Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about DBL Desferrioxamine Mesylate for
Injection BP (desferrioxamine mesilate).
It does not contain all the available information.
It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks
of you being given desferrioxamine mesilate against the benefits they expect it will
have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet in a safe place.
You may need to read it again.
What DBL Desferrioxamine Mesylate for Injection BP is used for
Desferrioxamine mesilate is a binding agent which is used to remove excess iron from
the body, thereby reducing damage that excess iron may cause. This may be necessary
after poisoning with iron containing medicines or in certain patients with anaemia
who receive many blood transfusions.
Desferrioxamine mesilate works by binding with the iron in the bloodstream. The bound
compound can then be removed from the body.
Your doctor may have prescribed desferrioxamine mesilate for another reason. Ask your
doctor if you have any questions about why this medicine has been prescribed for you.
Desferrioxamine mesilate is not addictive.
Desferrioxamine mesilate may be used in children but growth may be affected after
prolonged treatment. Ask your doctor for further information.
This medicine is available only with a doctor’s prescription.
Before you are given DBL Desferrioxamine Mesylate for Injection BP
When you must not be given it
You should not be given DBL Desferrioxamine Mesylate for Injection BP if you have
an allergy to desferrioxamine mesilate or any of the ingredients listed at the end
of this leaflet.
Symptoms of an allergic reaction to desferrioxamine mesilate may include:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin.
Desferrioxamine mesilate must not be given to you if you do not have any excess iron
stores. Your doctor will give you tests to confirm your iron levels.
You should not be given DBL Desferrioxamine Mesylate for Injection BP if you are pregnant
or intend to become pregnant.
Like most medicines, desferrioxamine mesilate is not recommended for use during pregnancy,
especially during the first three months, unless you and your doctor or pharmacist
have discussed the risks and benefits involved.
Do not give DBL Desferrioxamine Mesylate for Injection BP to children less than 2
to 3 years of age, unless directed by the child’s doctor.
You should not be given DBL Desferrioxamine Mesylate for Injection BP after the expiry
date (EXP) printed on the pack.
If you are given this medicine after the expiry date has passed, it may not work as
You should not be given DBL Desferrioxamine Mesylate for Injection BP if the packaging
is torn or shows signs of tampering.
If you are not sure whether you should start using DBL Desferrioxamine Mesylate for
Injection BP, talk to your doctor or pharmacist.
Before you are given it
Tell your doctor or pharmacist if you have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes
Tell your doctor if you are pregnant or intend to become pregnant.
Desferrioxamine mesilate may affect your developing baby if you are given it during
pregnancy. If it is necessary for you to be given desferrioxamine mesilate, your doctor
or pharmacist will discuss the risks and benefits of you being given it during pregnancy.
Tell your doctor or pharmacist if you are breast-feeding or plan to breast-feed.
It is not known whether desferrioxamine mesilate passes into breast milk.
Tell your doctor or pharmacist if you have or have had any medical conditions, especially
problems with urination, eg. kidney infection
kidney disease eg. you are receiving dialysis
sight or hearing problems
any heart conditions
the blood condition "thalassaemia"
signs of infection, such as fever, chills, stomach pain and/or sore throat
hyperparathyroidism (a condition resulting in excess calcium in the blood and problems
with the bones)
Tell your doctor or pharmacist if you are about to have any scans or x-rays.
Your doctor may recommend that you stop or delay your treatment with DBL Desferrioxamine
Mesylate for Injection BP, as it has the potential to interfere with certain scans.
If you have not told your doctor or pharmacist about any of the above, tell them before
you start treatment with DBL Desferrioxamine Mesylate for Injection BP.
If you are being given desferrioxamine mesilate for a prolonged period, you should
have sight and hearing tests and a test to confirm blood iron levels before treatment
If your doctor has told you that aluminium has affected your nerves, you may be given
the medicine clonazepam before you are given DBL Desferrioxamine Mesylate for Injection
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
Some medicines and desferrioxamine mesilate may interfere with each other. These include:
prochlorperazine; a drug sometimes used for nausea
any phenothiazines, medicines used mainly to correct chemical imbalance in the brain,
which may cause mental illness
methyldopa; a drug used to treat high blood pressure
vitamin C (ascorbic acid)
erythropoietin (used to treat anaemia)
These medicines may be affected by desferrioxamine mesilate or may affect how well
it works. You may need different amounts of your medicine, or you may need to take
different medicines. Your doctor or pharmacist will advise you.
Your doctor and pharmacist may have more information on medicines to be careful with
or avoid while you are being given desferrioxamine mesilate.
How DBL Desferrioxamine Mesylate for Injection BP is given
How much is given
Your doctor will decide what dose will receive. This depends on your condition and
other factors, such as your weight.
How it is given
DBL Desferrioxamine Mesylate for Injection BP may be given as an injection into a
muscle, under the skin or as a slow injection into a vein. It may also be given as
a slow infusion (eg. as a ‘drip’) into a vein or under the skin.
If you are on peritoneal dialysis, DBL Desferrioxamine Mesylate for Injection BP may
be administered as part of your peritoneal dialysis fluid which is injected into the
peritoneum (the membrane that lines the abdominal cavity and forms the outer coating
of the abdominal organs).
DBL Desferrioxamine Mesylate for Injection BP should only be given by a doctor, nurse
or other trained person.
DBL Desferrioxamine Mesylate for Injection BP is sometimes used for home infusions.
If it is to be used at home, you and your carers must be trained in its safe and appropriate
If you take too much (overdose)
As desferrioxamine is given to you under the supervision of your doctor, it is very
unlikely that you will receive too much.
Immediately telephone your doctor or the Poisons Information Centre (13 11 26) for
advice, or go to Accident and Emergency at the nearest hospital, if you think that
you or anyone else may have taken too much DBL Desferrioxamine Mesylate for Injection
BP. Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
While you are being given DBL Desferrioxamine Mesylate for Injection BP
Things you must do
Tell any other doctors, dentists, and pharmacists who are treating you that you are
being given desferrioxamine mesilate.
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are being given this medicine.
If you plan to have surgery that needs a general anaesthetic, tell your doctor or
dentist that you are being given this medicine.
If you become pregnant while being given desferrioxamine mesilate, tell your doctor
If you are being given desferrioxamine mesilate for a prolonged period, you should
have tests to assess the amount of iron in your urine every few weeks. Sight and hearing
tests should be repeated at three-month intervals.
If DBL Desferrioxamine Mesylate for Injection is given to children, it is recommended
that three-monthly checks on body weight and height are done by a doctor or nurse.
Things you must not do
Do not give your medicine to anyone else, even if they have the same condition as
DBL Desferrioxamine Mesylate for Injection BP should not be used to treat any other
complaints unless your doctor or pharmacist tells you so.
Avoid driving or operating machinery until you know how this medicine affects you.
As with some other medicines, desferrioxamine mesilate may cause dizziness, light-headedness
and visual or hearing disturbances in some people.
Make sure you know how you react to desferrioxamine mesilate before you drive a car,
operate machinery, or do anything else that could be dangerous if you are dizzy or
light-headed. If this occurs, do not drive.
Be careful when drinking alcohol while you are taking this medicine.
If you drink alcohol, dizziness or light-headedness may be worse.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are being given DBL Desferrioxamine Mesylate for Injection BP.
Desferrioxamine mesilate helps most people with too much iron in their blood, but
it may have unwanted side effects in a few people. All medicines can have side effects.
Sometimes they are serious, most of the time they are not. You may need medical treatment
if you get some of the side effects.
If you are over 65 years of age you may have an increased chance of getting side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
light-headedness or dizziness
pain, swelling or blisters at the injection site
urine changes to orange-rose colour
skin rash, itchiness
redness or flushing of the skin
loss of feeling in hands, feet, arms or legs, numbness or tingling (pins and needles).
aching joints and/or muscles.
These are the more common side effects of desferrioxamine mesilate. Mostly these are
mild and short-lived.
Tell your doctor or pharmacist if you notice anything of the following:
blurred vision or other problems with sight
nausea, vomiting or diarrhoea
abdominal or stomach cramps
problems with urination
bone pain, leg cramps or involuntary muscle contractions
signs of frequent infection, such as fever, chills, sore throat or mouth ulcers
unexplained or easy bruising, nosebleeds and bleeding gums, prolonged bleeding from
sudden swelling below or on the skin surface, or around the eyes, lips or throat.
These may be serious side effects. You may need urgent medical attention. Serious
side effects are rare.
Patients on dialysis may experience personality changes, headache, confusion, paralysis
of part or all of the body, stiff neck, abnormal, speech and eye movements.
If any of the following happen, tell your doctor or pharmacist immediately or go to
Accident and Emergency at your nearest hospital:
irregular heartbeat, chest pain
redness or flushing of skin, unusually cold hands and feet
shortness of breath, rapid breathing
blueish colouring of skin
asthma (bronchospasm or tightness of chest with wheezing or coughing and difficulty
These are very serious side effects. You may need urgent medical attention or hospitalisation.
If you start to feel feverish with a sore throat or stomach pains, or general discomfort
or develop shortness of breath while you are taking DBL Desferrioxamine Mesylate for
Injection BP, you must seek medical advice immediately.
This is because people who have iron or aluminium overload are more vulnerable to
certain types of infection.
If you get an infection, your doctor may want you to do some tests and give you some
medicines to treat the infection. Your doctor may also have you stop using DBL Desferrioxamine
Mesylate for Injection BP until any infections clear up.
Tell your doctor or pharmacist if you notice anything that is making you feel unwell.
Other side effects not listed above may occur in some patients.
After you have been given DBL Desferrioxamine Mesylate for Injection BP
DBL Desferrioxamine Mesylate for Injection should be stored in a cool dry place, protected
from light, where the temperature stays below 25C.
If your doctor tells you to stop taking this medicine or the expiry date has passed,
ask your pharmacist what to do with any medicine that is left over.
What it looks like
DBL Desferrioxamine Mesylate for Injection BP is a white powder. It should be completely
dissolved in Water for Injections before use, to produce a clear solution.
There are no other ingredients.
DBL Desferrioxamine Mesylate for Injection BP does not contain lactose, sucrose, gluten,
tartrazine or any other azo dyes.
Pfizer Australia Pty Ltd
Toll Free Number: 1800 675 229
DBL Desferrioxamine Mesylate for Injection BP is available in the following strengths:
500 mg/vial (AUST R 53942).
2 g/vial (AUST R 73173).
Date of leaflet preparation - January 2023.
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© Pfizer Australia Pty Ltd (2023)