Kowa announces data of LIVALO vs. Crestor on pharmacodynamics of warfarin

Kowa Pharmaceuticals America, Inc. today announced data assessing the effect of LIVALO® (pitavastatin) compared with Crestor® (rosuvastatin) on steady-state pharmacodynamics (PD) of warfarin by measuring international normalized ratio (INR) in healthy adult subjects.  The study, published in Current Medical Research & Opinion, showed INR during stable warfarin treatment did not change significantly when LIVALO was added to the regimen, while a significant increase was observed when Crestor was added to warfarin. INR is a laboratory test that measures the time it takes for blood to clot and compares it to an average. Warfarin is a widely used anticoagulant that inhibits vitamin K-dependent clotting factors to prevent blood clot formation.

It is not uncommon for patients on chronic warfarin therapy to have high cholesterol that requires lipid modifying agents, particularly statins. The concomitant use of statins and warfarin has been studied, and a large database outcomes study reported that the initiation of certain statins was associated with an increased risk of hospitalization for gastrointestinal bleeding. LIVALO and Crestor have not been studied in this context. Given there may be potential differences among statins and their effect on warfarin, the purpose of the study was to assess the effect of LIVALO compared with Crestor on steady-state INR when coadministered with warfarin.

Results showed that, in healthy subjects taking LIVALO 4 mg, mean INR changed from 1.73+/-0.18.

"These data are important as this is the first study to investigate differences in steady-state pharmacodynamic response and effect on anticoagulation between two statins when each are independently added to warfarin," said Craig Sponseller, MD, Vice President of Medical Affairs, Kowa Pharmaceuticals America, Inc.  "Physicians now have additional information to reference with this pharmacodynamic data when considering statin options for patients with high cholesterol who are on chronic warfarin treatment."

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Research reveals only a few brain regions remain untouched by transition to motherhood