously unknown link between two key pathways that regulate the immune system in mammals-;a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD).

12 Jun 2024

Understanding Crohn's disease through 'mini-gut' models

Cambridge scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease and how it presents in patients.

10 Jun 2024

Genetic discovery reveals key to inflammatory diseases

Researchers discovered that a specific haplotype on chromosome 21 is linked to five inflammatory diseases, offering insights into potential new treatments.

7 Jun 2024

Researchers discover new biological pathway that drives inflammatory bowel disease

Researchers at the Francis Crick Institute, working with UCL and Imperial College London, have discovered a new biological pathway that is a principal driver of inflammatory bowel disease (IBD) and related conditions, and which can be targeted using existing drugs.

5 Jun 2024

The role of banana lectin in mitigating inflammatory bowel disease

The therapeutic role of recombinant banana lectin (rBanLec) concerning IBD control and raising vaccination rates.

3 Jun 2024

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

The effects of statins via inhibition of interleukin 33 (IL-33).

3 Jun 2024

Study reveals significant link between rosacea and malignant melanoma

Rosacea, a common skin condition widely considered to be only a cosmetic issue, could be associated with several comorbidities, including melanomas.

28 May 2024

Study demonstrates causal link between microbial factors and dysfunction of ISCs in colitis

In a study published in Cell Host & Microbe, a research team led by Prof. PAN Wen from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, in collaboration with research teams led by Prof. ZHU Shu and Prof. SONG Xinyang, demonstrated the causal link between microbial factors and dysfunction of intestinal stem cells (ISCs) in colitis.

23 May 2024

Insilico Medicine's leadership to address key challenges in AI drug discovery at BIO Convention

Leadership from clinical stage artificial intelligence (AI)-powered drug discovery company Insilico Medicine ("Insilico") will attend the BIO International Convention in San Diego June 3-6 and present on key issues facing AI drug discovery.

23 May 2024