Chronic kidney disease linked to a single gene mutation

New research in the US has found that a mutation in a single gene causes a form of chronic kidney disease.

The researchers studied a New Zealand family in which some members suffered from familial focal segmental glomerulosclerosis or FSGS, a type of kidney disease that can lead to complete kidney failure.

The scientists from Duke University Medical Center found a mutation in a gene called transient receptor potential cation channel 6 or TRPC6, in every family member who had FSGS.

This finding may well lead to more effective treatments for the disease, which is on the increase in the United States, particularly among African-Americans.

FSGS affects 20 percent of patients undergoing dialysis, a process where a patient's blood is pumped through a machine that filters out wastes and other products, a function the kidneys would normally do.

The report is published in Science Express and in the early online version of the journal Science.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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