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Scientists link proteins to Alzheimer’s through cutting-edge genetic method

Researchers have developed MR-SPI, a novel method integrated with AlphaFold3, to identify causal protein biomarkers and predict their 3D structural changes in Alzheimer’s disease. This breakthrough offers insights into disease mechanisms and potential therapeutic targets.

5 Dec 2024

Frontotemporal dementia disrupts empathy for pain, study reveals

Study reveals diminished brain activity related to empathy for pain in individuals with behavioral variant frontotemporal dementia (bvFTD), using task-based fMRI. Findings show a stark reduction in neural responses tied to affective empathy, highlighting early bvFTD impacts on social cognition.

5 Dec 2024

Can AI fix the peer review bottleneck? Top journals weigh in

Study examines AI's role in peer review among top 100 medical journals, revealing that while most journals provide AI guidelines, a majority prohibit its use due to confidentiality and ethical concerns. The findings highlight varied policies and emphasize the need for clear, unified guidance for AI integration in peer review.

5 Dec 2024

Study sheds light on Kif23's role in embryonic brain development and microcephaly

A team of researchers from Tohoku University, the National Center of Neurology and Psychiatry, and National Yang Ming Chiao Tung University has uncovered a novel molecular mechanism through which Kif23 (a motor protein belonging to the kinesin family) plays a vital role in embryonic brain development.

5 Dec 2024

Long-COVID lingers in children

A 24-month study reveals that 7.2% of children consistently experience long-COVID symptoms, with tiredness, sleep issues, and headaches most commonly reported, highlighting the need for targeted interventions.

5 Dec 2024

Dupilumab improves symptoms of atopic dermatitis in children with co-existing conditions

Research at National Jewish Health and other institutions has shown that the biologic dupilumab improves signs and symptoms of moderate-to-severe atopic dermatitis (eczema) in young children whether or not they have another inflammatory condition, such as asthma, allergic rhinitis or food allergies.

5 Dec 2024

New framework enhances genetic prediction of drug response and side effects

A UCLA study has outlined a new framework that researchers say would improve predictive power of genetics to determine how well a patient would respond to commonly prescribed medications as well as the severity of any side effects.

5 Dec 2024

Does air pollution worsen Long COVID? Researchers weigh in

Exposure to air pollutants, particularly particulate matter, may increase Long COVID risk by worsening initial infection severity, but noise, light, and green spaces show no significant impact, a Catalonian study reveals.

5 Dec 2024

PAGER technology unlocks new potential for controlling cellular activity

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists is to control that process, making cells respond how they want to what they want.

5 Dec 2024

Study uncovers dangerous side effects of AZD7648 in gene editing

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

Researchers develop diabetes prediction system using clinical and genetic data

A research team led by professor Nan-Hee Kim from Korea University's College of Medicine (Nan-Hee Kim and So-Young Park of Department of Endocrinology and Metabolism; Min-Hee Kim and Jae-Young Kim of Health Science Research Center) recently developed a diabetes prediction system using clinical and genetic data. The system was registered for the domestic patent.

5 Dec 2024

Homeownership linked to longer life for early 20th century Americans

A new study by an Oxford University researcher finds that owning a home in early adult life adds approximately four months to the lives of male Americans born in the early twentieth century.

5 Dec 2024

Redlining's legacy associated with shortened lifespan and health risks

Redlining - a mid-20th-century federal government practice of denying home loans in African American and other minority neighborhoods - has long been associated with poor health outcomes, including disparate overall mortality rates among racial and ethnic groups.

5 Dec 2024

Study identifies hidden chemical risks in household products

Southwest Research Institute (SwRI) collaborated with the Environmental Protection Agency (EPA) to characterize the chemical makeup of 81 common household items. Researchers also evaluated the potential risk to users.

5 Dec 2024

Concerns grow over accuracy and safety of direct-to-consumer health tests

Better information and regulation are essential to protect consumers from potential harms of tests advertised directly to consumers, argue experts in The BMJ today.

5 Dec 2024

Discovery of leptin-responsive neurons offers new hope for obesity treatment

Obesity affects a staggering 40 percent of adults and 20 percent of children in the United States. While some new popular therapies are helping to tackle the epidemic of obesity, there is still so much that researchers do not understand about the brain-body connection that regulates appetite.

5 Dec 2024

Study identifies key immune cells that could protect the brain after cardiac arrest

Despite improvements in CPR and rates of getting patients to the hospital, only about 10 percent of people ultimately survive after out-of-hospital cardiac arrest (OHCA), translating to about 300,000 deaths per year in the United States.

5 Dec 2024

Aging of lung stem cells drives iron deficiency and reduces capacity for tumor formation

Aging induces iron deficiency, reducing stem cell function and tumor growth while enhancing ferroptosis resistance, revealing new cancer prevention strategies.

5 Dec 2024

AI tool for heart failure screening demonstrates long-term cost savings

Earlier research showed that primary care clinicians using AI-ECG tools identified more unknown cases of a weak heart pump, also called low ejection fraction, than without AI. New study findings published in Mayo Clinic Proceedings: Digital Health suggest that this type of screening is also cost-effective in the long term, especially in outpatient settings.

5 Dec 2024

Psilocybin therapy reduces depression in clinicians after pandemic frontline work

This study demonstrates psilocybin's effectiveness in reducing depression symptoms in healthcare workers, offering hope for pandemic-related mental health care.

5 Dec 2024