Pharmacology News and Research

Latest Pharmacology News and Research

Chink in cancer's armor

Much as the famed starship Enterprise would deploy a deflector shield to evade enemy attack, tumor cells are capable of switching on a molecular force field of their own to fend off treatments aimed at killing them. Now University of Florida researchers have found a chink in their armor.

13 Feb 2006

Gut protein protects against infection and intestinal breakdown

A protein that binds to bile in the small intestine may hold the key to preventing infection and intestinal breakdown in people with conditions such as obstructive jaundice or irritable bowel syndrome, researchers at UT Southwestern Medical Center have discovered.

12 Feb 2006

Study shows one third of candidates are unlikely to benefit from ICD

Last year, about 170,000 people in North America had devices surgically implanted to stop potentially fatal arrhythmias. For many, these were life-saving, but for others they were unnecessary, uncomfortable, and sometimes dangerous.

7 Feb 2006

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe-in real-time-the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions.

7 Feb 2006

Symposium on celiac disease

A scientific symposium on celiac disease, "Genetic and Immune Mechanisms in Celiac Disease," will be held at the University of California, San Diego (UCSD) School of Medicine on Friday, February 10, from 8:30 a.m. to 12 noon. The symposium, hosted by UCSD’s newly established William K. Warren Medical Research Center for Celiac Disease, will be held at the university’s Center for Molecular Genetics conference room.

23 Jan 2006

Gene therapy to turn off Parkinson's

A group of Northwestern University researchers is developing a novel gene therapy aimed at selectively turning off one of the genes involved in the development of Parkinson's disease.

23 Jan 2006

SSRI antidepressants may also affect human immune system

Drugs that treat depression by manipulating the neurotransmitter serotonin in the brain may also affect the user's immune system in ways that are not yet understood, say scientists from Georgetown University Medical Center and a Canadian research institute.

23 Jan 2006

Novel compound stops brain cell degeneration in Alzheimer's disease

Drug discovery researchers at Northwestern University have developed a novel orally administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated with Alzheimer's disease.

22 Jan 2006

More monitoring needed for patients taking diuretics

One in five patients taking diuretics commonly prescribed for high blood pressure or heart conditions end up with reduced sodium and potassium levels, according to a study published in the January issue of the British Journal of Clinical Pharmacology.

18 Jan 2006

Bugs in yoghurt may stop the spread of AIDS

Scientists have found that some of the 'friendly bacteria' found in yoghurt can be genetically modified to release a drug that blocks HIV infection.

18 Jan 2006

Researchers identify protein essential for the maintenance of synapses

Nerve cells store and transmit information via special contact sites called synapses. Synapses also play a role in determining what we remember and what we forget.

18 Jan 2006

Discovery of protein fragment that helps predict breast cancer outcome

Oregon Health & Science University Cancer Institute researchers have identified a protein fragment in some human breast cancers that may help predict a patient's chances of survival.

16 Jan 2006

Caffeine does it for female rats

According to recent research, something as simple as caffeine may be the female version of Viagra.

10 Jan 2006

DNA polymerase zeta gives cells with damaged DNA a new lease on life

Fortunately, our cells contain many enzymes devoted strictly to detecting and repairing any damage caused by these insults. In fact, failure of these enzymes to make needed repairs to genes can lead to the accumulation of mutations and, eventually, cell death or possibly cancer.

6 Jan 2006

Pharmacogenetics can reduce health care costs

Chances are good that a medication you take is one of several drugs that can be affected by genetic factors, according to researchers at Washington University School of Medicine in St. Louis and the St. Louis College of Pharmacy.

5 Jan 2006

Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive

Researchers at the University of Colorado at Denver and Health Sciences Center’s School of Medicine have uncovered how a gene linked to Parkinson’s disease can keep brain cells alive. The results suggest the possibility for new drugs that might regulate the gene and protect Parkinson’s patients from further cell damage.

29 Dec 2005

Study finds light sensing cells develop before vision

Investigators at Washington University School of Medicine in St. Louis have found that cells making up a non-visual system in the eye are in place and functioning long before the rods and cones that process light into vision.

22 Dec 2005

Microfluidics chips for simplifying medical imaging biomarkers of disease

A collaboration between scientists at UCLA, Caltech, Stanford, Siemens and Fluidigm have developed a new technology using integrated microfluidics chips for simplifying, lowering the cost and diversifying the types of molecules used to image the biology of disease with the medical imaging technology, Positron Emission Tomography (PET).

15 Dec 2005

Important skin color gene identified

With help from a common aquarium pet and a recently released online database of human genetic variation, a collaborative team of Penn State researchers has found what could be the most important skin color gene identified to date.

15 Dec 2005

Ack1 molecule stimulates the aggressive growth of prostate cancer

The molecule, Ack1, a member of the growth-promoting tyrosine kinase gene family, stimulates tumor formation in part by signaling prostate cells to rid themselves of a tumor-suppressor protein. Normally, this suppressor protein would inhibit rapid cell growth by signaling the cell to destroy itself.

5 Dec 2005