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Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Scientists create new compliance-based model for SARS-CoV-2 transmission

Researchers from Utrecht University have been investigating the interactions between compliance social distance measurements, infection, and vaccination coverage in order to inform public health policy further. A research paper covering their work is available on the medRxiv* preprint server.

28 Sep 2021

Super-resolution imaging and size analysis of SARS-CoV-2 virus particles

Researchers from the University of Oxford and the University of Warwick have collaborated to develop a method to better understand and evaluate these pleiomorphisms.

28 Sep 2021

Study shows link between smoking and COVID-19 severity, death

Smoking is highly likely to worsen the severity of COVID-19 and the risk of dying from the infection, finds a large UK Biobank study published online in the respiratory journal Thorax.

28 Sep 2021

Novel optogenetic implant controls activity of neurons in the spinal cord

Grégoire Courtine doesn't hesitate to use the word "revolutionary" when describing the emerging field of optogenetics – a technology that uses pulses of light to control individual neural activity – and what it could mean for neuroscience. Courtine, director of the NeuroRestore research center (with neurosurgeon Jocelyne Bloch), is currently developing an optogenetic implant together with Stéphanie Lacour, who holds the Bertarelli Foundation Chair in Neuroprosthetic Technology.

28 Sep 2021

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

It has been demonstrated in recent studies that there is a significant breadth of emerging autoreactivity associated with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. More specifically, researchers from Emory University have identified a relaxation of peripheral tolerance within early antibody secretion cells that arise in individuals infected with SARS-CoV-2, as important drivers of those responses.

28 Sep 2021

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the criteria for graduation to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

28 Sep 2021

Researchers release guidance to address pathology aspects in clinical trial protocols

An international group of cancer researchers, led by the National Cancer Research Institute's (NCRI) Cellular Molecular Pathology Initiative (CMPath), has published guidance to address the variability in how pathology is planned and delivered in clinical trials.

28 Sep 2021

COVID-19 lockdown linked with important changes in people's thought patterns

Prolonged social isolation and changes to work opportunities during the first UK lockdown were linked with important changes in people's thought patterns, a new study suggests.

28 Sep 2021

Study maps hotspots of low-value care use at individual health systems

Researchers estimate that up to $101 billion in health care spending is wasted each year due to over-treatment or the delivery of "low-value care." Low-value care includes a wide array of tests and treatments that are medically unnecessary and for which the potential for harm outweigh the potential for benefit. While researchers have charted the ongoing use of low-value care on national and regional levels, little research exists on how health systems across the country use low-value care and how they compare to each other.

28 Sep 2021

China's declining birth rates and aging population may not hinder future prosperity

New research on China suggests that declining birth rates and an aging population might not hinder future prosperity when associated with better education of the young.

28 Sep 2021

Researchers develop fast, low-energy artificial synapse for advanced AI systems

Brain-inspired computing is a promising candidate for next-generation computing technologies. Developing next-generation advanced artificial intelligence (AI) systems that can be as energy-efficient, lightweight, and adaptable as the human brain has attracted significant interest.

28 Sep 2021

Risk factors associated with in-school transmission of SARS-CoV-2

As schools resume in the United States and COVID-19 cases amongst children begin to rise, a new study published on the medRxiv* preprint server has highlighted the risk factors for in-school transmission of COVID-19. They also provide evidential support for the layered prevention strategies in schools settings.

28 Sep 2021

COVID Moonshot receives key funding to accelerate drug discovery efforts

The COVID Moonshot, a non-profit, open-science consortium of scientists from around the world dedicated to the discovery of globally affordable and easily-manufactured antiviral drugs against COVID-19 and future viral pandemics has received key funding of £8 million from Wellcome, on behalf of the Covid-19 Therapeutics Accelerator.

28 Sep 2021

Confinement drastically reduced the transmission of COVID-19 variants in Spain during first wave

The most complete studies on the variants of the coronavirus that dominated the first waves in Spain have just been published in Nature Genetics. The study was carried out by the SeqCOVID consortium, which includes more than 50 Spanish institutions led by the University of Valencia, the Institute of Biomedicine of Valencia (IBV, CSIC), and the Fisabio Foundation.

28 Sep 2021

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

A team of scientists from China and the USA has recently described the antiviral efficacy of a monoclonal antibody candidate targeting the spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Importantly, they have observed that emerging spike mutations could not affect the potency of this antibody. The study is currently available on the bioRxiv* preprint server.

27 Sep 2021

Most adults prefer monitoring blood pressure at home, research finds

Adults who needed to track their blood pressure regularly to confirm or refute a hypertension diagnosis preferred monitoring blood pressure at home versus at a clinic, kiosk or with a 24-hour wearable device, according to preliminary research presented today at the American Heart Association's Hypertension Scientific Sessions 2021.

27 Sep 2021

New discovery greatly improves detection of HPV in the bloodstream

Princess Margaret Cancer Centre researchers have made new findings which greatly improve detection of the human papillomavirus (HPV) in the bloodstream and could further hone precision treatment of the illness.

27 Sep 2021

Pfizer-BioNTech’s COVID-19 vaccine appears effective against SARS-CoV-2 mu variant

Researchers in Japan have conducted a study showing that the vaccine developed by Pfizer-BioNTech to protect against coronavirus disease 2019 (COVID-19) seems to be adequately effective against the B.1.621 (mu) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Sep 2021

Solar exposure guidelines for optimal vitamin D synthesis may need to be revised, study suggests

Previously published solar exposure guidelines for optimal vitamin D synthesis based on a study of skin samples may need to be revised, according to new research published today in PNAS.

27 Sep 2021

Medical News

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

Scientists create new compliance-based model for SARS-CoV-2 transmission

Super-resolution imaging and size analysis of SARS-CoV-2 virus particles

Study shows link between smoking and COVID-19 severity, death

Novel optogenetic implant controls activity of neurons in the spinal cord

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

Researchers release guidance to address pathology aspects in clinical trial protocols

COVID-19 lockdown linked with important changes in people's thought patterns

Study maps hotspots of low-value care use at individual health systems

China's declining birth rates and aging population may not hinder future prosperity

Researchers develop fast, low-energy artificial synapse for advanced AI systems

Risk factors associated with in-school transmission of SARS-CoV-2

COVID Moonshot receives key funding to accelerate drug discovery efforts

Confinement drastically reduced the transmission of COVID-19 variants in Spain during first wave

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

Most adults prefer monitoring blood pressure at home, research finds

New discovery greatly improves detection of HPV in the bloodstream

Pfizer-BioNTech’s COVID-19 vaccine appears effective against SARS-CoV-2 mu variant

Solar exposure guidelines for optimal vitamin D synthesis may need to be revised, study suggests

Voltammetry and machine learning for real-time neurotransmitter detection

How real-time off-gas analysis improves fermentation process control

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

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