Feb 3 2010
Personalizing medicine: Experts examine use of nanoparticles for targeting disease
SNM's Nanomedicine and Molecular Imaging Summit wrapped up today in Albuquerque, N.M., with in-depth discussion-and a high sense of energy looking ahead.
Nanotechnology is a quickly growing, but still-evolving field with nearly limitless possibilities for applying technology in highly targeted ways. For the medical community, nanotechnology involves using nanoparticles to target disease-and treat many common and devastating diseases before they spread. Concomitantly, molecular imaging can be used to assess the health and environmental impacts of nanomaterials.
"Nanotechnology has the potential to revolutionize the way in which many common diseases are diagnosed and treated," said Peter S. Conti, M.D., Ph.D., professor of radiology at USC's Keck School of Medicine. "There are issues that need to be resolved, however, in order to make this technology clinically relevant. SNM's Molecular Imaging Center of Excellence summits serve a key role in the community by bringing together the appropriate experts to explore all facets of an issue."
Nanotechnology: Providing a Regulatory Framework in the U.S.
As part of the summit, advisors from the U.S. Food and Drug Administration (FDA) provided a regulatory framework for developing nanotechnology and targeted radiopharmaceuticals.
"FDA is pleased to work with SNM, physicians and other members of the molecular imaging community on the critical field of nanotechnology, which is evolving at a rapid pace as new technologies make these developments possible," said Wendy Sanhai, Ph.D., M.B.A., senior scientific advisor in the Office of the Commissioner at FDA.
Working in concert with SNM and other stakeholders, FDA is seeking to educate imaging physicians, researchers and other stakeholders about the regulatory requirements for novel techniques and regulatory pathways. Dr. Sanhai's discussion, presented at a session on regulatory considerations, focused on ways to advance the science of nanotechnology.
Lori Sheremeta, LL.M., a lawyer and research officer at the National Research Council's National Institute for Nanotechnology at the University of Alberta, Edmonton, Canada, and special advisor to Alberta Innovates-Technology Futures, discussed regulatory and public policy challenges regarding nanomaterials in the face of scientific uncertainty.
"One of the most promising-but also challenging-aspects of nanomedicine is that we do not know exactly what the next scientific discovery or breakthrough will bring," said Sheremata. "However, the promise of nanomedicine and molecular imaging is the ability to revolutionize the field and change the way in which many common diseases are diagnosed and treated."
Nanotechnology, Biodistribution and Drug Development
At another session, John V. Frangioni, M.D., Ph.D., associate professor of medicine and radiology, and Hak Soo Choi, Ph.D., instructor in medicine at Harvard Medical School's Beth Israel Deaconess Medical Center, spoke about design considerations for nanoparticles that interact with the body.
"Using quantum dots as a model system, we have systematically defined the physicochemical parameters that mediate uptake of nanoparticles by the lung, their biodistribution to tissues, organs and tumors and their clearance from the body," said Frangioni. "This represents the complete cycle of nanoparticle trafficking from the environment, through the body and back to the environment."
Dr. Frangioni and Dr. Choi's presentations reviewed recent developments in the field and discussed how this new understanding of nanoparticles might guide future studies in air pollution, drug delivery and carcinogenesis.
Using Nanotechnology to Diagnose and Treat Disease
King Li, M.D, M.B.A., chair of the department of radiology at the Methodist Hospital Research Institute, spoke at a third session that gave participants the opportunity to discuss in-depth how nanotechnology can be used to diagnose and treat disease.
"Much of the current molecular biology research focuses on finding new molecular targets and pathways that are responsible for various disease processes," said Li. "It is hoped that once these molecular targets have been identified, the right combination of physical, biologic and chemical agents can potentially give us unprecedented control in our treatment regimens."
As the field of nanotechnology continues to develop, medical imaging will play a key role in better understanding how nanoparticles can be used to precisely target and treat the biological underpinnings of cancer, neurological conditions and cardiovascular disease.
Tremendous Discoveries Ahead
As the two-day summit wrapped up, Julie Sutcliffe, Ph.D., program chair and associate professor at the University of California, Davis, said, "New applications for nanotechnology in medicine are being discovered at a tremendous pace." She added, "Noninvasive imaging technologies have the potential to accelerate this process. This year's summit made critical strides toward examining some of the key issues related to the rapid growth and evolving science of nanomedicine."
The summit explored ways in which molecular imaging and therapy currently use nanotechnology, as well as how these methods can facilitate advancements in the understanding and proper management of nanomaterials both for the environment and human health.