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Discovering distinct gut-brain pathways for sugars and fats

Researchers identify independent vagal sensing pathways for fat and sugar detection.

23 Jan 2024

Study identifies genetic variants that influence response to preterm birth treatment

A UC San Francisco-led study has for the first time identified genetic variants that predict whether patients will respond to treatment for preterm birth, a condition that affects one in 10 infants born in the United States.

22 Jan 2024

Moffitt researchers develop novel reagent for efficient synthesis of sulfur-containing drug candidates

During the past decade, there has been significant development of new sulfur containing compounds that are used in various industries, including pharmaceuticals and agricultural products.

22 Jan 2024

Study highlights the complex genetic landscape that drives modern tardigrade ecology

Tardigrades may be nature's ultimate survivors. While these tiny, nearly translucent animals are easily overlooked, they represent a diverse group that has successfully colonized freshwater, marine, and terrestrial environments on every continent, including Antarctica.

22 Jan 2024

Scientists demonstrate way to produce SARS-CoV-2 receptor protein in mouse cells

A team of scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Columbia University has demonstrated a way to produce large quantities of the receptor that SARS-CoV-2, the virus that causes COVID-19, binds to on the surface of human cells.

22 Jan 2024

RecA protein skips "unwinding" step in DNA repair

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

20 Jan 2024

CRISPR off-switch discovered: Safer gene editing for future therapies

Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells.

19 Jan 2024

New instruction manual could help scientists find hard-to-detect B cells

Researchers with McMaster University have created the instruction manual that will help scientists across the globe find hard-to-detect B cells.

19 Jan 2024

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications journal focusing on critical studies about molecular structure and biological activity, has published the company's discovery of a novel PHD inhibitor for the treatment of anemia.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

New structural insights pave the way for drug-resistant malaria therapies

Structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers at Weill Cornell Medicine and Van Andel Institute.

18 Jan 2024

Monell study: Unraveling the brain's wiring for fat and sugar cravings

Understanding why we overeat unhealthy foods has been a long-standing mystery. While we know food's strong power influences our choices, the precise circuitry in our brains behind this is unclear.

18 Jan 2024

Uncovering the cellular roots of spinocerebellar ataxia type 6

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

18 Jan 2024

DNA origami used to unveil novel Notch receptor activation pathway

Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way.

18 Jan 2024

New targeted therapy eliminates cancer with zero side effects

Johannes Karges develops anti-cancer agents that work in a targeted manner, rather than adversely affecting the entire body.

18 Jan 2024

New technique provides an unprecedented view inside the cell's control center

The cell nucleus is considered to be the control center of vital cellular processes, but its material properties continue to puzzle scientists.

18 Jan 2024

Lab-grown mini-placentas shed light on pre-eclampsia and pregnancy disorders

Scientists have grown 'mini-placentas' in the lab and used them to shed light on how the placenta develops and interacts with the inner lining of the womb – findings that could help scientists better understand and, in future, potentially treat pre-eclampsia.

17 Jan 2024

New, automated shake and fire platforms from Copley cut the burden of MDI and nasal drug product testing.

The latest generation of Vertus® automated shake and fire platforms from Copley Scientific make it easy and intuitive to integrate automation into a wide range of drug product testing workflows to boost productivity, drive down test variability, and simplify training.

From Copley Scientific Limited 17 Jan 2024

Researchers uncover the role of inherited genetic variants in rare type of blood cancer

Large-scale genetic analysis has helped researchers uncover the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer.

17 Jan 2024

New USC study reveals how DNA loops silence gene activity

The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be condensed to fit inside the nucleus. DNA condensation is not random.

16 Jan 2024