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Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

RENEW system utilizes machine learning for rare disease diagnosis

At Mayo Clinic, the mission to solve the unsolvable is at the heart of every rare disease case. Each diagnosis is a testament to perseverance, innovation and the relentless pursuit of answers.

25 Jun 2024

Brain processes immediate goals faster than distant ones

How does our brain distinguish between urgent and less urgent goals? Researchers at the University of Geneva (UNIGE) and the Icahn School of Medicine in New York have explored how our brain remembers and adjusts the goals we set ourselves on a daily basis.

25 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Teleneurology offers solution to neurologist shortage

One of the first studies to examine patient acceptability of teleneurology and determine factors influencing acceptability across neurological conditions, has found teleneurology was highly acceptable across the full range of patients with different neurological diagnoses, including headache, movement disorders and other neurological symptoms and diagnoses. The study also determined that the more medical complexity -- having additional diseases -- was associated with increased patient satisfaction with teleneurology.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

Global food collapse looms amid heat and water stress, warns new study

By 2050, global food production could decline by up to 14% due to heat and water stress, leading to 1.36 billion more people experiencing severe food insecurity, highlighting the urgent need for climate change mitigation.

25 Jun 2024

Personal choices drive young adults' alcohol abstinence with cannabis as a common substitute

Personal decisions, such as disinterest and avoiding drunkenness, are the primary reasons young adults abstain from alcohol, with financial concerns also playing a significant role, according to a recent study.

24 Jun 2024

Quality Improvement Program for Missouri saves millions and enhances elder care

A researcher at the University of Missouri has developed a program that improves the quality of care and reduces avoidable hospitalizations in nursing homes - saving Missouri nursing homes and Medicare millions of dollars and allowing Missouri nursing homes to invest more in retaining their most skilled staff members.

24 Jun 2024

Scientists discover link between birthweight and risk of health complications from childhood obesity

Scientists at the University of Copenhagen discover a link between birthweight and the risk of health complications from obesity during childhood.

24 Jun 2024

First child receives skull-mounted epilepsy device in UK clinical trial

Oran, who had been having severe epileptic seizures for eight years and often needed resuscitation, was the first child in the UK to have this device implanted at Great Ormond Street Hospital in October 2023, when he was 12 years old.

24 Jun 2024

Positive emotion skills improve health care workers' well-being

The COVID-19 pandemic exacerbated already rising rates of burnout among American health care workers.

24 Jun 2024

Mouse studies suggest gestational CBD exposure alters offspring behavior and brain function

Cannabidiol (CBD), one of the active ingredients in cannabis, is thought to be safe as it does not cause a "high".

24 Jun 2024

Innovative fingerprint technique detects TB antibiotics with high accuracy

A fingerprint may soon be all a doctor needs to check whether tuberculosis patients are taking their antibiotics – thanks to a new study led by the University of Surrey.

24 Jun 2024

Eating cheese during pregnancy linked to better neurodevelopmental outcomes in children

Researchers found that higher maternal intake of yogurt and cheese during pregnancy significantly reduces the risk of neurodevelopmental delays in children at age 3.

24 Jun 2024

UCL research reveals anxiety as a major risk factor for Parkinson's

The risk of developing Parkinson's is at least twice as high in people with anxiety compared to those without, finds a new study by UCL researchers.

24 Jun 2024

WEHI study reveals new methods in detecting necroptosis

Fully automated diagnostic techniques, including liquid handling robots, are poised to improve the lives of millions of people living with inflammatory diseases worldwide.

24 Jun 2024

Chronic loneliness linked to increased stroke risk in older adults

Chronic loneliness may significantly raise older adults' risk of stroke, according to a new study led by Harvard T.H. Chan School of Public Health.

24 Jun 2024

Enhancing adoptive T-cell therapy with nanowire innovation

Adoptive T-cell therapy has revolutionized medicine. A patient's T-cells - a type of white blood cell that is part of the body's immune system - are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells.

24 Jun 2024

Study reveals cannabis and tobacco users face higher COVID-19 hospitalization and adverse outcomes

Researchers found that cannabis and tobacco use significantly increase the risk of hospitalization and adverse outcomes in COVID-19 patients, even when controlling for other factors.

24 Jun 2024