Pregabalin decreases pain after knee replacement surgery

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The drug pregabalin, administered before and after knee replacement surgery, significantly decreased patient pain while increasing and expediting mobility after surgery, according to a new study.

Total knee replacement (TKR) is one of the most prevalent and painful orthopedic surgical procedures. With an increasing aging population, the number of knee replacements performed in the United States increased by 69 percent from 1997 to 2005, with an estimated 314,000 TKR procedures expected to be done each year in the United States by 2010. While extremely successful in ultimately ending or minimizing knee pain and disability, the procedure can result in postoperative knee stiffness, mechanical failure, and severe, chronic pain.

Asokumar Buvanendran, M.D., director of orthopedic anesthesia and associate professor of anesthesiology, Rush University Medical Center, Chicago, Illinois, conducted the study with 60 TKR patients in two groups. One group received 300 milligrams of pregabalin (an anti-convulsant) two hours before surgery and 150 milligrams twice a day for 14 days following surgery. The other patients were given placebos at the same intervals. Both groups received pain medication through an epidural catheter during surgery and after surgery through a patient-controlled device.

The study found a “significant decrease” between the pregabalin and placebo groups in pain medication consumption in the 32 hours following surgery at all time points. The pregabalin group also consistently reported pain levels between 2 and 4 (on a scale of 1 to 10, with “10” being most severe) following surgery.

In addition, the patients' knee range of motion (ROM) following surgery was higher in the pregabalin patients at hospital discharge: 84 degrees compared to 76 degrees among non-pregabalin patients. At 83 degrees a patient can climb stairs. According to Dr. Buvanendran, it typically takes a patient a full week to reach that level.

Administration of pregabalin “decreased postoperative analgesic requirements while improving function,” Dr. Buvanendran said, noting that the ROM improvements are “especially important.”

“When you can walk up and down stairs, it makes a huge difference in patient quality of life,” he said. In addition, the improved range of motion allows patients to complete necessary post-surgical rehabilitation more quickly.

Founded in 1905, the American Society of Anesthesiologists is an educational, research and scientific association with 41,000 members organized to raise and maintain the standards of the medical practice of anesthesiology and improve the care of the patient. Visit our Web site at


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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