Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Preclinical Brain Imaging: The use of dMRI

Preclinical Brain Imaging: The use of dMRI

The use of magnetic resonance imaging (MRI) with diffusion-based strategies (dMRI) may be helpful for understanding neuronal connectivity, mainly via estimation and direct examination of specific water patterns into living tissue.

From Bruker BioSpin - NMR, EPR and Imaging 12 Sep 2018

Explaining the Use of Ripa Buffer for Lysate Preparation in Western Blot

Explaining the Use of Ripa Buffer for Lysate Preparation in Western Blot

When all requirements are considered, the automatic choice for lysate preparation is RIPA buffer.

From Proteintech Group, Inc 6 Sep 2018

Using MMS to Structurally Characterize Insulin-Degrading Enzymes

Using MMS to Structurally Characterize Insulin-Degrading Enzymes

The ubiquitously expressed Zn2+ metalloprotease Insulin-degrading enzyme (IDE) digests several key substrates, such as glucagon, insulin, amylin, and amyloid-b.

From RedShiftBio 3 Aug 2018

Microfluidic Modulation Spectroscopy - Detecting Early Events in Amyloid Formation

Microfluidic Modulation Spectroscopy - Detecting Early Events in Amyloid Formation

Systemic amyloidosis, a disease characterized by the presence of amyloid deposits in various organs of the body, is related with the self-assembly of lysozyme to form amyloid fibrils.

From RedShiftBio 3 Aug 2018

Removing Peptides

Removing Peptides

In a Fmoc synthetic approach, the detachment of the peptide from its solid support is usually achieved by using trifluoroacetic acid (TFA).

From CEM Corporation - Life Science 5 Sep 2018

Enabling Side-Chain Branching, Bioconjugation and Cyclization with the Liberty Blue

Enabling Side-Chain Branching, Bioconjugation and Cyclization with the Liberty Blue

The Liberty Blue™ can automatically undertake the deprotection of orthogonal and non-standard side-chain protecting groups, allow side-chain branching, bioconjugation and cyclization.

From CEM Corporation - Life Science 5 Sep 2018

Peptide Coupling at Elevated Temperatures

Peptide Coupling at Elevated Temperatures

CarboMAX is a novel patented coupling method for the synthesis of peptide using elevated temperatures. It provides an improvement against existing carbodiimide methods by utilizing a quicker activation and subsequent reduction in epimerization.

From CEM Corporation - Life Science 5 Sep 2018

Using Microwave Assisted Metathesis with Hydrocarbon-Stapled Peptides

Using Microwave Assisted Metathesis with Hydrocarbon-Stapled Peptides

Hydrocarbon-stapled peptides can be quickly synthesized with a high purity via microwave enhanced SPPS on the Liberty Blue™ automated microwave peptide synthesizer.

From CEM Corporation - Life Science 5 Sep 2018

Synthesising Phosphopeptides

Synthesising Phosphopeptides

A highly effective synthetic approach to realize difficult phosphopeptides is demonstrated using the Liberty Blue™ automated microwave peptide synthesizer, alongside CarboMAX™ coupling methods.

From CEM Corporation - Life Science 5 Sep 2018

Using Microwave Assisted SPPS for Difficult Non-Standard Amino Acids

Using Microwave Assisted SPPS for Difficult Non-Standard Amino Acids

Hindered, non-standard amino acids, including α-aminoisobutyric acid (Aib) and N-methyl alanine ((N-Me)-A) (Figure 1) are present in many biologically relevant molecules.

From CEM Corporation - Life Science 5 Sep 2018

Synthesizing Peptoids and Peptide-Peptoid Hybrids

Synthesizing Peptoids and Peptide-Peptoid Hybrids

Peptoids are a type of polymer which are composed of different N-substituted glycines. Even though they are similar in structure to peptides (Figure 1), peptoids are resistant to proteolytic degradation, which is due to the full substitution of their amide linkages.

From CEM Corporation - Life Science 5 Sep 2018

The Benefits of Microwave Chemistry

The Benefits of Microwave Chemistry

Microwave heating can be used for many types of synthetic transformation, such as the assembly of nanomaterials, polymerization reactions, and in the synthesis of small molecule.

From CEM Corporation - Life Science 5 Sep 2018

Modifying Conventional Heating Protocols with Microwave-Assisted Heck Reaction

Modifying Conventional Heating Protocols with Microwave-Assisted Heck Reaction

Almost all standard heating synthetic transformation reactions can be modified for use with microwave heating.

From CEM Corporation - Life Science 5 Sep 2018

Analyzing Microwave-Assisted Synthesis of Acetaminophen in Two Steps

Analyzing Microwave-Assisted Synthesis of Acetaminophen in Two Steps

Almost all synthetic approaches can utilize the benefits of microwave heating, such as seeing a decrease in the reaction times, a lower amount of waste, and a purer product.

From CEM Corporation - Life Science 5 Sep 2018

Using Preclinical MRI to Image White Matter Injury

Using Preclinical MRI to Image White Matter Injury

In pediatric patients with complex or severe congenital heart disease undergoing severe or cardiopulmonary bypass (CPB), there is a high risk for post-surgical newly developed white matter injury.

From Bruker BioSpin - NMR, EPR and Imaging 4 Sep 2018

Spectra of Trans-Ethyl Crotonate

Spectra of Trans-Ethyl Crotonate

Aroma products generally contain ethyl crotonate, trans-(ethyl but-2-enoate) as one of their components. A clear, colorless liquid with a pungent odor, this organic compound is highly flammable and does not dissolve in water.

From Anasazi Instruments, Inc. 4 Sep 2018

Why it is Important to Reduce Errors in NMR Spectroscopy

Why it is Important to Reduce Errors in NMR Spectroscopy

NMR spectroscopy can be performed with great accuracy, but can only be achieved if a number of sources of error are handled correctly.

From Anasazi Instruments, Inc. 4 Sep 2018

Using Dow704 Diffusion Pump Oil for Research and Production Applications

Using Dow704 Diffusion Pump Oil for Research and Production Applications

Dow704 diffusion pump oil (tetramethyl tetraphenyl trisiloxane) is used in large and medium diffusion pumps for a wide range of research and production applications, as the lower attainable pressure rationalizes the expense of this excellent fluid.

From Anasazi Instruments, Inc. 4 Sep 2018

Using Raman Spectroscopy for Probing Indentation-Induced Structural Changes

Using Raman Spectroscopy for Probing Indentation-Induced Structural Changes

The detection of various polymorphs of drug materials is crucial in the pharmaceutical industry since any variations in the structure or composition might result in a different clinical response.

From Bruker Nano Surfaces 6 Jul 2018

Using Autoclaves for Sterilization and Strength

Using Autoclaves for Sterilization and Strength

Autoclaves are used to sanitize and sterilize a range of materials by working with a combination of pressure, steam, and time.

From MadgeTech, Inc 3 Sep 2018

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Purifying Proteins from Mammalian Cell Culture

Dennis Karthaus, MSc

In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function of the therapeutic protein.

Purifying Proteins from Mammalian Cell Culture

It’s About TIME: Raising Awareness of Sepsis

Dr. Steven Simpson

An interview with Dr. Steven Simpson, MD, discussing the importance of raising awareness of the signs and symptoms of sepsis, and how Sepsis Alliance is helping to reduce the number of deaths caused by sepsis in the USA.

It’s About TIME: Raising Awareness of Sepsis

Mimicking Human Brain Development Using Organoids

Dr. Paul Tesar

Dr. Paul Tesar from the Tesar Laboratory at Case Western University, Ohio, discusses the importance of organoids in biological research and the development of organoids which are capable of simulating the early stages of human myelin.

Mimicking Human Brain Development Using Organoids