Enhanced skin cancer risk linked to defects in cellular aging controls

Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied.

A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.

Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin cell regeneration, and that limiting the activity of a tumor suppressor signaling protein, p53, restores cell regeneration and reduces hyperpigmentation. Surprisingly, limiting p53 activity also advances the progression of skin cancers.

This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Breakthrough blood test improves early diagnosis of pancreatic cancer