Neurofibromatosis

Neurofibromatosis is a genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance. Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow. Also called acoustic neurofibromatosis and NF2.

Neurofibromatosis Type 1 Symptoms and Features

The symptoms of neurofibromatosis vary widely between individuals, with some people only experiencing mild health problems and others finding they are severely affected on a day-to-day basis.

What is Neurofibromatosis?

Neurofibromatosis Type 1 Treatment

Neurofibromatosis Type 1 Causes and Diagnosis

Neurofibromatosis Type 2

Neurofibromatosis Type 2 Causes and Diagnosis

Neurofibromatosis Type 2 Symptoms

Neurofibromatosis Type 2 Management

Von Recklinghausen Disease (Neurofibromatosis Type I)

Latest Neurofibromatosis News and Research

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

An unexpected discovery made by experts at the Brain Tumor Center at Cincinnati Children's while studying a rare-but-deadly type of brain tumor may also lead to improved treatments for several other forms of cancer that share a common influencing factor called a YAP fusion protein.

2 Feb 2023

Distinct genomic patterns of malignant peripheral nerve sheath tumors may help with early diagnosis

Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer.

4 Jan 2023

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients.

16 Dec 2022

New study to investigate focused ultrasound's role in addressing neurofibromatosis type 2

The Focused Ultrasound Foundation and the Children's Tumor Foundation (CTF) have established a partnership to advance innovative, noninvasive treatments in pediatrics.

21 Jul 2022

Parents become drug developers to save their children’s lives

Maggie Carmichael wasn't developing like other kids. As a toddler, she wasn't walking and had a limited vocabulary for her age.

21 Jul 2022

Epilepsy drug inhibits the growth of NF1 tumors in mice

People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. These tumors are usually benign -; meaning they don't spread to other parts of the body and are not considered life-threatening -; but they can still cause serious medical problems such as blindness, especially when they form in the brain and nerves.

19 May 2022

Children’s National performs first-ever HIFU surgery on a pediatric patient with neurofibromatosis

Children's National Hospital successfully performed the first-ever high-intensity focused ultrasound (HIFU) surgery on a pediatric patient with neurofibromatosis (NF).

9 Feb 2022

Researchers discover why people with asthma have lower brain tumor risk

There's not much good that can be said about asthma, a breathing disease in which the airways become narrowed and inflamed.

11 Dec 2021

Studies outlines novel strategies for detecting cancer and minimal residual disease

The latest special issue of PLOS Medicine features five studies outlining novel strategies for detecting cancer and for identifying minimal residual disease-; when a small number of tumor cells survive treatment, potentially leading to recurrence of cancer.

1 Sep 2021

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Liquid biopsies detect tumor DNA in blood or urine samples. Two studies led by Washington University School of Medicine in St. Louis describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors.

31 Aug 2021

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

People with an inherited condition known as neurofibromatosis type 1, or NF1, often develop non-cancerous, or benign, tumors that grow along nerves. These tumors can sometimes turn into aggressive cancers, but there hasn't been a good way to determine whether this transformation to cancer has happened.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Researchers at Children's National Hospital identified a vulnerability in a developmental signaling pathway that can be hijacked to drive pediatric low-grade glioma (pLGG) formation, according to a pre-clinical study published in Developmental Cell.

23 Aug 2021

Antihypertension drug may benefit patients with neurofibromatosis type 2

New research led by investigators at Massachusetts General Hospital and Massachusetts Eye and Ear indicates that the blood pressure drug losartan may benefit patients with neurofibromatosis type 2 (NF2), a hereditary condition associated with vestibular schwannomas, or noncancerous tumors along the nerves in the brain that are involved with hearing and balance.

15 Jul 2021

Optic nerve activity may trigger the formation of vision-harming tumors in children

In a study of mice, researchers showed how the act of seeing light may trigger the formation of vision-harming tumors in young children who are born with neurofibromatosis type 1 (NF1) cancer predisposition syndrome.

2 Jun 2021

Sodium fluorescein may improve the safety and outcomes of vestibular schwannoma surgery

Removing a vestibular schwannoma -; a slow-growing, benign tumor that develops in the nerves connecting the inner ear to the brain -; is a delicate procedure. Surgeons must differentiate the tumor from nearby nerves, arteries, and other intracranial structures.

26 Jan 2021

New drug reduces tumor volume and pain in patients with neurofibromatosis type 1

Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1).

15 Jan 2021

Researchers identify a compound that inhibits growth of schwannomas

Schwannomas are tumors of the peripheral nervous system, which often occur in the genetic disease neurofibromatosis type 2. The research group of Prof. Dr. Helen Morrison at the Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, identified a compound that inhibits the growth of such tumors and improves nerve function.

21 Sep 2020

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.

8 Sep 2020

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved.

23 Jul 2020

Neurofibromatosis

Overview

What is Neurofibromatosis?

Neurofibromatosis Type 1 Treatment

Neurofibromatosis Type 1 Causes and Diagnosis

Feature Articles

Neurofibromatosis Type 2

Neurofibromatosis Type 2 Causes and Diagnosis

Neurofibromatosis Type 2 Symptoms

Neurofibromatosis Type 2 Management

Von Recklinghausen Disease (Neurofibromatosis Type I)

Latest Neurofibromatosis News and Research

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

Distinct genomic patterns of malignant peripheral nerve sheath tumors may help with early diagnosis

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

New study to investigate focused ultrasound's role in addressing neurofibromatosis type 2

Parents become drug developers to save their children’s lives

Epilepsy drug inhibits the growth of NF1 tumors in mice

Children’s National performs first-ever HIFU surgery on a pediatric patient with neurofibromatosis

Researchers discover why people with asthma have lower brain tumor risk

Studies outlines novel strategies for detecting cancer and minimal residual disease

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

New, one-stop method developed to avoid de novo genetic disease in embryos

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Antihypertension drug may benefit patients with neurofibromatosis type 2

Optic nerve activity may trigger the formation of vision-harming tumors in children

Sodium fluorescein may improve the safety and outcomes of vestibular schwannoma surgery

New drug reduces tumor volume and pain in patients with neurofibromatosis type 1

Researchers identify a compound that inhibits growth of schwannomas

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

The Incredible Potential of Lipid Nanoparticles (LNPs)

Hasret Altan-Martin

Speeding Up Sample Preparation to Accelerate Analytical Chemistry

Neuroscience eBook

Neurofibromatosis

Overview

Feature Articles

Neurofibromatosis Type 2

Neurofibromatosis Type 2 Causes and Diagnosis

Neurofibromatosis Type 2 Symptoms

Neurofibromatosis Type 2 Management

Von Recklinghausen Disease (Neurofibromatosis Type I)

Latest Neurofibromatosis News and Research

The Incredible Potential of Lipid Nanoparticles (LNPs)

Hasret Altan-Martin

Speeding Up Sample Preparation to Accelerate Analytical Chemistry

Neuroscience eBook

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