Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Combining Electron Paramagnetic Resonance and Atomic Force Microscopy to Elucidate Oxidative Stress in Eye Disorders

Oxidative damage is thought to underlie many age-related disorders of the eye, and can be caused by oxidative molecules as well as photooxidation from UV light. The risk of AMD increases with exposure to light, highlighting the detrimental potential of oxidation to the aging eye.

From Bruker BioSpin - NMR, EPR and Imaging 5 Sep 2017

An Overview of Proton Detection in Biological Samples under Ultra-Fast Magic Angle Spinning

Attributes like natural abundance of over 99.9% and a high gyromagnetic ratio help in the characterization of protons. Thanks to these attributes, a greater detection sensitivity than those of 15N or 13C is obtained which makes 1H-detected NMR spectroscopy extremely attractive, and not only for solution NMR.[1-6]

From Bruker BioSpin - NMR, EPR and Imaging 31 Aug 2017

Using TD-NMR Analysis for Fast and Reliable Quality Control for Toothpaste Production

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From Bruker BioSpin - NMR, EPR and Imaging 31 Aug 2017

Analysis of Gadolinium-Based MRI Contrast Agents using IC-ICP/MS Technique

Gadolinium contrast agents, which are mainly administered via intravenous injection, exhibit excellent in vitro and in vivo stability. These agents have a half-life of about two hours. They are excreted from the body unchanged via the kidney-urine pathway and passed into wastewater.

From Metrohm NA 31 Aug 2017

Electron Paramagnetic Resonance Aids Cancer Drug Development

Chromosome instability is a key hallmark of cancers, increasing mutation rates and helping tumor cells evade destruction by the immune system as well as treatment by medical interventions. Hypoxia contributes to this instability, causing replication stress and a subsequent loss of the cellular machinery required to deal with DNA damage.

From Bruker BioSpin - NMR, EPR and Imaging 30 Aug 2017

Nuclear Magnetic Resonance Helps Researchers Improve Drug Delivery

Modern medicine has evolved rapidly over the past century, and the development of safe and effective drugs has been a key factor in reducing death and disability from diseases which were once a death sentence. Advances in vaccination led to the complete elimination of small pox by 1990, and as of 2016, polio cases have been reduced by 99% worldwide as well.1,2 Pharmacological agents, such as statins, chemotherapeutics, and anti-retroviral therapies have made incredible progress in treating heart disease, cancer, and HIV/AIDS.

From Bruker BioSpin - NMR, EPR and Imaging 24 Aug 2017

Efficient Solution for Automated TruSight HLA v2 Sequencing Panel Library Preparation

Tecan’s TouchTools™ software interface assists the operator in library preparation and instrument set-up, thus creating highly reproducible, sequencing-ready libraries through minimized training and reduced operator-to-operator variability.

From Tecan 14 Jun 2017

GoTaq® MDx Hot Start Polymerase: A General Purpose Reagent for Molecular Diagnostic Assays

Many PCR-based molecular diagnostic tests utilize a hot-start thermostable DNA polymerase. The hot start polymerase format of these Taq DNA polymerase products are preferred because of their ability improve the specificity of the amplification assay by reducing non-specific amplification.

From Promega Corporation 21 Aug 2017

Using Online NMR Reaction Monitoring to Understand Mechanisms and Kinetics of Chemical Reactions

Nuclear magnetic resonance (NMR) is a structurally rich and non-intrusive technique that is quantitative by nature. These inherent characteristics make NMR extremely robust for identifying and characterizing reaction intermediates, thus allowing a better understanding about the kinetics of chemical reactions and reaction mechanisms.

From Bruker BioSpin - NMR, EPR and Imaging 18 Aug 2017

Adopting a Best-in-Class Strategy for Digital Pathology

Five years ago, my wife and I renovated our kitchen. We envisioned a unified look, but it wasn’t critical that all the appliances were from the same manufacturer – they just had to look and work well together. Through our selection process, numerous suppliers offered specials if we bought multiple appliances from the same manufacturer.

From Huron Digital Pathology 9 Aug 2017

Using Cryogenic Grinding for RNA Extraction from Cartilage Tissue

This article aims to find out whether a relationship exists between the severity of arthritic disorders, particularly between certain genes and the knee joint. As such, comparison was made between the expression profile of a variety of genes present in the tissue of diseased and healthy probands.

From SPEX SamplePrep 16 Aug 2017

Using Geno/Grinder® for High Throughput Yeast Disruption in a Microwell Format

Traditionally, either a press mill or bead mill (i.e., bead beater) was used to mechanically cause yeast disruption in the cells. In both these methods, samples are individually processed posing a major bottleneck for experiments where many numbers of yeast clones have to be analyzed in a high throughput screening environment.

From SPEX SamplePrep 16 Aug 2017

Using Geno/Grinder for Lysing Bacterial Cells

The Geno/Grinder technology was tested to find out whether it can be used for lysing bacterial cells. Regular 96-well titer plates were utilized with 400 to 600μ silica grinding beads (Molecular Biology Grade, cat. no. 2166) to lyse the cells.

From SPEX SamplePrep 16 Aug 2017

Could fragment-based screening using NMR tackle antibiotic resistance?

With antibiotic resistance continuing to gain pace globally, there is increasing need for fresh approaches in drug discovery to avoid a future in which deaths from previously preventable infections are common.

From Bruker BioSpin - NMR, EPR and Imaging 15 Aug 2017

Solid Fat Content Determination by Time Domain (TD) NMR Analysis

Determining solid fat content (SFC) is important in the processing and development of food products. It is essential to characterize and control raw materials like fat compositions or blends in accordance with their melting profiles.

From Bruker BioSpin - NMR, EPR and Imaging 11 Aug 2017

Nuclear Magnetic Resonance Reveals New Drug Compounds

In 1971 President Nixon declared a “war on cancer”, when signing the National Cancer Act into US law.1 Since then, researchers, funding agencies, outreach groups, and clinicians have made great progress towards eradicating this devastating set of diseases.

From Bruker BioSpin - NMR, EPR and Imaging 10 Aug 2017

Using EPA 300 Method for Determination of Anions in Tap Water

In the US, the Maximum Contamination Levels (MCL) in drinking water are established by the Environmental Protection Agency (EPA) through the Safe Drinking Water Act (SDWA). The EPA also controls industrial discharge MCL through the Clean Water Act (CWA).

From Metrohm NA 9 Aug 2017

Trends and Developments of Ion Chromatography in Pharmaceutical Analysis

As a highly flexible technique, ion chromatography (IC) has many practical applications in the pharmaceutical field. This article reviews some relevant trends and recent developments in IC application.

From Metrohm NA 9 Aug 2017

On-Field Determination of Arsenic, Mercury, and Copper in Ground Water

Mercury and arsenic are examples of heavy metals that can be found in ground water across many parts of the world. These metals reach the ground water either as a result of human activities or through natural processes. In a number of regions, the limit values for the concentrations of these metals are exceeded by many times, especially in the case of arsenic found in drinking water.

From Metrohm NA 9 Aug 2017

Determination of Glyphosate and AMPA in Drinking Water Using Ion Chromatography with Pulsed Amperometric Detection

Glyphosate is a broad-spectrum herbicide that is widely used in agriculture across the globe. The chemical is also used as a weed killer in domestic gardens, as well as in private and public spaces such as railway tracks, to prevent vegetal invasion. Since the 1970s, glyphosate has been used in pesticides and until now, it was believed to be safe at usual levels of exposure.

From Metrohm NA 9 Aug 2017