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Polβ enzyme found to protect developing brain from harmful DNA mutations

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations.

18 Aug 2025

RNA quality control protein PELOTA found to slow aging and extend lifespan

As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases.

18 Aug 2025

Inactivation of stress pathway allows ER+ breast cancer cells to evade treatment

A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment.

18 Aug 2025

Endoplasmic reticulum controls cell movement to repair tissue gaps

The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals.

18 Aug 2025

New molecule shows promise in treating acetaminophen-induced liver injury

Acetaminophen is one of the most common painkillers and is found in hundreds of different medications. While safe at recommended doses, acetaminophen overdose is the leading cause of acute liver injury in the U.S.

18 Aug 2025

New nanoparticle system uses ultrasound to precisely deliver drugs

The trouble with many drugs is that they go where they shouldn't, producing unwanted side effects. Psychiatric drugs might cause dissociation, painkillers can induce nausea and chemotherapy often damages healthy cells.

18 Aug 2025

Fasting does not have the same effect on all body types, study suggests

While fasting has become a popular trend, particularly for people who hope to lose weight, new UBC Okanagan research suggests fasting does not have the same effect on all body types.

18 Aug 2025

Advancing cancer treatment with targeted microrobotic swarms

Cancer remains one of the most challenging diseases to treat, as conventional therapies like chemotherapy and radiotherapy are often hindered by poor specificity, systemic toxicity, and damage to healthy tissues.

18 Aug 2025

Highly sensitive individuals more prone to mental health challenges

The meta-analysis of 33 studies, the first of its kind, looked at the relationship between sensitivity and common mental health problems such as depression and anxiety.

18 Aug 2025

Targeting mitochondrial biogenesis to improve outcomes in acute kidney injury

Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease.

18 Aug 2025

Youth mental health crisis leads to prolonged emergency room stays

America's youth mental health crisis has escalated to the point that thousands of children primarily suffering from suicide-related behaviors and depression are stuck in hospital emergency rooms for three days or more, according to new research from Oregon Health & Science University.

18 Aug 2025

Exploring the complex origins of endothelial cells in tumor angiogenesis

This newly published review article offers a comprehensive examination of the complexities of tumor angiogenesis and the origins of endothelial cells (ECs) within tumors.

18 Aug 2025

Scientists urge shift in medicine to target the biology of aging

The most recent issue of Journal of the American Medical Association includes a landmark review highlighting innovative strategies to slow the biological aging process, an emerging approach with significant potential to prevent or delay multiple chronic diseases at once, one of the most pressing challenges in modern medicine today.

18 Aug 2025

Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

18 Aug 2025

Study shows promising anti-diabetic potential of coffee's functional components

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

18 Aug 2025

Laboratory reagent contamination threatens accuracy of infectious disease research

A new study warns that contamination from laboratory reagents could be misleading scientists worldwide in their hunt for emerging infectious diseases.

18 Aug 2025

Muscle stem cells show ability to transform and heal broken bones

When bones break and there is extreme tissue loss--such as after a car accident or a battlefield injury--current treatments don't often lead to effective healing.

18 Aug 2025

Irregular sleep patterns linked to higher mortality risk

Researchers in Korea followed over 9,600 adults for 15 years and found that both short and long sleep durations, especially when irregular, were linked to higher risk of death. The study highlights that 7–8 hours of regular sleep may be optimal for longevity.

18 Aug 2025

Using AI to enhance the design of nanoparticles for RNA therapies

Using artificial intelligence, MIT researchers have come up with a new way to design nanoparticles that can more efficiently deliver RNA vaccines and other types of RNA therapies.

18 Aug 2025

Lactylation drives tumor progression and immune evasion in triple negative breast cancer

Breast cancer maintains its position as the most prevalent malignancy in women worldwide, with triple-negative breast cancer (TNBC) representing the most treatment-resistant subtype due to limited therapeutic targets and frequent relapse.

18 Aug 2025