Metabolism News and Research

Latest Metabolism News and Research

Vigorous exercise results in stronger bones, reduced diabetes risk and less visceral fat

Cells in bone, fat and the pancreas appear to be talking to each other and one thing they likely are saying is, "Get moving."

20 Sep 2011

Preclinical studies shows EmPAC more effective than Taxol

Cornerstone Pharmaceuticals, Inc. has announced the publication of data from preclinical studies on EmPAC™, its nanoparticle reformulation of paclitaxel, in the August issue of the Journal of Nanoscience and Nanotechnology. The publication highlights data demonstrating improved safety and efficacy of EmPAC™ versus Taxol®, the generic formulation of paclitaxel and one of the most widely prescribed chemotherapies. EmPAC™ is a nanoemulsion formulation of Paclitaxel and is the lead product candidate of Cornerstone’s proprietary Emulsiphan™ cancer selective delivery nanotechnology platform. Taxol®, an injectable formulation of Paclitaxel, is currently used to treat a variety of cancers, including ovarian carcinomas, breast cancer, non-small cell lung cancer, and AIDS-related Kaposi’s sarcoma.

19 Sep 2011

Phenex commences Px-102 first-in-man Phase I study for Metabolic Syndrome and NAFLD

Phenex Pharmaceuticals AG announced today the start of a first-in-man Phase I study with its clinical drug candidate Px-102, a synthetic non-steroidal FXR agonist. The volunteers of the first dose level received the drug and showed no signs of discomfort or other adverse effects.

19 Sep 2011

High-fat maternal diet during pregnancy results in deposition of excess body fat in the newborn

New research in mice indicates that babies born to moms who eat a high-fat diet before and during pregnancy have a higher fat mass and smaller livers than babies whose moms consume low-fat fare, according to scientists at Oregon Health & Science University Doernbecher Children's Hospital.

17 Sep 2011

Study reveals altered digestive genes in children with autism and gastrointestinal disturbances

Researchers at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health and at the Harvard Medical School report that children with autism and gastrointestinal disturbances have altered expression of genes involved in digestion. These variations may contribute to changes in the types of bacteria in their intestines.

17 Sep 2011

DARA's KRN5500 meets primary end-points in Phase II study for chemotherapy-induced neuropathic pain

Thanks to greater awareness, earlier detection and improving therapeutic agents, people with cancer are living longer than ever before. One of the consequences of living longer is the symptom burden of cancer survivorship, which may have a substantial impact on quality of life for many survivors. One such burden is the pain syndromes resulting from cancer treatments.

17 Sep 2011

Potential new treatment for fragile X syndrome

Researchers at Vanderbilt University Medical Center, in collaboration with Seaside Therapeutics in Cambridge, Mass., have achieved a milestone in the development of a potential new treatment for fragile X syndrome, the most common genetic cause of autism.

16 Sep 2011

GSM signal from mobile phones suppresses glucose metabolism in brain

Recent PET-measurements in Turku, Finland, show that the GSM mobile phone electromagnetic field suppresses glucose metabolism in temporoparietal and anterior temporal areas of the hemisphere next to the antenna.

16 Sep 2011

Roche, Uppsala BIO partner for new open innovation program

Swedish life science initiative Uppsala BIO has formed a strategic partnering agreement with Roche, the world leading pharmaceuticals and diagnostics company, for Uppsala BIO's open innovation program, BIO-X.

15 Sep 2011

Glucose metabolism inhibition with 2-DG induces cell death in alveolar rhabdomyosarcoma

A study made by IDIBELL researchers shows that glucose metabolism inhibition with 2-deoxyglucose (2-DG) induces cell death in a type of childhood sarcoma: alveolar rhabdomyosarcoma.

15 Sep 2011

Natural S-equol supplement does not increase risk of estrogen-sensitive breast cancer

Consuming the soy germ-based compound Natural S-equol and the supplement SE5-OH containing Natural S-equol did not increase the risk of estrogen-sensitive breast cancer, according to a study in the September issue of the peer-reviewed journal Food and Chemical Toxicology.

14 Sep 2011

Black women with wide waists are equally at risk of early death as whites

Ever since the mid-1970s when Harvard initiated what is now known as "The Nurses Study" we've been told that white women with waists over 40 inches, raised their risk of early death by 40% vs. their slimmer sisters who maintained waists in the 26 to 27 inch measure.

14 Sep 2011

Pure maple syrup may promote a healthy liver

New research conducted at the University of Tokyo suggests that pure maple syrup may promote a healthy liver.

14 Sep 2011

Health Canada approves Afinitor for treatment of brain tumours caused by TSC in children

Families with children suffering from brain tumours caused by an uncommon genetic disorder known as Tuberous Sclerosis Complex (TSC) have new hope with Health Canada's recent conditional approval of a new therapeutic use for the drug Afinitor (everolimus). Afinitor is the first drug therapy approved in Canada for the treatment of brain tumours caused by TSC in patients three years of age and older.

14 Sep 2011

A squirt of insulin up the nose for prevention of Alzheimer’s disease

Researchers have noted in a small pilot study that squirting insulin deep into the nose where it travels to the brain might hold early Alzheimer’s disease at bay. At present there are no effective ways to prevent or delay the progress of Alzheimer’s. More than 5.4 million Americans and 35 million people worldwide have Alzheimer's, the most common form of dementia.

13 Sep 2011

Cancer prevention tips for men at every stage of life

Men who maintain a healthy body throughout life are often better able to fight off diseases like cancer. That's why experts at The University of Texas MD Anderson Cancer Center have created a guide with cancer prevention tips to help men at every stage of life.

13 Sep 2011

Cardiotrophin 1 has marked effect on fat and glucose metabolism

Scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra (Spain) have discovered that cardiotrophin 1, a protein synthesized by muscle cells and adipose tissue, has a marked effect on fat and glucose metabolism.

13 Sep 2011

Researchers identify glucokinase triggers beta cell regeneration in pancreas

Researchers at the Hebrew University of Jerusalem have identified the key signal that prompts production of insulin-producing beta cells in the pancreas -- a breakthrough discovery that may ultimately help researchers find ways to restore or increase beta cell function in people with type 1 diabetes.

12 Sep 2011

Roche initiates Phase 1 clinical trial of investigational drug for Down syndrome

Roche today announced the initiation of its first Phase 1 clinical trial to investigate the safety and tolerability of a molecule designed to address the cognitive and behavioral deficits associated with Down syndrome.

12 Sep 2011

Autophagy also mobilizes and exports cholesterol from cells

Researchers at the University of Ottawa Heart Institute (UOHI) have discovered that an ancient pathway called autophagy also mobilizes and exports cholesterol from cells.

9 Sep 2011

Metabolism News and Research

Latest Metabolism News and Research

Vigorous exercise results in stronger bones, reduced diabetes risk and less visceral fat

Preclinical studies shows EmPAC more effective than Taxol

Phenex commences Px-102 first-in-man Phase I study for Metabolic Syndrome and NAFLD

High-fat maternal diet during pregnancy results in deposition of excess body fat in the newborn

Study reveals altered digestive genes in children with autism and gastrointestinal disturbances

DARA's KRN5500 meets primary end-points in Phase II study for chemotherapy-induced neuropathic pain

Potential new treatment for fragile X syndrome

GSM signal from mobile phones suppresses glucose metabolism in brain

Roche, Uppsala BIO partner for new open innovation program

Glucose metabolism inhibition with 2-DG induces cell death in alveolar rhabdomyosarcoma

Natural S-equol supplement does not increase risk of estrogen-sensitive breast cancer

Black women with wide waists are equally at risk of early death as whites

Pure maple syrup may promote a healthy liver

Health Canada approves Afinitor for treatment of brain tumours caused by TSC in children

A squirt of insulin up the nose for prevention of Alzheimer’s disease

Cancer prevention tips for men at every stage of life

Cardiotrophin 1 has marked effect on fat and glucose metabolism

Researchers identify glucokinase triggers beta cell regeneration in pancreas

Roche initiates Phase 1 clinical trial of investigational drug for Down syndrome

Autophagy also mobilizes and exports cholesterol from cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut