Proton pump inhibitors linked to increased risk of heart attack

NewsGuard 100/100 Score

People who use proton pump inhibitors (PPIs) are up to 21% more likely to experience a heart attack than people who do not use the antacids, according to researchers from Houston Methodist and Stanford University, California.

Our results demonstrate that PPIs appear to be associated with elevated risk of heart attack in the general population," says Nigam Shah, lead author of the paper and assistant professor of biomedical informatics at Stanford.

The findings come from a study of 16 million clinical documents representing 2.9 million people. Shah and team collected data about 1.8 million Stanford hospital and clinical patients and 1.1 million patients from a Web-based electronic medical records company. The data were scanned for patients who had been prescribed PPIs or other antacids such as H2 blockers to see whether any major cardiovascular events were mentioned in their records.

Heart

As reported in PLOS ONE, the use of PPIs was associated with a 16 to 21% increased risk of myocardial infarction.

"Our report raises concerns that these drugs – which are available over the counter and are among the most commonly prescribed drugs in the world – may not be as safe as we previously assumed," says principal investigator Nicholas Leeper.

Had they been in place, pharmacovigilance algorithms could have flagged this risk as early as the year 2000,” the researchers comment.

The team also found that the use of H2 blockers was not associated with any increased risk of a cardiovascular event.

Estimates from the Food and Drug Administration (FDA) show that about one in 14 Americans have been prescribed PPIs and in 2009, PPIs were the third most commonly used drug in the U.S. The drug is prescribed to treat various disorders such as gastro-esophageal reflux disease (GERD), Helicobacter pylori infection and Barrett’s esophagus. Examples of brand names for PPIs include PrevAcid, Prilosec and Nexium and examples of H2 blockers are Zantac and Tagamet.

The researchers say they plan to conduct a large, randomized trial to confirm whether PPIs are harmful in a broader patient population.

Sally Robertson

Written by

Sally Robertson

Sally first developed an interest in medical communications when she took on the role of Journal Development Editor for BioMed Central (BMC), after having graduated with a degree in biomedical science from Greenwich University.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Robertson, Sally. (2019, June 19). Proton pump inhibitors linked to increased risk of heart attack. News-Medical. Retrieved on May 23, 2024 from https://www.news-medical.net/news/20150611/Proton-pump-inhibitors-linked-to-increased-risk-of-heart-attack.aspx.

  • MLA

    Robertson, Sally. "Proton pump inhibitors linked to increased risk of heart attack". News-Medical. 23 May 2024. <https://www.news-medical.net/news/20150611/Proton-pump-inhibitors-linked-to-increased-risk-of-heart-attack.aspx>.

  • Chicago

    Robertson, Sally. "Proton pump inhibitors linked to increased risk of heart attack". News-Medical. https://www.news-medical.net/news/20150611/Proton-pump-inhibitors-linked-to-increased-risk-of-heart-attack.aspx. (accessed May 23, 2024).

  • Harvard

    Robertson, Sally. 2019. Proton pump inhibitors linked to increased risk of heart attack. News-Medical, viewed 23 May 2024, https://www.news-medical.net/news/20150611/Proton-pump-inhibitors-linked-to-increased-risk-of-heart-attack.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Yogic practices enhance heart health and functional capacity in heart failure patients