Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about DBL Carboplatin Injection. It does
not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
carboplatin against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What DBL Carboplatin Injection is used for
This medicine is used to treat:
cancer of the testes
some types of lung cancer
cancer of the brain and/or spinal cord
cancer of the head and neck
neuroblastoma (a cancer of the nerves and adrenal glands)
a type of cancer called sarcoma.
Carboplatin belongs to a group of medicines called antineoplastic or cytotoxic medicines.
You may also hear of these being called chemotherapy medicines. This medicine is classified
as a platinum-complex cytotoxic.
It works by killing cancer cells and/or stopping cancer cells from growing and multiplying.
DBL Carboplatin Injection is often used in combination with other medicines to treat
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another reason.
This medicine is not addictive.
This medicine is available only with a doctor's prescription.
Before you are given DBL Carboplatin Injection
When you must not be given it
You should not be given DBL Carboplatin Injection if you have an allergy to:
any medicine containing carboplatin
other platinum-containing compounds such as cisplatin or oxaliplatin
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
dizziness or light-headedness.
Females: Tell your doctor or pharmacist if you are pregnant or intend to become pregnant.
Like most cytotoxic medicines, carboplatin is not recommended for use during pregnancy.
Avoid becoming pregnant by using effective contraception during treatment and up to
6 months after therapy. If there is any need to consider carboplatin during your pregnancy,
your doctor or pharmacist will discuss the benefits and risks of using it.
Males: Tell your doctor or pharmacist if your partner intends to become pregnant while
you are being given DBL Carboplatin Injection, or shortly after you have stopped treatment
Carboplatin may cause birth defects if either the male or female is using it at the
time of conception. It is recommended that you use some kind of birth control while
you are using DBL Carboplatin Injection and for at least 12 weeks after you stop treatment.
A barrier method of birth control, such as a condom, should be used while you are
being given carboplatin and for the 12-week period after your last dose. Your doctor
will discuss this with you.
Do not breast-feed if you are taking this medicine.
It is not known whether carboplatin passes into breast milk and there is a possibility
that the breast-fed baby may be affected.
You must not be given this medicine if you have any of the following conditions:
very low numbers of white blood cells (WBC), red blood cells (RBC) or platelets
severe kidney problems (your dose may be reduced with some milder conditions)
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you are given it
Tell your doctor if you have allergies to any other medicines, foods, preservatives
Tell your doctor if you have or have had any of the following medical conditions:
condition of the blood with a reduced number of red blood cells, white blood cells,
bleeding problems or problems with blood clotting
problems with the nervous system such as numbness, tingling, weakness of limbs; headache,
seizures, confusion, vision disturbances
herpes zoster infections (also known as shingles)
chicken pox (now or recently), or if you have been in recent contact with someone
who has chicken pox.
Tell your doctor if you have had previous treatment with cisplatin.
Tell your doctor if you have an infection or high temperature.
Your doctor may decide to delay your treatment until the infection has gone. A mild
illness, such as a cold, is not usually a reason to delay treatment.
Tell your doctor if you are going to be vaccinated (have an injection to prevent a
If you have not told your doctor about any of the above, tell him/her before you are
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and carboplatin may interfere with each other. These include:
other medicines used to treat cancer (such as paclitaxel and cyclophosphamide), radiation
therapy or any other treatment which weakens your immune system
some antibiotics used to treat serious infections, including aminoglycosides (such
as gentamicin, tobramycin or amikacin)
some vaccines (ask your doctor)
These medicines may be affected by carboplatin or may affect how well it works. You
may need different amounts of your medicines, or you may need to take different medicines.
Do not have any vaccinations (immunisations) without your doctor’s approval while
you are being treated with DBL Carboplatin Injection, and for up to 12 months after
you stop treatment with it.
Carboplatin may lower your body’s resistance to infection and there is a chance that
you may get the infection the immunisation is meant to prevent.
In addition, other people living in your household should not take oral polio vaccine
(Sabin) since there is a chance they could pass the polio virus on to you.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking this medicine.
How DBL Carboplatin Injection is given
How much is given
Your doctor will decide what dose you will receive. This depends on your condition
and other factors, such as your weight, height, kidney function, blood counts and
other chemotherapy medicines you are being given.
DBL Carboplatin Injection may be given alone or in combination with other drugs.
Several courses of carboplatin therapy may be needed depending on your response to
Additional treatment may not be repeated until your blood cell numbers return to acceptable
levels and any unwanted effects have been controlled.
Ask your doctor if you want to know more about the dose of carboplatin you receive.
How it is given
DBL Carboplatin Injection is diluted in a fluid bag and then given as an infusion
(drip) into your veins, over 15 to 60 minutes. It must only be given by a doctor
How long it is given for
DBL Carboplatin Injection is usually given as a single infusion on one day. This
is called one ‘cycle’ of chemotherapy. A cycle is usually repeated 4 weeks after
the previous cycle. Your doctor will decide how many of these cycles you need.
If you receive too much (overdose)
As DBL Carboplatin Injection is given to you under the supervision of your doctor,
it is very unlikely that you will receive an overdose. However, if you experience
any severe side effects after being given DBL Carboplatin Injection, tell your doctor
immediately or go to Accident and Emergency at the nearest hospital.
In case of overdose, immediately contact the Poisons Information Centre for advice
(telephone 13 11 26 in Australia)
Symptoms of an overdose may include the side effects listed below in the ‘Side Effects’
section, but are usually of a more severe nature.
Ask your doctor, nurse or pharmacist if you have any concerns.
While you are being given DBL Carboplatin Injection
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are being given carboplatin.
Tell any other doctors, dentists, and pharmacists who treat you that you are being
given this medicine.
If you are going to have surgery, tell the surgeon or anaesthetist that you are being
given this medicine.
If you become pregnant while taking this medicine, tell your doctor immediately.
Keep all of your doctor's appointments so that your progress can be checked.
Your doctor may want to check your blood pressure and do some blood, hearing and other
tests from time to time to check on your progress and detect any unwanted side effects.
Keep follow up appointments with your doctor.
It is important to have your follow-up cycles of carboplatin at the appropriate times
to get the best effects from your treatments.
Carboplatin can lower the number of white blood cells and platelets in your blood.
This means that you have an increased chance of getting an infection or bleeding.
The following precautions should be taken to reduce your risk of infection or bleeding:
avoid people with infections. Check with your doctor immediately if you think you
are getting an infection, or if you get a fever or chills, cough or hoarseness, lower
back or side pain, or find it painful or difficult to urinate;
check with your doctor immediately if you notice any unusual bleeding or bruising,
black stools, blood in urine or stools or pinpoint red spots on your skin;
be careful when using a regular toothbrush, dental floss or toothpick. Your doctor
or nurse may recommend other ways to clean your teeth and gums. Check with your doctor
before having any dental work done;
be careful not to cut yourself when you are using sharp objects such as a safety razor
or nail cutters;
avoid contact sports or other situations where you may get bruised or injured
Carboplatin and its breakdown products may be excreted in body fluids and waste, including
blood, urine, faeces, vomitus and semen.
In general, precautions to protect other people should be taken while you are receiving
chemotherapy and for one week after the treatment period:
Flush the toilet twice to dispose of any body fluids and waste
Wear gloves to clean any spill of body fluid or waste. Use paper towels or old rags,
a strong solution of non-bleaching detergent and large amounts of water to mop up
the spill. Discard the towels or rags into a separate waste bag and dispose of fluids
in the toilet.
Wash linen or clothing that is heavily contaminated by body fluids or waste separately
from other items. Use a strong solution of non-bleaching detergent and large amounts
Place soiled disposable nappies and other pads in a plastic bag, seal and dispose
into the garbage.
For sexual intercourse, use a barrier method such as a condom.
While you are being given carboplatin, your doctor should order regular tests to check
the number of blood cells in your blood. The results of these tests will be used
to determine the amount of carboplatin you will be given for your next dose.
Things to be careful of
Be careful driving or operating machinery until you know how carboplatin affects you.
This medicine may cause dizziness, light-headedness, tiredness and drowsiness in some
people. If you have any of these symptoms, do not drive, operate machinery or do anything
else that could be dangerous.
Be careful when drinking alcohol while you are taking this medicine.
If you drink alcohol, dizziness or light-headedness may be worse.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are being treated with carboplatin.
Like other medicines, carboplatin may have unwanted side effects, some of which may
be serious. You may need medical attention if you get some of the side effects.
If you are over 65 years of age you may have an increased chance of getting side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
mild nausea or vomiting
diarrhoea or constipation
weakness, tiredness or fatigue
sore muscles or joints
pain or irritation at the injection site
The above list includes the more common side effects of your medicine. They are usually
mild and short-lived.
Temporary loss of hair, particularly that on the scalp is a less common but upsetting
side effect of carboplatin and occurs in a small number of patients (about 2 patients
per 100 treated). The severity of hair loss will depend on the dose of carboplatin
given. It is more common when other anti-cancer medicines are used together with
Tell your doctor or nurse as soon as possible if you notice any of the following:
muscle irritability or cramps
blurred vision or other visual disturbances
tingling in the fingers or toes
flaking or peeling of the skin, rash or itchy rash
The above list includes serious side effects that may require medical attention.
If any of the following happen, tell your doctor or nurse immediately or go to Accident
and Emergency at your nearest hospital:
signs of an allergic reaction (such as shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin; dizziness or light-headedness)
signs of infection, such as fever, chills, sore throat or mouth ulcers
headaches, changes in mental status (confusion, thinking abnormal, altered consciousness)
visual disturbances or loss
shortness of breath
rapid breathing or rapid heart rate
unusual bleeding or bruising, blood in urine or stools
problems with urination e.g. pain or difficulty
yellowing of the skin or eyeballs
severe nausea and vomiting
swollen face or limbs, abdominal pain or swelling
a feeling of tightness, pressure or heaviness in the chest.
The above list includes very serious side effects. You may need urgent medical attention
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Other side effects not listed above may also occur in some people.
Some of these side effects can only be found when your doctor does tests from time
to time to check your progress.
The benefits and side effects of carboplatin may take some time to occur. Therefore,
even after you have finished receiving your carboplatin treatment you should tell
your doctor immediately if you notice any of the side effects listed above.
After you have been given DBL Carboplatin Injection
DBL Carboplatin Injection will be stored in the pharmacy or on the ward. The injection
is kept in a cool dry place, protected from light, where the temperature stays below
What it looks like
DBL Carboplatin Injection is a concentrated colourless or slightly yellow solution
which will be diluted in a fluid bag and given as an infusion (‘drip’).
DBL Carboplatin Injection contains carboplatin as the active ingredient. It also
Water for Injection
This medicine does not contain lactose, sucrose, gluten, tartrazine or any other azo
Pfizer Australia Pty Ltd
Toll Free Number: 1800 675 229
DBL Carboplatin Injection is available in the following strengths and pack sizes:
50 mg in 5 mL, single glass
vials AUST R 12880
150 mg in 15 mL, single glass vials AUST R 46845
450 mg in 45 mL, single glass vials AUST R 46846
™ = Trademark
This leaflet was updated in August 2022.