Pharmacology News and Research

Latest Pharmacology News and Research

DARPA grant supports research toward realizing tissue regeneration

While U.S. soldiers fighting in Iraq and Afghanistan are surviving injuries that in previous conflicts likely would have been fatal, the number of wounded with major tissue loss has never before been so high.

3 May 2006

Etanercept and chemo might reduce fatigue in cancer patients

Researchers here have found evidence that combining a drug typically used to treat rheumatoid arthritis with chemotherapy might help reduce fatigue and muscle wasting that often afflicts cancer patients.

3 May 2006

Tumour specific drugs may render therapies based on a tumor's anatomical location obsolete

The results of a new study at Washington University School of Medicine in St. Louis could eventually have oncologists removing their specialties from their shingles by making therapy based on a tumor's anatomical location obsolete.

28 Apr 2006

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study describes a new way to manipulate perhaps the most important signaling mechanism in human cells: G-protein coupled receptors (GPCRs).

28 Apr 2006

Research into toxins points to development of better medicines

Researchers have combined magnetic resonance spectroscopy with special protein synthesis procedures to uncover how potassium channels and toxins combine and change in structure. This work could make it possible to develop medications for high blood pressure and many other diseases connected to potassium channel failure .

23 Apr 2006

Antibiotics for exacerbations of chronic obstructive pulmonary disease

People with chronic obstructive pulmonary disease often experience short term worsening and aggravation of their symptoms.

18 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

An international research team has identified what may be a critical molecule in the ability of tumours to metastasize -- or spread -- into bone.

13 Apr 2006

Ingredient in red chili pepper has cancer-fighting properties

The study found that capsaicin, the "hot" ingredient in red chili pepper, caused pancreatic cancer cells to die through a process called apoptosis.

13 Apr 2006

U.S. watchdog says Xenical should be withdrawn

A consumer watchdog group in the U.S., Public Citizen, has petitioned the U.S. Food and Drug Administration (FDA) to withdraw the prescription diet drug Xenical (orlistat) from the market; the group also want the FDA to refuse approval for the weight-loss pill to be made widely available over the counter.

11 Apr 2006

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

St. John's wort and Echinacea, two widely-used herbal preparations, have been found to increase activity of a specific enzyme in the liver and intestine, an enzyme involved in the metabolization of roughly one in every four pharmaceutical drugs on the market today, reports a clinical pharmacologist at Indiana University School of Medicine.

11 Apr 2006

Caenorhabditis elegans helps unravel mechanisms of hunger

In research that may have implications for studying eating disorders in humans, a worm the size of a pinhead is helping researchers at UT Southwestern Medical Center unravel the mechanisms of hunger.

6 Apr 2006

Vegetables slow growth of prostate cancer in mice

Chemicals in cruciferous vegetables, such as broccoli, watercress, cabbage and cauliflower, appear to stop human prostate cancer cells from growing in mice by affecting the expression of proteins, says a University of Pittsburgh Cancer Institute study

6 Apr 2006

New mechanism that initiates metastasis

Researchers have known for years that the enzyme MMP-9 plays a key role in the spread of colorectal cancer. Now, scientists at Jefferson Medical College in Philadelphia have found out how the enzyme helps initiate the process, known as metastasis.

4 Apr 2006

Enzyme released by cardiac mast cells during heart attack contributes to arrhythmia

In times of cardiac crisis, mast cells in the heart secrete a powerful enzyme, renin, that indirectly triggers dangerous arrhythmias, according to a team of researchers at the Weill Medical College of Cornell University in New York City.

4 Apr 2006

Proteomics yields new drug targets for treating cardiogenic shock

When it comes to cell signaling and bioregulation, it's tough to find a more important molecule than nitric oxide (NO). Dysfunction of NO-mediated signaling is thought to be a culprit in lethal cardiovascular conditions such as angina, and septic, cardiogenic and hemorrhagic shock; it may play a role in many other illnesses as well.

3 Apr 2006