Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about ANZATAX Injection Concentrate (Paclitaxel).
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
ANZATAX against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What ANZATAX Injection Concentrate is used for
This medicine is used to treat:
non-small cell lung cancer (NSCLC).
This medicine/It belongs to a group of medicines called antineoplastic or cytotoxic
medicines. You may also hear of these being called chemotherapy medicines.
It works by killing cancer cells and stopping cancer cells from growing and multiplying.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
This medicine is not addictive.
This medicine is available only with a doctor's prescription.
There is not enough information to recommend the use of this medicine for children.
Before you are given ANZATAX Injection Concentrate
When you must not be given it
You must not be given ANZATAX if you have an allergy to:
any medicine containing paclitaxel or other medicines similar to paclitaxel called
any of the ingredients listed at the end of this leaflet.
any medicines containing PEG 35 castor oil, such as cyclosporin injection or teniposide
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
You must not be given this medicine if you have a very low white blood cell (WBC)
Tell your doctor if you have an infection or high temperature.
Your doctor may decide to delay your treatment until the infection has gone. A mild
illness, such as a cold, is not usually a reason to delay treatment.
You must not be given this medicine if you are pregnant or plan to become pregnant.
Like most cytotoxic medicines ANZATAX is not recommended for use during pregnancy.
If there is any need to consider this medicine during your pregnancy, your doctor
will discuss with you the benefits and risks of using it.
Males: tell your doctor if your partner plans to become pregnant while you are being
treated with this medicine or shortly after you have stopped treatment with it.
Male patients should seek advice regarding storage of sperm prior to treatment with
paclitaxel due to the possibility of infertility.
ANZATAX may cause birth defects if either the male or female is being treated with
it at the time of conception. It is recommended that you use some kind of birth control
while you are being treated with ANZATAX and for at least 12 weeks after you stop
using it. Your doctor will discuss this with you.
Do not breast-feed if you are taking this medicine.
The active ingredient in ANZATAX passes into breast milk and there is a possibility
that your baby may be affected.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you are given it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
any blood disorder with a reduced number of red blood cells, white blood cells, or
any disease of the nerves
lowered immunity due to diseases such as HIV/AIDS
lowered immunity due to treatment with medicines such as cyclosporin, or other medicines
used to treat cancer (including radiation therapy).
Or had a previous serious reaction to a similar drug to ANZATAX (called taxanes)
Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.
Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor about any of the above, tell him/her before you start
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and ANZATAX may interfere with each other. These include:
cisplatin and doxorubicin, medicines used to treat cancer
erythromycin, trimethoprim and rifampicin, antibiotics used to treat some bacterial
gemfibrozil, a medicine used to lower high cholesterol levels
deferasirox, a medicine used to treat iron overload
filgrastim, a medicine used for white blood cell disorders
fluoxetine, a medicine used to treat depression
carbamazepine, phenytoin and phenobarbital (phenobarbitone), medicines used for epilepsy
efavirenz and nevirapine, medicines used to treat HIV (Human Immunodeficiency Virus)
herbal medicines containing St John's wort.
These medicines may be affected by ANZATAX or may affect how well it works. You may
need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
How ANZATAX Injection Concentrate is given
How much is given
Your doctor will decide what dose of ANZATAX you will receive. This depends on your
condition and other factors, such as your weight, kidney function and other chemotherapy
medicines you are being given.
Before you are given ANZATAX, you must take some other medicines to prevent allergic
reactions occurring during your treatment.
You will need to take dexamethasone tablets 12 hours and 6 hours before your treatment,
which your doctor will prescribe for you. You will also be given 2 different injections
30 to 60 minutes prior to receiving ANZATAX. This will minimize the risk of allergic
ANZATAX may be given alone or in combination with other drugs.
Several courses of ANZATAX therapy may be needed depending on your response to treatment.
Additional treatment may not be repeated until your blood cell numbers return to acceptable
levels and any uncontrolled effects have been controlled.
Ask your doctor if you want to know more about the dose of ANZATAX you receive.
How it is given
ANZATAX is usually given as an infusion (drip) into a vein over 3 hours.
How long it will be given for
ANZATAX is usually given once every three weeks. Each infusion is called one ‘cycle’
of chemotherapy. Your doctor will decide how many of these cycles you will need.
If you take too much (overdose)
As ANZATAX is given to you under the supervision of your doctor, it is very unlikely
that you will receive too much. However, if you experience severe side effects after
being given this medicine, tell your doctor or nurse immediately.
You may need urgent medical attention.
Symptoms of an ANZATAX overdose include the side effects listed below in the ‘Side
Effects’ section, but are usually of a more severe nature.
If you experience severe side effects tell your doctor immediately, telephone your
doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to
Accident and Emergency at the nearest hospital.
You may need urgent medical attention.
While you are being given ANZATAX Injection Concentrate
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are being treated with ANZATAX.
Tell any other doctors, dentists, and pharmacists who are treating you that you are
being given this medicine.
If you are going to have surgery, tell the surgeon or anaesthetist that you are being
treated with this medicine.
It may affect other medicines used during surgery.
If you become pregnant while taking this medicine, tell your doctor immediately.
Keep follow-up appointments with your doctor.
It is important to have your follow-up cycles of ANZATAX at the appropriate times
to get the best effects from your treatments.
This medicine can lower the number of white blood cells and platelets in your blood.
This means that you have an increased chance of getting an infection or bleeding.
The following precautions should be taken to reduce your risk of infection or bleeding:
Avoid people who have infections. Check with your doctor immediately if you think
you may be getting an infection, or if you get a fever, chills, cough, hoarse throat,
lower back or side pain or find it painful or difficult to urinate.
Be careful when using a toothbrush, toothpick or dental floss. Your doctor, dentist,
nurse or pharmacist may recommend other ways to clean your teeth and gums. Check
with your doctor before having any dental work.
Be careful not to cut yourself when you are using sharp objects such as a razor or
Avoid contact sports or other situations where you may bruise or get injured.
Your body breaks down ANZATAX and uses it to fight cancer. The breakdown products
may be excreted in body fluids and waste, including blood, urine, faeces, vomitus
In general, precautions to protect other people should be taken while you are receiving
chemotherapy and for one week after the treatment period by:
Flushing the toilet twice to dispose of any body fluids and waste.
Wearing gloves to clean any spill of body fluid or waste. Use paper towels or old
rags, a strong solution of non-bleaching detergent and large amounts of water to mop
up the spill. Discard the towels or rags into a separate waste bag and dispose of
fluids in the toilet.
Wash linen or clothing that is heavily contaminated by body fluids or waste separately
from other items. Use a strong solution of non-bleaching detergent and large amounts
Place soiled disposable nappies and other pads in a plastic bag, seal and dispose
into the garbage.
For sexual intercourse, use a barrier method such as a condom.
Things to be careful of
Be careful driving or operating machinery until you know how ANZATAX affects you.
This medicine may cause dizziness or light-headedness in some people. If you have
these symptoms, do not drive, operate machinery or do anything else that could be
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are being given ANZATAX.
Like other medicines that treat cancer, ANZATAX may have unwanted side effects, some
of which may be serious. You may need medical treatment if you get some of the side
Do not be alarmed by the following lists of side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
muscle or joint pain on the arms and legs
nausea and vomiting
easily tiring during physical activity
indigestion, heartburn, diarrhoea or constipation
changes in skin or nail appearance
soreness or ulceration of the mouth.
irritation and inflammation of the mouth, throat, nose or vagina.
The above list may include the side effects of your medicine.
Tell your doctor as soon as possible if you notice any of the following:
pain, swelling, irritation and redness at the injection site
light-headedness or dizziness (due to low blood pressure)
headaches, confusion and memory problems
stinging pain, numbness or tingling in the fingers, toes and/or skin
redness, tightness, cracking, flaking or peeling of the skin
thick calluses and blisters on the palms of your hands and soles of your feet
difficulty walking or using your hands
changes in vision
The above list includes serious side effects that may require medical attention.
If any of the following happen, tell your doctor or nurse immediately, or if you are
not in hospital, go to Accident and Emergency at your nearest hospital:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue, or other parts of the body
rash, itching or hives on the skin
extreme weakness or tiredness
seizures (fits), fainting
fast, slow or irregular heartbeat
yellowing of the skin or eyes
unusual bleeding or bruising (including blood in your stools or urine)
fever, sore throat or other signs of infection.
The above list includes very serious side effects. You may need urgent medical attention
Tell your doctor, nurse or pharmacist if you notice anything that is making you feel
Other side effects not listed above may also occur in some people.
The benefits and side effects of ANZATAX may take some time to occur. Therefore, even
after you have finished receiving your treatment, you should tell your doctor immediately
if you notice any of the side effects listed in this section.
After being given ANZATAX Injection Concentrate
ANZATAX Injection Concentrate will be stored in the pharmacy or on the ward. The injection
is kept in a cool, dry place, protected from light, where the temperature stays below
What it looks like
ANZATAX Injection Concentrate is a clear to pale yellow solution, in a glass vial.
Each vial of ANZATAX Injection Concentrate contains 30 mg, 100mg, 150 mg or 300 mg
of paclitaxel as the active ingredient. It also contains:
PEG 35 castor oil
This medicine does not contain lactose, sucrose, gluten, tartrazine or any other azo
Pfizer Australia Pty Ltd
Sydney NSW 2000
Toll Free Number: 1800 675 229
ANZATAX Injection Concentrate is available in three strengths:
ANZATAX 30 mg/5 mL
AUST R 50578
ANZATAX 100 mg/16.7 mL AUST R 106458
ANZATAX 150 mg/25 mL AUST R 50577
ANZATAX 300 mg/50 mL
AUST R 91256
™ = Trademark
This leaflet was prepared in January 2023.