Metabolism News and Research

Latest Metabolism News and Research

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown.

8 Feb 2021

Scientists grow small intestinal cells from human-induced pluripotent stem cells

A team of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells.

8 Feb 2021

Study reveals a novel role for Smurf2 protein in regulating bone formation

Bone morphogenetic protein (BMP) has a strong osteogenic (bone forming) ability. BMP has already been clinically applied to spinal fusion and non-union fractures.

8 Feb 2021

Technion team discovers new process for attacking cancer cells

When treating cancer, researchers are always searching for ways to remove cancer cells while minimizing damage to the rest of the body. One possible approach is to find processes unique to cancer cells, and which would allow specific targeting. If such a process can be disrupted, only those cells would be affected.

6 Feb 2021

Small wearable sensor can detect stress biomarker in sweat

We've all felt stressed at some point, whether in our personal or professional lives or in response to exceptional circumstances like the COVID-19 pandemic. But until now there has been no way to quantify stress levels in an objective manner.

6 Feb 2021

Ancestral components of human gut microbiota are fundamental to health

Neanderthals' gut microbiota already included some beneficial micro-organisms that are also found in our own intestine.

5 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Pharmacologist lays out a plan to improve the equity of drug development

In a new perspective piece published in the Feb. 5 issue of Science, pharmacologist Namandje Bumpus, Ph.D. -- who recently became the first African American woman to head a Johns Hopkins University School of Medicine department, and is the only African American woman leading a pharmacology department in the country -- outlines the molecular origins for differences in how well certain drugs work among distinct populations.

4 Feb 2021

Researchers call for trials of rapamycin to treat COVID-19

Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.

4 Feb 2021

Alzheimer's risk gene can increase COVID-19 susceptibility and severity

A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19.

4 Feb 2021

Paternal early life stress linked to child's brain development

The FinnBrain research of the University of Turku has demonstrated for the first time that the stress the father has experienced in his childhood is connected to the development of the white matter tracts in the child's brain.

4 Feb 2021

Study shows that human hormones also follow a seasonal pattern

Our minds may be affected by winter's long nights or spring's flowers, but what about our bodies? A new study at the Weizmann Institute of Science reveals that our hormones also follow a seasonal pattern.

4 Feb 2021

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Hypoxia -- where a tissue is deprived of an adequate supply of oxygen -- is a feature inside solid cancer tumors that renders them highly invasive and resistant to treatment. Study of how cells adapt to this critical stressor, by altering their metabolism to survive in a low-oxygen environment, is important to better understand tumor growth and spread.

4 Feb 2021

Scientists receive award to explore how diet and metabolism influence the immune system

A pair of scientists from Van Andel Institute and the National Institute of Allergy and Infectious Diseases have been granted a three-year, $1.5 million Allen Distinguished Investigator award from The Paul G. Allen Frontiers Group, a division of the Allen Institute, to better understand how diet and metabolism influence the immune system's ability to fight off threats such as infections.

3 Feb 2021

Extreme blood sugar swings in patients with type 2 diabetes linked to high risk of heart disease

In patients with type 2 diabetes, big swings in blood sugar levels between doctors' visits are associated with an increased risk of heart disease.

3 Feb 2021

Two studies describe processes that affect the generation of new fat cells

Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases.

3 Feb 2021

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

A new study by researchers at the University of Manchester, UK, reports on the compounds of interest that were identified as having potential for the treatment of COVID-19, from a library of almost 2,000 compounds from the APExBIO DiscoveryProbe library.

3 Feb 2021

Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

A new study describes the antiviral activity of oxysterols, or oxidized cholesterol derivatives, against SARS-CoV-2. These occur in nature, and are not only involved in lipid signaling pathways that modulate a host of processes within the body, including the immune response and lipid homeostasis.

3 Feb 2021

Childhood diet can alter the gut microbiome for life

Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests.

3 Feb 2021

Study: Brain hormones could improve metabolism and fight obesity

A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice.

3 Feb 2021

Metabolism News and Research

Latest Metabolism News and Research

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Scientists grow small intestinal cells from human-induced pluripotent stem cells

Study reveals a novel role for Smurf2 protein in regulating bone formation

Technion team discovers new process for attacking cancer cells

Small wearable sensor can detect stress biomarker in sweat

Ancestral components of human gut microbiota are fundamental to health

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Pharmacologist lays out a plan to improve the equity of drug development

Researchers call for trials of rapamycin to treat COVID-19

Alzheimer's risk gene can increase COVID-19 susceptibility and severity

Paternal early life stress linked to child's brain development

Study shows that human hormones also follow a seasonal pattern

Chronic hypoxia upregulates RNA polymerase I, alters methylation on ribosomal RNAs

Scientists receive award to explore how diet and metabolism influence the immune system

Extreme blood sugar swings in patients with type 2 diabetes linked to high risk of heart disease

Two studies describe processes that affect the generation of new fat cells

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

Oxysterol derivatives show powerful antiviral activity against SARS-CoV-2 in vitro

Childhood diet can alter the gut microbiome for life

Study: Brain hormones could improve metabolism and fight obesity

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting