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Gene therapy for rare diseases: A decade of progress and remaining challenges

A new review article in the peer-reviewed journal Human Gene Therapy summarizes the significant milestones in the development of gene therapy medicinal products that have facilitated the treatment of a significant number of rare diseases.

14 Nov 2023

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as likely to relapse and three times as likely to die within five years of diagnosis.

14 Nov 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Study demonstrates the use of cellulose nanofiber sheets for spatial analysis of extracellular vesicles, revealing their geographical heterogeneity in the human body, which could advance the understanding and treatment of diseases.

14 Nov 2023

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

The COVID-19 disease, due to infection with the SARS-CoV2 virus, became an international pandemic in 2020. To date, more than 770 million people have suffered from the disease and nearly 7 million of them have lost their life.

14 Nov 2023

Traffic emissions disrupt gene expression in human olfactory cells

Exposure to ultrafine particles from traffic alters the expression of many genes in human olfactory mucosa cells, a new study shows.

14 Nov 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

14 Nov 2023

Genetic test for antidepressants could save millions and improve patient outcomes

A special kind of genetic test that helps determine the best antidepressant for patients with moderate-to-severe depression could generate substantive health system savings and greatly improve patient outcomes, according to new research from the University of British Columbia.

14 Nov 2023

Introducing Luminescence 96: A Groundbreaking Advancement in Luminescence-Based Assays

With a vision to reenvision the lab and a passion for simplifying laboratory workflows with highly intuitive and functional designs, Byonoy launches Luminescence 96, further expanding its range of high-quality plate readers.

From Byonoy 14 Nov 2023

Neural circuits respond to rapid dopamine surges

Researchers assess the pharmacodynamics of dopamine signaling, brain connectivity/activity, and self-documented 'high' following methylphenidate exposure.v

14 Nov 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

13 Nov 2023

New physical mechanism uncovered for breast cancer invasion

The majority of breast cancers start in the lining of a breast milk duct and, if they remain there, are very treatable.

13 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

ATCC announces award from national institute of allergy and infectious diseases to support its preclinical services for biopharmaceutical product development

ATCC today announced that it has been awarded an Indefinite Delivery/Indefinite Quantity (IDIQ) contract.

From ATCC 13 Nov 2023

NanoSyrinx appoints Anthony Johnson as Non-Executive Director

Appointment of Big Pharma executive strengthens leadership team to drive ambitious growth strategy.

From NanoSyrinx 13 Nov 2023

BioEcho introduces EchoLUTION™ FFPE RNA Kit for superior RNA extraction from FFPE tissues

A leading provider of innovative molecular biology solutions, announces the launch of its EchoLUTION FFPE RNA Kit.

From BioEcho Life Sciences GmbH 13 Nov 2023

New hope for TB patients as UNITE4TB launches clinical trial program

Today, UNITE4TB, an international public-private partnership striving to fast-track the development of innovative Tuberculosis (TB) treatments, announced the start of its phase 2B/C clinical trial program with the first participant enrolled at its trial site in Cape Town, South Africa.

13 Nov 2023

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM.

13 Nov 2023

UCI researchers discover gene critical for muscle repair

University of California, Irvine researchers have identified a gene expressed during regeneration that is critical for muscle repair.

12 Nov 2023

Researchers identify key factors involved in DNA repair mechanism

Researchers from Tokyo Metropolitan University have identified key factors in the mechanism behind DNA repair in our bodies.

12 Nov 2023

Life Science News

Gene therapy for rare diseases: A decade of progress and remaining challenges

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

Traffic emissions disrupt gene expression in human olfactory cells

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Genetic test for antidepressants could save millions and improve patient outcomes

Introducing Luminescence 96: A Groundbreaking Advancement in Luminescence-Based Assays

Neural circuits respond to rapid dopamine surges

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

New physical mechanism uncovered for breast cancer invasion

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

ATCC announces award from national institute of allergy and infectious diseases to support its preclinical services for biopharmaceutical product development

NanoSyrinx appoints Anthony Johnson as Non-Executive Director

BioEcho introduces EchoLUTION™ FFPE RNA Kit for superior RNA extraction from FFPE tissues

New hope for TB patients as UNITE4TB launches clinical trial program

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

UCI researchers discover gene critical for muscle repair

Researchers identify key factors involved in DNA repair mechanism

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