Metabolism News and Research

Latest Metabolism News and Research

Dysregulation of CISTR-ACT causes brachydactyly type E

The patients have single short fingers (metacarpals) and toes (metatarsals) and can be restricted in growth due to a shortened skeleton. This hereditary disease is called brachydactyly type E (Greek for short fingers).

6 Nov 2012

Soy products do not prevent onset of vasomotor symptoms in women

A team of investigators led by UC Davis found that eating soy products such as soy milk and tofu did not prevent the onset of hot flashes and night sweats as women entered menopause.

2 Nov 2012

High blood cholesterol far more common than previously recognized

High blood cholesterol, a serious hereditary disease, is far more common than previously recognised and not treated sufficiently.

2 Nov 2012

CSHL scientists discover new way to specifically target and kill cancer cells

Cancer cells grow fast. That's an essential characteristic of what makes them cancer cells. They've crashed through all the cell-cycle checkpoints and are continuously growing and dividing, far outstripping our normal cells. To do this they need to speed up their metabolism.

1 Nov 2012

Nitisinone treatment effectively prevents tyrosinemia in children

A consortium of Quebec researchers coordinated by the Medical Genetics Service of the Sainte-Justine UHC has just published the findings of a 25-year study on the treatment of tyrosinemia, a life-threatening liver disease of genetic origin, which is screened at birth in the province of Quebec, where it is much more frequent than anywhere else in the world.

1 Nov 2012

Sprint Bioscience, TPP partner to develop small molecule inhibitors of choline kinase for cancer

TPP Global Development Ltd (TPP) enters into a collaboration with Sprint Bioscience AB to develop small molecule inhibitors of choline kinase as human therapeutics for the treatment of cancer.

30 Oct 2012

Positive interim data from XBiotech monoclonal antibody Phase II study for type 2 diabetes

XBiotech, a privately held biotechnology company, announced positive interim analysis results today from a Phase II study using a True Human monoclonal antibody (MABp1) in patients with type 2 diabetes. Results from this study continue to reinforce the role of IL-1α as a master regulator of chronic inflammation in multiple disease states, and the therapeutic benefits of neutralizing antibodies produced from the XBiotech platform.

29 Oct 2012

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Doxorubicin, a 50-year-old chemotherapy drug still in widespread use against a variety of cancers, has long been known to destroy heart tissue, as well as tumors, in some patients.

29 Oct 2012

Resveratrol does not appear to offer metabolic benefits in healthy women

Resveratrol, an ingredient in red wine thought to improve insulin sensitivity, reduce risk of heart disease and increase longevity, does not appear to offer these benefits in healthy women, new research at Washington University School of Medicine in St. Louis indicates.

26 Oct 2012

Study identifies essential mechanism that regulates calcium flow into mitochondria

Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell's energy storehouse - the mitochondria -- is important for understanding a cell's normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.

26 Oct 2012

Sevoflurane, propofol produce different metabolic patterns in brains of unconscious children

Two commonly used anesthetics produce different metabolic patterns in the brains of unconscious children, according to a study from the November issue of a Anesthesiology.

26 Oct 2012

Study indicates that Firemaster 550 is an endocrine disruptor

The flame-retardant mixture known as "Firemaster 550" is an endocrine disruptor that causes extreme weight gain, early onset of puberty and cardiovascular health effects in lab animals, according to a new study spearheaded by researchers from North Carolina State University and Duke University.

25 Oct 2012

New biomarker measures aggressiveness of primary prostate tumors

Research out of Roswell Park Cancer Institute (RPCI) supports the adoption of a new biomarker to measure the aggressiveness of primary prostate tumors.

24 Oct 2012

TSRI scientists to study structural rules that govern nuclear receptors

A consortium of scientists from both campuses of The Scripps Research Institute (TSRI) has been awarded $2.7 million from the National Institute of General Medical Sciences of the National Institutes of Health to study the structural rules that govern a large superfamily of proteins that help regulate critical functions such as reproduction, development and metabolism.

24 Oct 2012

Old Order Amish children less likely to be overweight

Old Order Amish children are much more physically active and three times less likely to be overweight than non-Amish children, which may provide them with some long-term protection against developing Type 2 diabetes, University of Maryland School of Medicine researchers report in the journal Diabetes Care.

24 Oct 2012

Metabolic pathway for insulin effects of sleep identified

Sleep deprivation reduces insulin sensitivity in human fat cells, which could, over time, lead to metabolic disorders such as diabetes, researchers report.

23 Oct 2012

Rhythm presents RM-131 Phase 1 clinical trial results for diabetic gastroparesis at ACG 2012

Rhythm announced today the results of two Phase 1 clinical trials of RM-131, the company's novel ghrelin agonist for the treatment of diabetic gastroparesis, which demonstrated that RM-131 greatly accelerates gastric emptying in healthy subjects with good tolerability.

22 Oct 2012

Studies explore mechanisms linked to self-control

Converging scientific evidence - not to mention a great deal of life experience - tells us that self-control is an important ability. It helps us keep our cool, get things done, and resist the things that tempt us. Scientists believe that gaining a clearer understanding of how self-control works could provide critical insights into addressing some of the large-scale problems facing society today, including obesity and addiction.

20 Oct 2012

$Researchers find new way to assess risk of osteoporosis, bone fractures in women$

Researchers find new way to assess risk of osteoporosis, bone fractures in women

For women of mixed racial or ethnic backgrounds, a new method for measuring bone health may improve the odds of correctly diagnosing their risk of osteoporosis and bone fractures, according to a UCLA-led study.

20 Oct 2012

Lipid droplets play an unexpected role in embryo development

Histones are proteins needed to assemble DNA molecules into chromosomes. They have long represented a classic balancing act in biology; too few histone molecules result in DNA damage, while too many histones are toxic to the cell. New research at the University of Rochester is causing a fundamental shift in the concept of histone balance and the mechanism behind it.

19 Oct 2012

Metabolism News and Research

Latest Metabolism News and Research

Dysregulation of CISTR-ACT causes brachydactyly type E

Soy products do not prevent onset of vasomotor symptoms in women

High blood cholesterol far more common than previously recognized

CSHL scientists discover new way to specifically target and kill cancer cells

Nitisinone treatment effectively prevents tyrosinemia in children

Sprint Bioscience, TPP partner to develop small molecule inhibitors of choline kinase for cancer

Positive interim data from XBiotech monoclonal antibody Phase II study for type 2 diabetes

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Resveratrol does not appear to offer metabolic benefits in healthy women

Study identifies essential mechanism that regulates calcium flow into mitochondria

Sevoflurane, propofol produce different metabolic patterns in brains of unconscious children

Study indicates that Firemaster 550 is an endocrine disruptor

New biomarker measures aggressiveness of primary prostate tumors

TSRI scientists to study structural rules that govern nuclear receptors

Old Order Amish children less likely to be overweight

Metabolic pathway for insulin effects of sleep identified

Rhythm presents RM-131 Phase 1 clinical trial results for diabetic gastroparesis at ACG 2012

Studies explore mechanisms linked to self-control

Researchers find new way to assess risk of osteoporosis, bone fractures in women

Lipid droplets play an unexpected role in embryo development

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