Affymetrix anticipates $85 million total revenue for fourth quarter 2010

The Company also announced that it has repurchased an additional $53 million face value of 3.5% convertible notes. The Company repurchased more than $150 million of 3.5% convertible notes in 2010 and now has about $95 million in outstanding convertible debt. The Company expects to have a year-end net cash balance of approximately $140 million.

"We made significant progress in 2010 and we expect to report positive operating income and net income for both the fourth quarter and the second half of 2010," said Kevin M. King, president and chief executive officer. "These results reflect our disciplined focus on operations which has significantly lowered our break-even point. We exit 2010 in a strong financial position and we are committed to the continued improvement of our business in 2011 and beyond."

Affymetrix will webcast its presentation at the 29^th Annual JP Morgan Healthcare Conference on Thursday, January 13, 2011 at 7:30 a.m. PT. A live webcast will be available at http://www.affymetrix.com under the "Investors" link. The archived webcast will be available for 30 days.

Affymetrix' management team will host a conference call on February 2, 2011 at 2:00 p.m. PT to review its operating results for the fourth quarter and fiscal year 2010. A live webcast can be accessed by visiting the Investor Relations section of the Company's website at www.affymetrix.com. In addition, investors and other interested parties can listen by dialing domestic: (877) 407-8291, international: (201) 689-8345.